Conserved Protein Domain Family
RXYLT1-like
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cd21099: RXYLT1-like 
ribitol-5-phosphate xylosyltransferase 1, and related proteins
Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1, also known as transmembrane protein 5, TMEM5) is a transmembrane protein which acts as a UDP-d-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase in the biosynthetic pathway of O-mannosyl glycan. RXYLT1 catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan. O-mannosyl glycan is present in a number of glycoproteins, including alpha-dystroglycan. The TMEM5 gene has been associated with alpha-dystroglycanopathies, a diverse group of neuromuscular disorders caused by aberrant O-mannosylation of alpha-dystroglycan.
Links
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Statistics
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PSSM-Id: 467845
Aligned: 17 rows
Threshold Bit Score: 477.156
Created: 23-Dec-2019
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q08CD5        96 VQIWGKAAIGLYLWEHILeGSLNPSDks-sqWREGEIqsGKIHFSFYTGPAVVQGHVPPDtdSVVLVLNGREQQKISYSV 174 Danio rerio
XP_029641869  96 VEIWGKAAIGLYLWEHILnGHLERKLgg--mWSYGMKkiNNIRFKFRTGPGVIPSKVPKSteNVILVLNGREPSKIDFAK 173 Octopus vulgaris
ELU15959      19 VEVWGKAAIGLYLWQHILeGSLEERLgg--vWNFGELqhRDLKLRFRTGPGVVPAKVPHDvqHLVLVLNGREPAKIDFAV 96 
XP_013401373 127 IELWGKAAIGLYLWEHIMnSTLEDRLgg--vWQYGSKriQNLIFRFRTGPGVVPHKAPKDveNLVLVLNGREQSKIDFAK 204 Lingula anatina
XP_011662351  74 IEIWSKVGLGSYTWEHILnGKLESRLdg--iWYYGELqvHNFEFRMRDGDGVQPDKVPQDveNVFLILNGRAPDKVQYTR 151
XP_029842214  73 VEIWSKAAIGLYLWEHILnGRLEPKGgg--aWSYGFRkiADIKFKFRTGPGIVPSTVPQDatHVVLVLNGRAPEKVAAAR 150
XP_002108942  26 VEIWGKAAIGEYLWRHVFnETIINKIdergaVSVGTDiiNDVGFKFLSGPGIIQQNSGKDseNVILILNGRSSDKIKFAK 105
XP_001744677  18 GQVWSKAAVGDYFIEHIMgTKPEPRLsg--vWYFARTfcGPLRFTYRAGHGVAPHKVPNDprHVVLILNGHDDEHAATAR 95 
XP_012565809  52 VYVWGKAAISEYFWTHIIeGVVQRSNky--iWDEGVIqiNSVKLVYFTGPALLPETAPKDikDLVVILNGREEKKINASL 129
XP_004347843 116 VEIWSKAAIGDYFWTDIFrGSTKYIAdg--hYSHGEQivSDVRLRFRAGSGLKPANAPPTtrHVVMILNAHNPEKMVTAK 193

Q08CD5       175 QWLQhvqsliqarTISRVAVVLLGNEQC-NNNWIsPYLKrnggfVDLLFLVYDSPWVNdk-dIFQWPLGVATYRHFPvvt 252 Danio rerio
XP_029641869 174 LWLDflp---tltNLKNVAVILLGNEQC-NNEWIkSYMQlrggpVKFVFLVYDSPDIDdq-nFYQWPLGVATYRDFPkvd 248 Octopus vulgaris
ELU15959      97 SWLEfis---elkHLRHVVLVLLGSERC-ENQWAwRYLRgdggpVDMVYLVYDSVSVDgn-mIHQWPLGVATYRSFPlve 171
XP_013401373 205 IWLDsls---tfeKLKNVAVILLGNEQC-DNEWIkQYLVqngglVKLVFLVYDSPDVDnv-nFYQWPLGVATYRGFPkfr 279 Lingula anatina
XP_011662351 152 YWLDhlg---sypHLKRVVLMLIGNEQC-QNDWVlPYMRsrggpVDMLFVVYDTLIVNgd-dIMQWPLGVATYRGFPlie 226
XP_029842214 151 TWLDalp---gfrKLRGVAVVLLGSEACsGNSWLlPYLRsrggpVAAAFIVYDTALVDda-eVFQWPLGVATYRGFPkat 226
XP_002108942 106 TWLEhlp---slkKLRNVALVMLGNERC-DNKWIdPYVNdnrykVRIVHLVYDDPRIDqq-kFYQWPLGVATYRGFPlvs 180
XP_001744677  96 PWLDllp---slpQLRSVGLIVLGYEDC-SNTWLaPYLRdpcykISFTFMVYGGQWPGak-dMMQWPLGVATYRGFPael 170
XP_012565809 130 KWLNsllnkklfpLLQNLGIIMLGNEQC-NNSWLiDLCKqa-lkIKFVFIVYDINLSYppyfYYQWPLGVATYRKFPlik 207
XP_004347843 194 ALLDela---glrHVRNVGLVVLGSELC-DNQWLePYLPf----VKFVFMVYHDASMIdndkIFEWPLGIATYRKFErrk 265

Q08CD5       253 lss--------qmvkkdRPYLCNFLGTIYKNSSreslmnll--------------------------------------- 285 Danio rerio
XP_029641869 249 sah--------lpvethRKYLCNFLGTIYPNSSretlietl--------------------------------------- 281 Octopus vulgaris
ELU15959     172 pse--------vdaekpRKYRCSFVGTVYANSSrsnmmqvl--------------------------------------- 204
XP_013401373 280 dti--------inamkpRQYICNFLGTVYPNSSretlmkil--------------------------------------- 312 Lingula anatina
XP_011662351 227 inq--------lnlrspRQYRCNFLGTMYPNSSrevllkvi--------------------------------------- 259
XP_029842214 227 pkd--------ldldspRPYPCNFVGTVYPKSSreellrl---------------------------------------- 258
XP_002108942 181 sme--------vditsqRRYICNFLGTVYNNSTrqklqeif--------------------------------------- 213
XP_001744677 171 pyhqargpradsahlgrRPWLCSLQATIYPNSSrsdllrii--------------------------------------- 211
XP_012565809 208 rnd--------vdlhsqRMYFCNFLGTIYSNHSlssrsklfni------------------------------------- 242
XP_004347843 266 dlaq-------lrldqpREYTCNMMATLHVNTTrellvralersalvatdetpsvdairasafqyltaelgpgherlsqe 338

Q08CD5       286 ---------kqnnmekdCLMHAREKWLPQETSDTSRQYQMALAQSDLTLCPVGVNSECYRIYEACAYGSVPVVEDVLTPG 356 Danio rerio
XP_029641869 282 ---------kssqhgkqCYYRVRHEWSPKETEDSRDDYLRSLAQSDLTLSPVGVNTECYRIYEALSYGSLPVVEDVMTSG 352 Octopus vulgaris
ELU15959     205 ---------tdpliqqqCYVRPRYKWQPNENPKSLSMYIHSLQNSDLVLNPIGMNSECYRIYEALSYGSVPVIEDIMTPG 275
XP_013401373 313 ---------tahnmgnlCYLRPRYEWLPLESEDTRQDFIQALKTSDVTLNPVGKNTECYRIYEALSMGSVPVVEDVMTPG 383 Lingula anatina
XP_011662351 260 ---------ndnnlqkyCYLKTRQRWEPDESKASLQTYINVVLQSDLTLSPVGMNAECYRIYEACALGSVPVVEDVTTKG 330
XP_029842214 259 ----------lgdrgapCYMRARSEWRPLETKDSLESYLLALKLSDVTLNPAGMNPECYRIYEALEFGSVPVLEDRTVSP 328
XP_002108942 214 ---------lknslgdiCYSNFRPRWLSMETKASSLLYQKVLRQSDITLCPIGFNSETYRIYEACSLGSIPVIEDVVAPG 284
XP_001744677 212 ---------dqqglrehCFVEARMTWQPNESSESRQQYTQALLTSDYTLAPAGLNTECYRWYEAAAAGSIPIVEDVTQPP 282
XP_012565809 243 --------ltvgrlktlCYTKVRYSWLPAETKETFELYHKILKQSDLTLCPVGFNSESYRIYEAMSYGSVPVIEDVMTHG 314
XP_004347843 339 hltdknllanypapvrsCLVANRANWAAQDSKEETQHYHEALLTSQFTLCPKGLNVMCYRIFEACELGSIPIVEDVPTPE 418

Q08CD5       357 Acavg-----nrsPLRLLKDAGAPFIFLKDWk-ELPVILEREramsQKEKTERRMRLLEWYSSFRQQMKDRFTEVLEENF 430 Danio rerio
XP_029641869 353 Ncghsv--sskniPLRLLKESKAPFIYVKHWs-ELPALLEKEaamsQVQKANRRRHFIQWYEDFKSKMRDVLVRTLQEKF 429 Octopus vulgaris
ELU15959     276 QcgtgesdpsvaaPLRLLKELGAPFIYVNDWs-ELPSILQQEamktQAEVVMRRKKVLLWYRKFKRTVKFKFLDRLHDLF 354
XP_013401373 384 Ncgksk--vshnaPLQLLKEYGAPVIYVKKWe-ELPDILKAEqkmsISKVIERRTRVLNWYKEFLLKTEEYFVGILKDRF 460 Lingula anatina
XP_011662351 331 Dcs--------psPLRLLKKLEAPFIFIKDWs-ELPGILDAEmkmsIEEIVDRRRRLVAWYETFKYKMKDILMRKIGEVF 401
XP_029842214 329 Gcara----adggSFRLLKAQGAPVLYVRNWtsELMPLLEREvamaPAERADRRRRLVAWYGSFKRAMRDRLLRVLAEKF 404
XP_002108942 285 Ncdss----lsssPFRLLKKLKAPFIFIKDWs-ELPAIIRKEsamsENDKIIRRKLLLHWYHSFKIYLRNHYIKTIKENF 359
XP_001744677 283 Tcg--------rdPLALMKEHGAPFIYIKTWs-ELPELLARLqqrpPAELVAHRRRLVEWYEGFRLAMRYRFCSAAVRAF 353
XP_012565809 315 QcskdfssdkhgaPFRLLKTYNAPVMYVHDWs-ELLSIIELEskmpHVEKVKRREAILRWYEKFRSKMRDVFLEVLSKRF 393
XP_004347843 419 Cgpe-------fnQLTLLKAHNAPFIYVRDWn-NIAAVLDNEla-dKAAVLKRQRDVVEWYATFKTAMRDKFMSVLLNSF 489
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