Conserved Protein Domain Family
TEDC1

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pfam14970: TEDC1 
Tubulin epsilon and delta complex protein 1
This family represents the tubulin epsilon and delta complex protein 1 (TEDC1). This complex is required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F.
Statistics
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PSSM-Id: 464414
Aligned: 33 rows
Threshold Bit Score: 98.5612
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_025049302  48 GYGRSEFYQLPS-DG--SVGSRELLLAFSWLLHRINLLEQL---------LSVNRVKI--RDET-------SLC-Tgdsk 105
VDP54840      89 GFPLIRK-NVDE-----SFTSRQLLLGSIWILVSFDVLQKVeqilistafGMTEKIFVhqNEQIftc-pgsNVS------ 155
ESO86149      86 GYLLPDFACLSN-HG--NTGSRELLLALGWLMCQQNILEKF---------MQKCSSPLd-dDTSifyesylDTD-Nkhsa 151
RUS71910      90 GYLSDSFAKLPN-DF--STGSRELLLALGWVIYQQSFINKI---------IKRRSCPLhqDFVKfsksksgILKsPeeqs 157
XP_023931041  86 GFTSVDFNLLPA-DM--STGSRDLLLAFGWLMCKEGIIDKF---------MESCASPLa-eDTIgly---meeL-Gdgvp 148
ELT99332      86 GFFSNDLSHPSS-LA--KCGSRELLLAFAWLLCREDIITRF---------MQKCTSPLqeQDTAflyaqerKFL-Asem- 151
2_pfamImport   1 GYVSRLG-FYQSgDDvlGLGSRELLLALGWVVLQYDIVERVglmc--vqrLAHPLLPLkePMNGlledtnlLLDgFksqm 77 
PNF21616      76 EYNSIEFYCLPQ-DM--SFGSRELLISVGWLMLTSNVLEIS---------TNRKLRESpmNMEFdvegy----------q 133
OXU25979     114 QYSCLEIYSFST--H--NSRSRVLMVALTWLITKYNVLGNV---------VRLKLLHSslGREFskvs--tdsTaEtnda 178
KOX78246      82 QYPAIEFYALSE--K--SKNNRPLLLAFAWLLGTQDILNII---------IRINLSNSvlGRECsqln--sveKkEtqyn 146
XP_025049302 106 lgeCgd-----nLL--KSWkgmtelapepglknevD--------IRYLQWLNGRLRFQWRSLHVDYQEQCKLLYKIHVYT 170
VDP54840     156 --------------------------------------------IPRLIWLLGRLRIHLKKLYHLKSETMRDFLK----- 186
ESO86149     152 l------fqssyKIepQAK-------------------------IQKLLMLNGKLQLNLRRMYALQIQDANLSHKIHTCT 200
RUS71910     158 t------------------------------ksrcDnlmclkekIQYHMMLTGKLRMSLRRLYSTYQQLTSFTYCIHQST 207
XP_023931041 149 dvlDdshlsprsRTdpVRK-------------------------VKQLLWLNGKLRLSLRNLYALQRERAKLMHKLHQST 203
ELT99332     152 ----------petTnpVSR-------------------------VRQLLWLNNKLQLSLRSLYALNREKMSLQHKIHGAT 196
2_pfamImport  78 eeiRkemhenslTLs----------------------------sIERLVWLKGRLDKELRTLNRISHTCQKLSTRISEYT 129
PNF21616     134 qsrDvpsqpvfkAGslECT-------------------------LNSILWIAGKIRHNVNSITETCQARVKFATKVHEST 188
OXU25979     179 klsTv-----------SNQ-------------------------MNNLLIKAHKLSNNLKAISELNVEKVKLMTRVHAAS 222
KOX78246     147 vpeTf-----------NAQ-------------------------INNILYLNGK--------------KAKLVNRIHAAS 176
XP_025049302 171 NGSHMDQTVGHFSVTETDL-------IR-QPDNYK---------QLMQLLESETSRLEAFLEWKQLE----PVYWQWMET 229
VDP54840     187 -----------LSIERPKLlppshywVLlDPNDLR---------QHIHNVQKSVSKLHLLLSWRDVN----HRFWQWVRS 242
ESO86149     201 NGVTLSTYRNHLTPFEVRL-------LR-YPNHLK---------KMLELLEKDNYRLQNLLLWKEKE----HIFWSWMES 259
RUS71910     208 EGVHLQSAFNHLTPLEVHV-------LR-HPGSLK---------KMLHELEKDNLELTHLLEWKQKE----NVFWEWMGS 266
XP_023931041 204 NGISLDPEKNHLSMLEVYM-------LR-HPELLK---------KNLQLLEKDNIRLQNLLEWKSKE----DIFWKWMES 262
ELT99332     197 SGVSVVPEKNHLSMLEVFM-------LR-KPELLK---------KNLQLLVKDNERLQNLLKWRENE----DVFWRWMES 255
2_pfamImport 130 YSSKD----SPLSLQDLYF-------LR-HGERLK---------AYLKESETSLMLLKQCHEWSNDGgrarTVVSNWFNS 188
PNF21616     189 INCCGLP---HLSVSETKL-------VR-YPELLP---------VYLDRISEYVVLMDTHKQWLKKC----HVFWEWMET 244
OXU25979     223 ITTSGLP---HLTVSEMAL-------IK-NMAVkknnn--eaelQRIKEMEKTASMLDISMKWSKKS----HVFHTWMNT 285
KOX78246     177 VNVSGLP---HLSVSEAAL-------IK-RVSTTNknalsnedkIYIKELSTIASLLDVHMKWSKKK----HVFFEWMVT 241
XP_025049302 230 VLD 232
VDP54840     243 ILV 245
ESO86149     260 VLE 262
RUS71910     267 VLS 269
XP_023931041 263 VLD 265
ELT99332     256 VLD 258
2_pfamImport 189 VLE 191
PNF21616     245 VVA 247
OXU25979     286 VLD 288
KOX78246     242 VVQ 244
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