Conserved Protein Domain Family
Commd2
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cd04750: Commd2 
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.
Links
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Statistics
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PSSM-Id: 240098
Aligned: 15 rows
Threshold Bit Score: 174.039
Created: 12-Feb-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001002421  26 EFGRIAVEFLKKGSNPKIYEGAARKLsv---ssESVQHGVEGLMFLLTESSKLMISEldfq---dsvlVLGFPEQLNDLL 99  zebrafish
XP_312546     26 EFCKLAIEYINSGINEKKCTVAAKKLst---tyETVRGALEALVALLIDSTKLALSErefht-vvqaaLETINEKQTEIL 101 Anopheles gambi...
XP_639903     26 EFCKIALEFIKKGSNKKLYMGASQKLni---aaDKIESLVDSITYLFSECTRFMLNEndfn---dtlaPIKLSDEVIEIL 99  Dictyostelium d...
XP_001120781  26 DFCKLALDYLQKGPNIKLYNAAAQKLev---evNLIKNSVEGLVNLLIESCRYKLNSedfr---dsiiSLGFSEQQEIIL 99  honey bee
EAL29125      26 ELCKSAFDYLINGPNASRYETLAKKYsadavdrEAVQRTVEALISLLISVTTRVGGTgvdmrailrqtFPDLSDDVLEVL 105 Drosophila pseu...
EAT40957      26 EFCKLAIEYINSGINEKKCSIAAKKLdt---tfETIKTCVEALVCLLIDSSKLHITEeefl----tlrSLQFTDGQIAIL 98  yellow fever mo...
XP_967743     26 DFCKLAIDFLQSGPNLKFYASAAEKLsv---evDAVQNCVYGLVNLLLLSCKHKLSEadfr---dsilTLGFSPEQENIL 99  red flour beetle
XP_781013     26 EFCKIALEFMRKGIAQKVYQGAAQKLnv---daETVKHGVEGLMYLLTESARLMVSEldfq---dsiaILGFSQGLCKDL 99  purple urchin
BAD16595      26 EFGKISLNFIRKGANTKIFQGAAQKLgv---pvDTVQHGVEALMYLLTESSKYLLNEidfq---dsimTLGFGDETRSSL 99  great pond snail
CAK60830      24 KIINFAISYIVKHDTQTTLAEVLEIDe------NEADRYFRLALKLVSYFGKFKFGDrqfr---qnveFLKFKEDRKALF 94  Paramecium tetr...

NP_001002421 100 LqLYLENRKEIRQILSKLAp-SIPQYHNLEWRLDVQLASRALRHQVKPtvtMKLHLEdgak------------------- 159 zebrafish
XP_312546    102 WqFITSKRTLVDNVLRASCq-DELYFRDLEWRIEGRIASRTIRSQATPvikMKFHLDtecv------------------- 161 Anopheles gambi...
XP_639903    100 ReSYFDNRKDIRNTLQEFYp-HLDHYQNLEWRLDTQIANRSLGSSINPiylLKLITKcgsd------------------- 159 Dictyostelium d...
XP_001120781 100 SkLYNVKKDEILDTLKNIGf-KLPKYHDMEWRFEVQIASRTLLKQVAPl--ITLDLSiknsdk----------------- 159 honey bee
EAL29125     106 EqFVTSKRNFVEGSIKSANi-RAYRLVNLDWRLEVRTASRTLLEQCSVvitMKLYLHrepknenrellevddsgrseqel 184 Drosophila pseu...
EAT40957      99 WqFVSSKRSLVENILKHSSd-SELHFRDLEWRLEAKVASRSMVKQATPiiaMKLHLDsevvnehkeklqs---------- 167 yellow fever mo...
XP_967743    100 HkFYESKKAEIAQILNKLTv-NEPHYDNLEWRFEVQVSSRSLHQQVVPl--MTLDLSlktlkddg--------------- 161 red flour beetle
XP_781013    100 LgLYTENRAEIRSILGEMAm-DLPHYRNLEWRLDVELASRSLRHQTIPtvvMKLHTEdcgk------------------- 159 purple urchin
BAD16595     100 LaLYLEHRREIRDILNEMSl-DLPHYHNLEWRFDVQLASRSLRHQVSPsilMKLQTMdgdk------------------- 159 great pond snail
CAK60830      95 LqKLEANSTQLHKRLSFIEsdGMPYYKNLEWRYDIQIASRGYEEEFKPrifMKFDLEydnsre----------------- 157 Paramecium tetr...

NP_001002421 160 ----------rsaHVLQTDPATLQH-------LIQELERALAELKSNH 190 zebrafish
XP_312546    162 ---------seyrDKLHPEPVDHAP-------ETETTKQPPTRREVLA 193 Anopheles gambiae str. PEST
XP_639903    160 ---------npieHLLQTDPNNLKH-------LCNELESALNEIRTYE 191 Dictyostelium discoideum AX4
XP_001120781 160 -------deniehILLQTDPINLSY-------ITQQLEEAVQEGYSQH 193 honey bee
EAL29125     185 aamqederrhrkdLLVQTDISSLLY-------MIKTLEDALSESKTRR 225 Drosophila pseudoobscura
EAT40957     168 sdgepskqntrkeVLLQTDPTSLVH-------LIQVLEQALIDSKTHR 208 yellow fever mosquito
XP_967743    162 ------sgykkehHLLQTDVTNLQH-------ITHELEKALNESRSRH 196 red flour beetle
XP_781013    160 ----------kdvHVLQTDPVNLVH-------LTQTLEGALAEVKTQH 190 purple urchin
BAD16595     160 ----------kemKMLQTDPVNLVH-------ITRVLEEALQEMKSGY 190 great pond snail
CAK60830     158 -------cgkieqVFLETDYANLKNlqqeisyLVSQLESARQQKIKKL 198 Paramecium tetraurelia
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