6N86


Conserved Protein Domain Family
Ric8

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pfam10165: Ric8 
Guanine nucleotide exchange factor synembryn
Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.
Statistics
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PSSM-Id: 462973
Aligned: 97 rows
Threshold Bit Score: 223.227
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6N86_B        86 WLQSIRILSRDRSCLD-SFTSRRSLQALac---------------------yaGIsasqgsvp-----eplnmdvvLE-- 136 cattle
XP_002055343  66 CLNTVRILTRDEFSLQ-THFVEQELGTLls---------------------laRInassnedgaqpqlddaqaeviAE-- 121
XP_002121749  71 ALSVLLFLSRDRELVSkCLASADFTKYLlk---------------------hsKLngapiatdt---dgdvelnlkIEll 126
EDO46011       1 -LNALRILSRDKNGLG-LLTSEKSSKALtcigptevdtvylrmmnydgcvktsGTi--------------------IE-- 56 
EFO26882      67 ILRFLRILARDKQNLD-QLLSSGLVQDVlg---------------------vgLLterlfe---------fdwesfIQ-- 113
Q9GSX9        65 LLETIKILSREKDGLE-GLLNDPLCDKIla---------------------faELssnenns--------ktvhtlME-- 112 Caenorhabditis ...
EGT48653      66 LLETIRLLSRDRNGLE-GLLNVDLCNKVla---------------------faGLqtgegvp--------knphalME-- 113
XP_003091664  66 LLETVRLLSRERDGLE-SLLNNDLCDKIlr---------------------haALkwedgyp--------ksvhalME-- 113
CDS39817      54 AIVCLLILSRDPDYQK-RLSECDMLHLLfr---------------------eaAIlpdspk---------ppdeciVG-- 100
XP_018644182  51 CLCCLRILTRDNILRK-ELTSEFFLSQVf-----------------------kYAfeyncnl--------eysktsLE-- 96 
6N86_B       137 SLKCLCNLVLSSPVAQALaaeaglvvrLAERvglc--------------------------------------rqsSFPH 178 cattle
XP_002055343 122 ALKCLCNLVYQSADCRRQclrqhsldvLVKRlgta--------------------------------------sstRYPC 163
XP_002121749 127 ACKCLCNVLFITNDANDTftdhqflksVTEKive----------------------------------------hqSRPD 166
EDO46011      57 SLKCLCNIMYHSAPAREHcikfdvtlsLLHRlknw--------------------------------------adkSVPQ 98 
EFO26882     114 AEMCLINILFNSKLARDEfnei-asdlLLSRirllsetsrssskqrnnddiratekdigisakpkifeslveflnnEQID 192
Q9GSX9       113 AQKCLINTLFHSQRMRDRfyanpktgeNLQFflgefeenrrkt----------------------ssidwirllnpVQAA 170 Caenorhabditis ...
EGT48653     114 AQKCLINTMYHSQRMRDVfyateenseNLLFyllefspqnrkt----------------------sehqwiremheVQAA 171
XP_003091664 114 AQKCLVNTMFHSAKMRDRfyldsqnseNILQflsefdesqrke----------------------skiewiremnqVQSS 171
CDS39817     101 ALKCLSNVIFKNPEVIQDlrlkhcldaLLDRceaq--------------------------------------ikgSPNF 142
XP_018644182  97 ALKSLSNILFKESCVIEPlktmgliksVMESvdil--------------------------------------ietENNE 138
6N86_B       179 DVQFFDLRLLFLLTALrTDVRQQLFQELQGVRlLTRALELTLGMTEG-ERHPELLPPQETERAMEILKVLFNITFDSIKR 257 cattle
XP_002055343 164 TLEYYDMKLLFLLTALePTARTRLQIDLNGLTyMTKWLDDKLADSAT------AASEEQLNIICELLKVMFTVTS-APDK 236
XP_002121749 167 EHTVITLRLVFLITALsAKGRNLFIENHNARTvLVQFLEYKINQVNDtDREGKVFTPKQVEVVDEILKVLFHLNVDLRKS 246
EDO46011      99 DVFYFDLRLMFLLTAFeGAIRKTAFEN-KGLCiLTHALDSQVPGKDD----RDRTHSSNGKDGSEILKVIFNVTMAMPKE 173
EFO26882     193 LVAFYDLRIAFVASAQsKDLQLYWLKDGCEV--FLKILEQSLHFPER--LKQNSRWRSFAEHTNWALKILFNIFCYSRDD 268
Q9GSX9       171 EIWYFYHRIAFIATALgREFQKNWANDPKTIDsLLLAVEICTNRSEN--------STQDINRATEALKTFFNVFCHFHGD 242 Caenorhabditis ...
EGT48653     172 EVWFFYHRIGFISTAMsRDFQKKWANEPKMIDnLLPAVEYIIEKKDF--------ISQDRERANEALKTFFNIFCHFHGE 243
XP_003091664 172 EVWYFYHRIAFIATAMnRDFQKSWANNPQMIDhLLTAVRCVLGKTSV--------PQIDLLRANEALKSFFNVFCHFHGE 243
CDS39817     143 QIALFDLKVLFLCSALeSASRLEILTSRFESDiFVNLLRWTLASDFS-------VHPQMFDITIETLKLLFNLSYAKKER 215
XP_018644182 139 R-LLLCLKLLFLVTALdSASRQELIKS-NALQmLMKIVKMKSSKITD------------LNVSAEALKVVYNILYSTRDD 204
6N86_B       258 EVDeed-aaLYRHLGTLLRHCVM-LAAAGdrte-elhGHAVNLLGN-LPVkcldvlltlephEGSLEfl----------- 322 cattle
XP_002055343 237 SPNey--eiQSLHLTGVLRELLLrFGRLStereraivTHAINLLTN-ISDsclteltlkcnsADTETesvkectvasgtt 313
XP_002121749 247 SMYstqevsDLDLTLSLCRTVLL-STCEDekrteslhCHAGNAIYSvPPQqlkmklligeksEQVQEesl---------- 315
EDO46011     174 LTHet--qeHYERIALITSTLFT-HVKALpdgaenvhNHAMNAINS-MPKeamhflywgfpkSVGKAf------------ 237
EFO26882     269 SVEs-----NAKQCMLLCSKIVT-LENIDpsl----eqsAVDVIAV-FPLsfell--tpkiqHTEKKdtnv--------- 326
Q9GSX9       243 VKAid--hkNAAKTCQILRDAIC-SDVLTddv----vqsAIHCLSV-PPLpmvlsvlcgknsKNNGGeneeek------- 307 Caenorhabditis ...
EGT48653     244 VQAid--qkHAIKATRILRDIIC-SDRSDdel----imsAVHAVSV-PPLpivlsvwcqdpeKDAKAtaeddev------ 309
XP_003091664 244 VEAin--kkKAMEACEVLRDTICsVDIVGddv----iqsAIHALSV-PPLpmilsvicgdptVPLDTtssidnqs----- 311
CDS39817     216 DYDqrlyesTYRDLTTVIRELLV-KFVEPrerrmelvSHSVNFLTS-VPSacyvgllfpssnVDDSLrsgdf-------- 285
XP_018644182 205 VTKel--gdDIRNLVVMLRCILQ-DPMLSefnsyalvSQVVNVLNI-IPKhlykhlldgnfnDHATDnlikds------- 273
6N86_B       323 --------------gVNMDVIRVLLSFMEKrlh----------------------qtHRL--------KESVAPVLSVLT 358 cattle
XP_002055343 314 epqpaskccalcfekRNVRSLAVLLDYLRGglaq-------------------qeteASS--------HELLSPVLTVLV 366
XP_002121749 316 ------------rktERFAPIKSLLYILEHrvmn------------------------------niitVDVLQPLLALLS 353
EDO46011     238 --------------tNNMAAIMSLLKHIESrid----------------------ssN----------ADSLVPEISALC 271
EFO26882     327 -----------ihggRDMTFANAVLHALERrlea--------------------ennEK---------NELLGTFLTVLI 366
Q9GSX9       308 ---------ffveelSNMQLTEAILMHLDKqltkvvalllndapnqqqnpmlsaeasTL---------TDLVGPYFQVLA 369 Caenorhabditis ...
EGT48653     310 --------vdlfreyDDMKMTEALLSSLDKqltvavkmlnn-----tphdkvsteanTL---------CDLIGPYFQALA 367
XP_003091664 312 --------ieeerefKNMTMIEALLMALDKqlaravallns-----tpndqvsqeanTL---------TDLTGPYFQALA 369
CDS39817     286 -----------htdpQVTRALSVLVEFLTYqld----------------------qdDKSps----rsGHLLSPILTVMA 328
XP_018644182 274 ---------apenktNGMSSIETLIDFLHSqlkl--------------------dagKESetasdirtDERICPILNCLT 324
6N86_B       359 ECARMHRPARKFLKAQVLPPLR--DVRT---RPEVGELLRNKLVRLMTHLDT-D--VKRVAAEFLFVLCSESVPRFIKYT 430 cattle
XP_002055343 367 KCARSDRTMRHYLRKEILPPLK--DVSK---RPEIGNELRNHLCRFLTLPAM-I--LRDLAAELLFILCKEDVGRMIKYT 438
XP_002121749 354 QLSRCSADVRKALKAEILPPRK--DFHR---RPEDGDALSNKLVKLCTHANV-E--VKNGIADFLFVLCKENVDRFVKYT 425
EDO46011     272 CLAKGDSIIRKYLRLEILPPLQ----AVshtRPEEGSAIKNKLIKMMTAPGD----IRDMVADFLFILCKENTDRLIKYT 343
EFO26882     367 RLSSQVKEARRYLRLLVIPPLHatDVER---RPDDGIELRNRMIRLMMSISN----IQDLAAEFIFILCKKSVNRFVKYC 439
Q9GSX9       370 RLCTDSKYVRRYCRIRVIPPLVseEVQK---RPEENNTLRGRIARIMMLPSS----TKDVAAEFLFIICKRSVNRMIKYL 442 Caenorhabditis ...
EGT48653     368 RLCVESKHARRYCRIRVIPPLVadEVKK---RPEEHDSLRGRIVRIMMLPSA----TKDVAAEFLFIICKRSVNRMIKYF 440
XP_003091664 370 RLCVESKHVRRYCRIRVLPPLVadEVKK---RPEEHNSLRGRIVRIMMLPSA----TKDVAAEFLFIICKRSVNRMIKYV 442
CDS39817     329 TASKVNRTIRKYLRMRLLPHLGa-DVKR---LPETGNTLRNRLCSRLTAKANlDdgTVEAVALLIFILCKEKVDRAVKYS 404
XP_018644182 325 RASKSNRQIRKFCRLKVLPYLGk-DVKR---LPEDGDNIRNYLCKLLTHPVQ-I--VGESAALFIFVLCKENIGRAVKYT 397
6N86_B       431 GYGNAAGLLAARGLMAggrpeg-----------qysedeDTDTDEYKEAKASINPVTGRVEEKPP-NPMEGMTEEQKEHE 498 cattle
XP_002055343 439 GYGNAAGLFAKRGVLDcrriega---------dyssdseDSDTEEYKQQQQSFNPVLGCVEQPKR-NPLEGMTEEQKEYE 508
XP_002121749 426 GYGNAAGLLAARGLLAggfgete----------ysdcdsDSDTEEYKIASHQINPVTGHVQPPQN-NPMEGMSDEQKEYL 494
EDO46011     344 GYGNAAGLLARKGLMAggqgngg---------eyssdeeNSDTDEYVQVKNQIDPIIGAIPPDRP-NPLDGMTDEEKEEE 413
EFO26882     440 GFGHAAGLLANRGILNalntpk-----------hhsdseASETEDYKAVETQVNPVTGCIDPAVE-NPFTGMTEEQKEYE 507
Q9GSX9       443 GFGHSAGHLANLGLLGqinqpk-----------hasdseDSETEDYNQIKDSVNPVTGAIYPSDHgSALAGMSEEQKEYE 511 Caenorhabditis ...
EGT48653     441 GFGHSAGHLANMGLLGqinqqk-----------hasdseDSETEEYNQVRDNVNPVTGAIYPEDHgSALAGMSDEQKEYE 509
XP_003091664 443 GFGHSAGHLANLGLLGqinqpk-----------hasdseDSETEDYNKVKDCVNPVTGAMYPPDHgSALAGMSDEQKEYE 511
CDS39817     405 GFGNFVGFLSRHGLMApsggrggd-------dayssassDSETEDYRELKDQINPVTGRVEPPRC-NPMEGLSDEQKEFE 476
XP_018644182 398 GFGNFAGFLARHALLGkpskvnresncnvesdeysatstESETEEYKRLKEDVNPVTGRWEIPQP-NPMENMSEEQKEYL 476
6N86_B       499 AMKLVNMFDKLSRH 512 cattle
XP_002055343 509 ALQLVNLLEKLRKD 522
XP_002121749 495 AVKLAQEISQLSRL 508
EDO46011     414 AMKLGEMIEHLNKM 427
EFO26882     508 VHRLMNDINKLMNQ 521
Q9GSX9       512 AMKLVDAMNQMMET 525 Caenorhabditis elegans
EGT48653     510 AMKLVDAMNKMMDA 523
XP_003091664 512 AMKLVDAMNKMMET 525
CDS39817     477 AMQLVNKIDQLQRS 490
XP_018644182 477 AMDLVQKIDKLERS 490
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