1VFQ,1UDM


Conserved Protein Domain Family
ADF_coactosin_like
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cd11282: ADF_coactosin_like 
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Coactosin-like members of the ADF homology domain family
Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. Many of these proteins enhance the turnover rate of actin and interact with actin monomers as well as actin filaments. The function of coactosins is not well understood. They appear to interfere with the capping of actin filaments in Dictyostelium, and may not be able to bind monomeric globular actin. A role for coactosins as chaperones stabilizing 5-lipoxygenase (5LO) has been suggested; 5LO plays a crucial role in leukotriene synthesis.
Links
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Statistics
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PSSM-Id: 200438
Aligned: 43 rows
Threshold Bit Score: 92.314
Created: 17-Aug-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative F-actin binding interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1VFQ_A        10 ACRAAYNLVRD--DGSAVIWVTFKYD---GSTIVPGEQGAey---qHFIQQCTDDVRLFAFVRfttg----------dam 71  human
XP_001421249  85 SFRDVANAVRA--DAGAFNWYLVRGDangASEVFNAGGGSl----dEMKKSLASDEVFFGLLRmgfg----------rga 148 Ostreococcus lu...
XP_646569      6 NQQELNNALEKynGSENGHWVLLTYKt--PTQLQFKTSGDgl---qSLGAVLQDNEVAYYKIRleynsndagfkdgvign 80  Dictyostelium d...
EEH55110      77 TVAEACEILRA--EHGTMNWLLCDLT---PETGRPRLFAAdsnglhKLTRYLAADAVFFGLIRmtfg----------igk 141 Micromonas pusi...
XP_001467101 179 QTNRVMTSLRQ--DNGSVNWVVFESN---SEVLTVRAYGQhg--ifEMVKNLPDEEWLFGLFRisfs----------nge 241 Leishmania infa...
XP_635677     10 ELREAQAALFN--INSTGGWVMLNYVg--PSTVHFAAGGEnf---eEIVNLLEDDQIQYGVLRigniee-------kgtl 75  Dictyostelium d...
XP_845501    197 TVERVLNAVRN--RLGSLNWVTFAAN---PVELCLRNAGNgg--vyELVRNLPHTLWLFGLFRitlc----------vkg 259 Trypanosoma bru...
XP_815685    176 NTRSVLEALHM--KLGPLNWATFEAN---PLHLTLAGAGNgg--ifELVKQLPAAKWLFGLFRitlg----------aae 238 Trypanosoma cru...
CAL57582     487 SFREVANIVRN--ENGAFNWYVLRADa-nGNEVVNAGGGSle---eMKSTSLPSNEVLFGLLRmgfg----------rga 550 Ostreococcus tauri
XP_654122      3 TEQEAMALMGSi-DVPNGQWVVYEVK---NKQLVFRTSGNgv---dSLRDELKDDEACFALINlrctl---------egi 66  Entamoeba histo...

Feature 1          # #             # #          #             #  # 
1VFQ_A        72 sKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKEL 121 human
XP_001421249 149 fRRVKHIFIHWSGADVNPLKRGQHNANEEAIRKLVGPVNLSHFATEMDEM 198 Ostreococcus lucimarinus CCE9901
XP_646569     81 kANTKDIFVAWTGPSVGIIEKGKKKSHVGDAKAFFQPFHSELTQTSKDPK 130 Dictyostelium discoideum AX4
EEH55110     142 rRRRKFIFLRWIGEDVSATRRRDAEEALSKMRSVLGSTSCDHFATSREDV 191 Micromonas pusilla CCMP1545
XP_001467101 242 vHQRRMIFFQWIGSSLKAMRGGSHAGVYPAMAKALSPFNYEIYLVGRQDL 291 Leishmania infantum JPCM5
XP_635677     76 kTTVRDVFFCWIGPGVGIIEKGKKTAFLGDAQQLLQPYHADITVLNKKNF 125 Dictyostelium discoideum AX4
XP_845501    260 hRMTRVVSFQWIGDQLGAVPRDSYSKVSPIIESILSPFQHEVYLVGAQDL 309 Trypanosoma brucei TREU927
XP_815685    239 eRQSLLIFFQWIGSRLRVVRQGPTTHIFPKMASILAPYEYEVYLVGTQDL 288 Trypanosoma cruzi strain CL Brener
CAL57582     551 fRRTKLVFLHWSGEDVPALKRGQLNAHEEAIRKLVGATNVNHFATSIDEL 600 Ostreococcus tauri
XP_654122     67 pDQARGIFIDWKGPKCKGIAKVRVREFKDQALEVLMPHHGELEAVGKTEF 116 Entamoeba histolytica HM-1:IMSS

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