Conserved Protein Domain Family
COG4

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pfam08318: COG4 
COG4 transport protein
This region is found in yeast oligomeric golgi complex component 4 which is involved in ER to Golgi an intra Golgi transport.
Statistics
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PSSM-Id: 462425
Aligned: 111 rows
Threshold Bit Score: 194.346
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS99807     225 LEEARASLCGLFLREFERAAQDGDDARVTRFFKLFPLIGRTDVGLDVYGRYVCQGVAESARNVFRGEtpqpaavpaaasR 304 
EFJ37060     154 llESKRKLEEVIKKRFYAAVDARDHAGVVRFASLFAPLGLHEEGIKAYVSYLRRSVDHRARDGFAAVke----------t 223 
XP_004243228 172 llASKKQLEGIVRRKLAEAVDQRDHSTVLRFIRLYPPLALEEEGLQVYVMYLKKVIAMRSRLEYEQLvemms--dqqgsS 249 
Q8L838       176 LHASKEQLEGIAKKKLLAAIDQRDHPTILRFVRLYSPLGMETEGLQLYVGYLKKVIALRGRMEYENVvelm-----eqgL 250  thale cress
KRH68961     184 llAAKKQLEGIVRKKLSAAVDQRDHPAILRFIRLFTPLGVEEEGLQVYVGYLKKVIAMRSRMEFEQLvem--------md 255 
ERM93568     179 ilESKRQLESIVRKKLSAAVDQQTHGEILRFVRIFPMLGLRAEGLQIYVSYLRKVISMRTRMEFDTVkefi----dqsrP 254 
XP_002468432 190 llDIKRRLEGLARRRLAAVIDAQDHPAVLRLVRLFPLLGLADEGLQVYVAYLKKVVALRARADFEHLaelts---atqpT 266 
EFC48634     118 fKKSEKKIKEIVSSKMKEALRDENETQIKRFSKLFSPLCMNEDGLSLY----VDFLSDKCRKELESLdeverltyirkqQ 193 
Q4DDH2       241 iASARESAREKLLEKFRVASRSNDKLTIMQATRLLTQLGFSEEGCSLYCTWLCEHTIAALKKMVDRElrkm-----ddpT 315  Trypanosoma cruzi
CBI38713     144 lmASKKQLEGIVRKRLAAAVDQRDHPTILRFVRLFSPLNLEEEGLQMYVNYLKKVIGMRSRLEYEHLvelme---qssgN 220  wine grape
ERS99807     305 HDGFFFANALAKLFTHISQIVEGHGALVERHYGGGQMIK-VISRLQKEADVQGGIVVDAWSDERGVDRKLTDVKSYPFSf 383 
EFJ37060     224 pDQADFVAALNNIFKDIAEAIEENEELLKSLNGEDGLVY-AIRELQEECDSRGSAIVKKYMEFRGLAKLEKEIIAQTN-- 300 
XP_004243228 250 QNQLNFVSCLTNLFKDIVLAIEENDETLRSLCGEDGIVY-AICELQEECDSRGSTIIKKYMEYRKLAKVTSEINSYKS-- 326 
Q8L838       251 -GQVNFVGCLTNLFKDIVMAIEENDEILRGLCGEDGVAY-AICELQEECDLRGSLILKKYMDFRKLAILASDINNSPNl- 327  thale cress
KRH68961     256 qQNVNFVGCLTNLFKDIVLAIEENSEILSGLCGEDGIVY-AICELQEECDSRGSVILNKYMEYRQLAKLSSEINAHNTn- 333 
ERM93568     255 PSEINFVNCLTSLFKDIVLAVEENDAVLRELCMEDGVVY-AICELQEECDLWGTTIMKKYMEFRKLGKITADINSYSK-- 331 
XP_002468432 267 SERLDFVGCLTRLFKDIVLAVEENDAVLRELRGDDGVAY-AIIELQEECDSRGTQILRRYADYRKLARLASDINSYTK-- 343 
EFC48634     194 QQYVSFIDIITQILDIIVSYIEDCEDFVTSNFGGEKCTIyLINSLQHVCDKMVKKVLDVYEKKRELNDILTAVSKKPN-- 271 
Q4DDH2       316 EAGMSHLGLVSTVLDAVVAAFENEEEFIRETFGDAGLLK-LLTELHCKSTSQCVPVLKDFLKKRQE--VLSSVTSAGGIn 392  Trypanosoma cruzi
CBI38713     221 QSNVNFVGCLTNLFKDIVLAVQENSEILRSLCGEDGIVY-AICELQEECDSRGSSILKKYLDYRKLARLTSEINSYKN-- 297  wine grape
ERS99807     384 lvqsfgmkgaggsssnsnaggggggdgaSRVNSPALGVD---SPRRSEDEgGVNMREIDGLLNEIAIMLSRWSLYSRFLA 460 
EFJ37060     301 -------------------------------AEKDIVAQsklLMSAGGAAeGPDLRSIEMFLEEILLLIQTSEDYTQYMI 349 
XP_004243228 327 -------------------------------------------DLLSVGIeGPDPRDIEVYLEEILSLTQLGEDYTGYMI 363 
Q8L838       328 ------------------------------------------NILPGGASeGPDPREVELYVEEILSLMQLGEDYTEFMV 365  thale cress
KRH68961     334 ------------------------------------------LLAVGGGPeGPDPREVELYLEEILNLMQLGEDYTEFMI 371 
ERM93568     332 ------------------------------------------NLLSVGVLeGPDPREIEMYLEEILALTQLGEDYTEFMV 369 
XP_002468432 344 ----------------------------------NLLSAmgsMASAAGGNeGPDPREIELYLEEILALTQLGEDYTEFMV 389 
EFC48634     272 ------------------------------------------TLPIKKDLnTNDPRVLDLILEEIAEISSNIEVYKQFIA 309 
Q4DDH2       393 tnsssss-------------sgnargqfPAGSVEAAAGSpvfPTTSSAVAaTVDPRRTDQILEEMSHLVSCCHLYWTFAQ 459  Trypanosoma cruzi
CBI38713     298 -------------------------------------------RLSVGAAeGPDPREIELYLEEILSLMQLGEDYTEFMV 334  wine grape
ERS99807     461 NKCrddeaeaaaqaeadakdtkkeksgkdgqdgqdskdsSTErat-----aaTPDERPLVIPSVLAQSN---LQRKVaAR 532 
EFJ37060     350 GRVrea--------------------------------------------gsSGAQLSPRSTTSFKVGS---FYRAV-QE 381 
XP_004243228 364 SKIrgl--------------------------------------------ssVDPELGPRATKAFRSGN---FSKVV-QD 395 
Q8L838       366 SKIksl--------------------------------------------tsVDPELLPTATKAFRNKS---FSKAI-QD 397  thale cress
KRH68961     372 SKIkal--------------------------------------------tsVDPELLPRATKAFRSGS---FSKVA-QD 403 
ERM93568     370 SKIggm--------------------------------------------aaLDPQLAPRATKAFRSGS---FSIMA-QE 401 
XP_002468432 390 NKIrgl--------------------------------------------rdVKPELGPRAMKAFRNGN---FNKME-QD 421 
EFC48634     310 GKCi-----------------------------------------------nIKTDGKNEMYTLTKEPI---IYRRI-QE 338 
Q4DDH2       460 SKQ------------------------------------QEYmhgveatgkqHEQQEVVVSVDSLWSSRdnpLMNTV-QE 502  Trypanosoma cruzi
CBI38713     335 STIkgl--------------------------------------------ssVDPELGPRATKAFRNGN---FSRSI-QD 366  wine grape
ERS99807     533 LITPYSLMSTFFFRRSVEKAF--QLEETPGdlsl---------------------------------------------- 564 
EFJ37060     382 LTSHYRLLEEYFMAENVRKAI--KLDEFP--------------------------------------------------- 408 
XP_004243228 396 ITGYYVILEGYFMVENVRKAI--KIDELV--------------------------------------------------- 422 
Q8L838       398 VTRYYVILEGFFMVENVRKAI--RIDEHV--------------------------------------------------- 424  thale cress
KRH68961     404 LTGFYVILEGFFMVENVRKAI--KIDEQV--------------------------------------------------- 430 
ERM93568     402 LSGYYVILEEFFMVENVRKAI--RIDEHV--------------------------------------------------- 428 
XP_002468432 422 LTGFYVIFEEFFMVENVRKAI--RIDEPI--------------------------------------------------- 448 
EFC48634     339 LMSFYIPIDMSFMKQSFFKAI--QLESDED-------------------------------------------------- 366 
Q4DDH2       503 ILGVFVPLQTLYFEAAFEQALrlQMDALHAaarealmsgtegggdlsarkrtgvivhssshhhhhhqsskknetysspsa 582  Trypanosoma cruzi
CBI38713     367 ITGYYVILEGFFMVENVRKAI--NIDEHV--------------------------------------------------- 393  wine grape
ERS99807     565 ------------------nmadAl------dNNPPYIISAVDDVMYIVNAVIQKCMSTLQRDVVVGVIPPVGRVLGSDFI 620 
EFJ37060     409 --------------------------------ANSLTTSVVDDVFYVLQSCTRRAVSTSNVHLTLSIVTCAANLLGNEYK 456 
XP_004243228 423 --------------------------------FDSLTTSMVDDVFYVLQSCCRRSISTSNINSVIAVLSSAVSLLGGEFN 470 
Q8L838       425 --------------------------------PDSLTTSMVDDVFYVLQSCLRRAISTSNISSVIAVLSYAGSLLGNDYH 472  thale cress
KRH68961     431 --------------------------------PDSLTTSMVDDVFYVLQSCLRRAISTSNISSVVAVLSGASSLLGNEYH 478 
ERM93568     429 --------------------------------PDSLTTSMVDDVFYVLQSCCRRAISTSKVNSVLAVLSGAVNLLSNEYQ 476 
XP_002468432 449 --------------------------------PDGLTTSMVDDVFFVLQSCCRRAASTASINSVLAVLGGATSLLSNEYQ 496 
EFC48634     367 ----------------------E--------DESSKYSSIINDVFFILQKSLSRAMDSQNVSVVCAIVNHINGILATDYF 416 
Q4DDH2       583 kktanfmtglaalytstaaasgGedeempdaAMDQVSITLPDDVFFFLRIALHRAVNTKSTQIISAVFIACIELVQSKLL 662  Trypanosoma cruzi
CBI38713     394 --------------------------------PDSLTTSMVDDVFYVLQSCLRRAISTSNINSVLALLSGSISLLGNEYQ 441  wine grape
ERS99807     621 GMIQRKM 627 
EFJ37060     457 DALQRKM 463 
XP_004243228 471 EALQQKV 477 
Q8L838       473 EALQQKI 479  thale cress
KRH68961     479 EALQHKT 485 
ERM93568     477 EALQRKM 483 
XP_002468432 497 EALQWRM 503 
EFC48634     417 EFVKKDv 423 
Q4DDH2       663 pvlqlqt 669  Trypanosoma cruzi
CBI38713     442 EALQQKM 448  wine grape
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