4CO7,1EO6


Conserved Protein Domain Family
Ubl_ATG8_GABARAPL2

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cd17163: Ubl_ATG8_GABARAPL2 
Click on image for an interactive view with Cn3D
ubiquitin-like (Ubl) domain found in GABA type A receptor associated protein like 2 (GABARAPL2, also known as GATE16)
Autophagy is an essential intracellular process that targets large protein complexes, bacterial pathogens, and organelles for degradation. GABARAPL2 (GABA type A receptor associated protein like 2), also known as GATE-16 (golgi-associated adenosine triphosphatase enhancer of 16 kDa), has a ubiquitin-like (Ubl) domain and is a sub-family of the autophagy-related 8 (ATG8) protein family. GABARAPL2 participates to the autophagosome maturation, and seems to be involved in constitutive transport under normal conditions and in autophagic processes during stress. GABARAPL2 is characterized as a membrane transport modulator that controls intra-Golgi transport by interacting with NSF and Golgi v-SNARE GOS-28.
Statistics
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PSSM-Id: 340683
Aligned: 19 rows
Threshold Bit Score: 203.421
Created: 24-Jun-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:Atg7 interaction site [polypeptide binding site]
Evidence:
  • Comment:Atg8-Atg7 interaction site
  • Comment:The E1-like enzyme Atg7 activates the autophagic ubiquitin-like (Ubl) molecule Atg8.
  • Comment:based on the structural evidence that Saccharomyces cerevisiae Atg8p (3RUI) interacts with Atg7p

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               #     ##          #  #        ## ### ###     # ### #  ## 
4CO7_A         7 FKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDiTVAQFMWIIRKRIQLPsEKAIFLFVDKTV 86  human
XP_002111553   5 FKEEHTLEQRRQESAKIRAKYPDRIPVVVEKAAKSSIPDIDKRKFLVPSDlTVAQFMYIIRKRIQLPpEKAMFLFVNKIL 84  Trichoplax adha...
AGL72329       5 FKENHPFEVRCAESAKIRGKYQDRIPVIVEKVPKSSIPDIDKKKFLVPADlSVAQFMYIIRRRINLPsEKAMFLFVNKVL 84  Astrosclera wil...
XP_786800      5 FKEEHSEDHRTSESSKIRVKYPERIPVIVQKAPKSQVPDIDKRKFLIPADiTVAQFMWIIRKRIQLPaEKAIFLFVGKVL 84  purple sea urchin
CCD80425       5 FKETHTFEQRQQDSSKIKAKYPNRVPVVVERHRHSQIPDIDKHKFLVPDDvTVAQFMWIIRKRIDISsEKALFLFVEKNM 84  Schistosoma man...
AHI16243       5 FKEENTFEQRKAEAAKIRAKYPDRIPVVVEKAPNSQIQDIDKRKFLVPNDiSVAQFMWIIRKRIQLPsEKAIFLFVGKVL 84  Dumeril's clam ...
XP_002607439   5 YKEEHSLEQRQAESDKIRRKYPDRIPVVVEKVPNSQIQDIDKKKFLVPTDiTVAQFMWIIRKRIKLPsERAIFLFVGKVL 84  Florida lancelet
XP_002740384   5 FKEEHSIDQRRAEASKIRAKYPERIPVVVEKVPKSQIPDIDKRKFLVPADiTVAQFMWIIRKRIQLPpERAIFLFIERVL 84  Saccoglossus ko...
XP_013417177  38 FKEENTFDTRKCESAKIRSKYPDRIPVVVEKAPRSNIAEIDKRKFLVPSDiSVAQFMWIIRKRIQLPpERALFLFVGKVL 117 Lingula anatina
KXJ17679       5 FKEEHSIESRCQESAKIRSKYPDRIPVVVEKAPKSSIQDIDKRKFLVPSDlTVAQFMYIIRKRIQLPpEKAMFLFVNKVL 84  Exaiptasia pallida
Feature 1         ###                       #####
4CO7_A        87 PQSSLTMGQLYEKEKDEDGFLYVAYSGENTFG 118 human
XP_002111553  85 PTTSSTMGAIYEEHKDEDGFLYIAYSGENTFG 116 Trichoplax adhaerens
AGL72329      85 PTTSASMGTIYAENKDEDGFLYVAYSGENTFG 116 Astrosclera willeyana
XP_786800     85 PQSSATMGHIYQEHRDADGFLYVAYSGENTFG 116 purple sea urchin
CCD80425      85 PQTSATIGQLYHNFHDDDGFLYISYSGENSFG 116 Schistosoma mansoni
AHI16243      85 PQSSASMGQIYEEHHDEDGFLYIAYSGENTFG 116 Dumeril's clam worm
XP_002607439  85 PQSSANMGQIYNEHKDEDGFLYIAYSGENTFG 116 Florida lancelet
XP_002740384  85 PTTSSTMGQIYEEHQDEDQFLYVAYSGENTFG 116 Saccoglossus kowalevskii
XP_013417177 118 PTSSASMGSIFEEHKDEDGFLYVAYSGENTFG 149 Lingula anatina
KXJ17679      85 PTTSSTMGAIYEEHKDEDGFLYIAYSGENTFG 116 Exaiptasia pallida

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