7BXU


Conserved Protein Domain Family
OSTMP1

?
pfam09777: OSTMP1 
Click on image for an interactive view with Cn3D
Osteopetrosis-associated transmembrane protein 1 precursor
Members of this family of proteins are required for osteoclast and melanocyte maturation and function. Mutations give rise to autosomal recessive osteopetrosis [MIM:259700]; also called autosomal recessive Albers-Schonberg disease.
Statistics
?
PSSM-Id: 430817
Aligned: 15 rows
Threshold Bit Score: 259.222
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
7BXU_C        84 CRELLLDFANSSAELTGCLVRSARPVRLCQTCYPLFQQVVSKMDNi-SRAAGNTS--ESqsCARSLLMADRMQIVVILSE 160
XP_005802669  83 CTELLRLFGQRYVAFVNCLVPAARPVRVCQNCSPGYSSLSEVFLNisSDKLGPAN--ES--CRDSILRSDRLMLVFLLYG 158
XP_003971934 100 CRNLLGIFGQRYVASIDCFVPAARPVKVCQNCFSAYGSLGDIYVNi-SDKTGPGN--ES--CKEILLHSDRLMLLDLLHN 174
XP_002665788  73 CIELLRIYGQRYVTFANCLVFYARPVKVCQNCYTGFKGLKEIYLNisSGQ-GPGN--VS--CHDSLTRSDRLMLLYTLYS 147
XP_006626098  82 CRELLHIFAQRCISYVDCLLQFARPVRICQNCYSEIESLNNTYTNisKEN--TGN--VS--CRNVLLRSDRLQLVSVLHR 155
Q09322        42 CQKYVEKLAVVQSEMVACATNWSIPPVVCTKCFQNYINFKQFEYE--TKNLNNVYslDNrtCSQVIYDNYLLSYSTDISK 119 Caenorhabditis ...
NP_001280434  40 CQNLLQSFANETARFTLCVVTNARPITVCEKCVNEFNQVFKRYEE--IQKLHNND--SEvdCRAVLTNIDRLQVVYASYN 115
XP_001807287  25 CTELKEQFASATAEFSSCAIQNSRPVTFCENCVNAYIQIVDSYNG--MKEVPD----NGtyCIDRFVNLDRLGIVQTSYI 98 
XP_008119023  52 CRELLAGFANSSVRISGCLVRHARSVTVCQNCYRPFREVTEQLENi-SRAAGNTT--ESnpCAKSLLMSDRLQIVLIMSN 128
XP_003449914  76 CSDLLHIFGQRYVAYVNCLVPAARPVKVCQSCYSTYGNLVEIYNNisSDQMGPGN--VT--CRDSLLRSDRLMLVYQLYS 151
7BXU_C       161 FFN-TTWQEANCANCL--------TNNSEELSNSTVYFLNLFNHTLTCFEHNLQgnahsllqtKNYSEVCKNCREAYKTL 231
XP_005802669 159 SLD-TIWKKSNCKQCV--------TTDLTGPNNDTLYYLTLLNQTITCFEKYKE---------GNHTELCKNCKNAYKGL 220
XP_003971934 175 SLS-DIWTQSNCDRCI--------TTGYRSLTNDTLVFLATLNQTLTCFEKNQQ---------DNQTELCKSCKGIYGEL 236
XP_002665788 148 NLE-DIWTSAKCDQCL--------TEHEEALTNDTRYFMATLNQSLSCFEQYKD----------NHSELCKDCKPRYKRL 208
XP_006626098 156 DMN-VIWDTADCEKCL--------TFPLGSFSNDSLYFMASLNQTLSCFDKYEQq--------GNQSVVCKECKTTYRGL 218
Q09322       120 ALTsEIWEKSRCDSCItikwnfpqNKSEVSFSERTMQFQNRMYEWRNCVVNYTSggvl-ddnlTNGSKICNLCKTTFDEL 198 Caenorhabditis ...
NP_001280434 116 YVL-DMWEKASCKLCL----------NGTVFNDKTRGVMIRGDNLDKCISKHINnt------kLSNTSLCADCKQYYVNL 178
XP_001807287  99 NSY-NLWNNAKCYECFqv----vdGKLTPNKSLETIAFNKYYDNFMQCINGt----------dINDTTLCPTCIDDYLDL 163
XP_008119023 129 FFN-ATWKKANCANCL--------KNNSEGLSNSTVTFLALFNESMACFEHNLQrqed-srllGNISDVCKNCNVTYKKL 198
XP_003449914 152 NLE-SLWEDSNCAKCV--------TEHLESLTNDTLYFMATLNQTLTCFEKYQQ---------GNHTELCKNCKSAYGTL 213
7BXU_C       232 SSLYSEMQKmnelenkaepGTHLCIDVEDAMNITRKLwSRTFNCSVPC--SDTVPVIAVSVF-ILFLPVVFYLSSFLHSE 308
XP_005802669 221 NDLYSGMEK----------NSTLCIDLEDSMNMTRKLwSKNFACSLPR--EETIPVIAVSSF-MLFLPIIFYLSSFLHSE 287
XP_003971934 237 NKLYNRLDK----------SQAVCIDMEDSMNTTHRLwSTSFNCSVPR--AETVPVIAVSSF-MLFLPVIFYLSSFLHSE 303
XP_002665788 209 NELYGKMEK----------NQTLCIDIEDAMNITRKLwSKNFGCSFPR--EETVPVIAVSSF-MLFLPIIFYLSSFLHSE 275
XP_006626098 219 NDLYNRMEK----------NQTVCFDIEDAMNITRRLwSKNFNCSFPR--EEIVPVIAVSSF-MLFLPIIFYLSSFLHSE 285
Q09322       199 FGYYWKIYTt--------pDVDFCVDVETTMNDTIHLwDDVWKCAEKQdrNRDLFGIMITFGtLLLLTALFYAASYIQGG 270 Caenorhabditis ...
NP_001280434 179 TNYYNKHKN----------DNTFCMDVVDLINNTQSDwSLKWKCHESN--YESEWVLLVISFiVLLLPILFYFINWLISQ 246
XP_001807287 164 NSYYHSISNen-------eKIGGCMDMVDLINNTRQFwSQ--KCCKYR--RHDEHIFLASAItVLIVTLLFYVIAQFSSV 232
XP_008119023 199 NDMYNSMQKsgked-eseeEFHLCIDVEDAMNITRRLwSTSFNCSVHY--SDTVPMIAVSSF-ILFLPVVFYLSSFLHSK 274
XP_003449914 214 NVLYSQMEK----------NSTLCIDIEDAMNMTRRLwSKNFNCSFPR--EENVPVIAVSSF-MLFLPIIFYLSSFLHSE 280
7BXU_C       309 QKKRKLILPKRLKSSTSFAN 328
XP_005802669 288 QKKRKLIHPKRAKSHTSLMN 307
XP_003971934 304 QKKRKLIHPKRAKSYNTLMN 323
XP_002665788 276 QKKRKLIHPKRAKSSSSLMN 295
XP_006626098 286 QKKRRLILPKRAKSSTSVMN 305
Q09322       271 GETRRLIQYARLSDPHGQRS 290 Caenorhabditis elegans
NP_001280434 247 KRSNVLLSQNRWHQRFTSNA 266
XP_001807287 233 KKTPTIMQQTRFAESLSHNS 252
XP_008119023 275 QKKRILMPSKRFQSNDSSVN 294
XP_003449914 281 QKKRKLIHPRRAKSNTSLMN 300
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap