Conserved Protein Domain Family
FH_FOXL1
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cd20027: FH_FOXL1 
Forkhead (FH) domain found in Forkhead box protein L1 (FOXL1) and similar proteins
FOXL1, also called Forkhead-related protein FKHL11 or Forkhead-related transcription factor 7 (FREAC-7), acts as a transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. It may play a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410801
Aligned: 15 rows
Threshold Bit Score: 194.645
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                 ##  #                  ## ##  #      #         ### #   
Q12952        47 PQKPPYSYIALIAMAIQDAPEqRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLSLNDCFVKVPREKGRPGKGSYWTLD 126 human
AMY99566      59 PQKPPYSYIALIAMAIKNSPErKLTLNGIYQFIMERFPYYHDNKQGWQNSIRHNLSLNDCFMKVAREKGKPGKGNYWTLD 138 Owenia fusiformis
BAQ19220      43 PQKPPYSYIALIAMAVKASPDrKVTLNGIYQFIMERFPYYHDNKQGWQNSIRHNLSLNDCFVKVPREKGKPGKGNYWTLD 122 owl limpet
NP_957278     50 PQKPPYSYIALIAMAIKNAPDkRATLSGIYQFIMDRFPYYHDNKQGWQNSIRHNLSLNDCFIKVPREKGRPGKGSYWTLD 129 zebrafish
XP_007887429  54 PQKPPYSYIALIAMAIKSAHEqKVTLNGIYQYIMERFPFYHDNKQGWQNSIRHNLSLNDCFVKVSREKGKPGKGSYWTLD 133 elephant shark
KYO37919       7 PQKPPYSYIALIAMAIKEAPDqKVTLNGIYQFIMERFPFYHDNKQGWQNSIRHNLSLNDCFIKVPREKSRPGKGSYWTLD 86  American alligator
NP_001161544  53 PQKPPYSYIALIAMAIRSAPDqKTTLNGIYQFIMERFPYYHDNKQGWQNSIRHNLSLNDCFVKVPREKGKPGKGNYWSLA 132 Saccoglossus ko...
XP_019629840 186 HQKPPYSYIALIAMAIRSSPDqKITLNGIYQWIMDRFPYYHDNKQGWQNSIRHNLSLNDCFVKVPREKGKPGKGNYWTLN 265 Belcher's lancelet
XP_013775960  64 PQKPPYSYIALIAMAIRSAPEqKISLNDIYRFIMDRFPYYHDNKQGWQNSIRHNLSLNECFVKIPREKGKPGKGNYWTLD 143 Atlantic horses...
ABB89488      43 PQKPPYSYIALIAMAIRNSSDkKVTLNGIYQFIMDRFPYYHDNKQGWQNSIRHNLSLNDCFVKVAREKGKPGKGNYWTLA 122 purple sea urchin

Feature 1                          
Q12952       127 PrCLDMFENGNYRRRKRK 144 human
AMY99566     139 PnCDEMFDNGNYRRRKRR 156 Owenia fusiformis
BAQ19220     123 PnCEEMFENGNYRRRKRR 140 owl limpet
NP_957278    130 TkCLDMFENGNYRRRKRK 147 zebrafish
XP_007887429 134 PrCVDMFENGNYRRRKRR 151 elephant shark
KYO37919      87 PkCLDMFENGNYRRRKRK 104 American alligator
NP_001161544 133 PdCEEMFENGNFRRRKRR 150 Saccoglossus kowalevskii
XP_019629840 266 QdCEEMFENGNYRRRKRK 283 Belcher's lancelet
XP_013775960 144 PaYEEMFENGNFRRRKRR 161 Atlantic horseshoe crab
ABB89488     123 AdCEDMFENGNFRRRKRR 140 purple sea urchin

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