1NRJ,2FH5


Conserved Protein Domain Family
SR_beta
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cd04105: SR_beta 
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Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP)
Signal recognition particle receptor, beta subunit (SR-beta). SR-beta and SR-alpha form the heterodimeric signal recognition particle (SRP or SR) receptor that binds SRP to regulate protein translocation across the ER membrane. Nascent polypeptide chains are synthesized with an N-terminal hydrophobic signal sequence that binds SRP54, a component of the SRP. SRP directs targeting of the ribosome-nascent chain complex (RNC) to the ER membrane via interaction with the SR, which is localized to the ER membrane. The RNC is then transferred to the protein-conducting channel, or translocon, which facilitates polypeptide translation across the ER membrane or integration into the ER membrane. SR-beta is found only in eukaryotes; it is believed to control the release of the signal sequence from SRP54 upon binding of the ribosome to the translocon. High expression of SR-beta has been observed in human colon cancer, suggesting it may play a role in the development of this type of cancer.
Links
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Statistics
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PSSM-Id: 206691
Aligned: 23 rows
Threshold Bit Score: 159.409
Created: 22-Jul-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:GTP/Mg2+ binding site [chemical binding site]
Evidence:
  • Structure:1NRJ: Saccharomyces cerevisiae SR-beta binds GTP and Mg2+, defined using 3.5 A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #######                 #  #                                #           
1NRJ_B     13 PSIIIAGPQNSGKTSLLTLLttd-----svrPTVVSq---EPLSAADyd---------gsGVTLVDFPGHVKLRYKLSDY 75  baker's yeast
2FH5_B      8 RAVLFVGLCDSGKTLLFVRLltg-----qyrDTQTSi--tDSSAIYKvnnn------rgnSLTLIDLPGHESLRFQLLDR 74  house mouse
NP_506245  39 NRVLFVGLMDCGKTTIFTQLsqkeaeyptttKTYTSm--vENKITLRik---------dkEKEIIDYPGNDRLRQKLIEN 107 nematode
AAH54231   58 RAVLLVGLCDSGKTLLFNRLltg-----tykKTQTSi---TANSAAYkvks-----dkgtSLTLVDLPGHESLRHQFLEQ 124 African clawed frog
AAT27267   73 KDFLLTGLSESGKSAIFMQLihg-----kfpATFTSi---KENVGDYrtg--------saSARLVDIPGHYRVRDKCLEL 136 fruit fly
AAH76224   61 NAVLLLGLCDSGKTLLFTRLllg-----kfvRTQTSi---TESSATYksks-----ergnSWTLIDVPGHESLRTQIVEK 127 zebrafish
CAG32188   51 RAVLLLGLCDAGKTLLFARLltg-----ryrDTQTSitdsSAVYRVSndk--------gtNVTLIDLPGHESLRLQFLER 117 chicken
AAV43791   57 NTVLLSGLTGSGKTVLFYQLrdgs----shqGTVTSm---EPNEGTFvlhsentkkgkikPVHLVDVPGHSRLRPKLEEF 129 thale cress
EAA11816   49 SAVLFTGLCDSGKTYLFAHLclg-----garETFTSi---KENVGSFkte-------rgrVLKMVDVPGNERLRGKFFDE 113 Anopheles gambiae ...
AAW41695   88 ATVLLVGPSDGGKTSLFTKLihd-----iypQTHTSi---VPSDTTFdfdspy-eddqkkQIRLIDIPGHPRLRDEVKKY 158 Cryptococcus neofo...

Feature 1                                                               ## #                  
1NRJ_B     76 LKTrakfvKGLIFMVDStvdpkklTTTAEFLVDILSITESsc------enGIDILIACNKSElft--arPPSKIKDALES 147 baker's yeast
2FH5_B     75 FKSs---aRAVVFVVDSaafqrevKDVAEFLYQVLIDSMAlk-------nSPSLLIACNKQDiam--akSAKLIQQQLEK 142 house mouse
NP_506245 108 HLHsr-slLRIVFVVDSaafsknaRDVAELFYTVALENVD----------KVPILIACHKQDlsl--akTEKVIRNSLEK 174 nematode
AAH54231  125 YKAs---aRALLFVVDSsafqrevKEVAELLYQLLTDVAVlk-------nAPPILIACNKQDism--akSAKLVQQQLEK 192 African clawed frog
AAT27267  137 YKHr---aKGIVFVVDSvtahkdiRDVADFLYTILSDSATq---------PCSVLVLCNKQDqtt--akSAQVIKSLLES 202 fruit fly
AAH76224  128 YKDv---aRAIVFVVDSsifqkdvRDVAEFLYSILTDSILak-------nAPTLVVACNKQDitm--akSAKLIQQQLEK 195 zebrafish
CAG32188  118 FKAa---aRAIVFVVDSvafqrevKDVAEFLYQVLVDSTVlk-------nAPALLIACNKQDvtm--akSAKLIQQQLEK 185 chicken
AAV43791  130 LPQa----AAIVFVVDAleflpncRAASEYLYEILTNANVvk-------kKIPVLLCCNKTDklt--ahTKEFIRKQMEK 196 thale cress
EAA11816  114 YKNi---aKAIVYMIDSvtvqkdiRDVADFLYTILVDKATs---------KVPVVVLCNKQDetl--akTETAIKSMLEK 179 Anopheles gambiae ...
AAW41695  159 IADs----AGVVFVVDIqgivrnaSGVAEQLPPILTALSNissrlppsapPPKLLLLAHKADllarptpSPSHCPPEIPS 234 Cryptococcus neofo...

Feature 1                                                           ##                        
1NRJ_B    148 EIQKVIERRKKSLNeverkineedyaentldvlqstdgfkfanleASVVAFEGSINkrk-------------isQWREWI 214 baker's yeast
2FH5_B    143 ELNTLRVTRSAAPStldssstapaqlg------kkgkefefsqlpLKVEFLECSAKggrgdt------gsadiqDLEKWL 210 house mouse
NP_506245 175 EIGLINKSRAAALIgtdgseekrstlt-----dtgidfkwedlkkQEVSFVSTSSNse--------------dfGVHEIA 235 nematode
AAH54231  193 ELNTLRVTRSAAPTtlegsnsgvaqlg------kkgkdfdftqlpMKVKFLECSTHdskeed------gdanisNVEGWL 260 African clawed frog
AAT27267  203 ELHTVRDTRSRKLQsvgdedgsksitl-----gkpgrdfefshiaQNIQFAEASAKdte-------------ldPLTDWL 264 fruit fly
AAH76224  196 ELNTLRLTRSAALSsqdgavggsvylg------kkgkdfefsqlaNRVEFIECKARgskted------gdadidALEKCL 263 zebrafish
CAG32188  186 ELNTLRVTRSAAPTsldasatggpaql-----gkkgkdfdfsqlpMKVEFVECSARgskgee------gdadfeDLEKWL 254 chicken
AAV43791  197 EIEKLRASRSAVSTadiandf------------------tigiegEVFSFTHCSNKvtvaeas----gltgetiQIEDFI 254 thale cress
EAA11816  180 EINIVRQTRRSQLQsvdnssssdtflg-----ksasvdfefeqlgQRVRFVPCSAMeeq-------------faGLTKFL 241 Anopheles gambiae ...
AAW41695  235 STLTTSTDRLKSILtremdrlkstragtggkiegigkvagtsggfFSKLFGGGAGDvagedegdddesliwggkGPFKWE 314 Cryptococcus neofo...

Feature 1        
1NRJ_B    215 DEK 217 baker's yeast
2FH5_B    211 AKI 213 house mouse
NP_506245 236 SFV 238 nematode
AAH54231  261 AKL 263 African clawed frog
AAT27267  265 ARL 267 fruit fly
AAH76224  264 AKL 266 zebrafish
CAG32188  255 AKI 257 chicken
AAV43791  255 REY 257 thale cress
EAA11816  242 DTL 244 Anopheles gambiae str. PEST
AAW41695  315 DVE 317 Cryptococcus neoformans var. neoformans JEC21

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