Conserved Protein Domain Family
TLC
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smart00724: TLC 
TRAM, LAG1 and CLN8 homology domains.
Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.
Links
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Statistics
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PSSM-Id: 214789
Aligned: 57 rows
Threshold Bit Score: 86.5785
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9V3S7   127 SDVLEITNKIVSAIQASFSFFVGLIVCKs--TCTksfvyashflMEAYGWFGTAYFMYDIWSMYKVHTQKIADkLHLLRI 204 fruit fly
Q99JT6    40 LRTWRWHNLLVSFTHSIVSGIWALLCLWq--TPEml-------vEIETAWSASGYLLVCFSAGYFIHDTVDIVvSKQTRA 110 house mouse
Q9N5G9    75 LKKWRISNESVSMVHSAISGFWAAYALI---VDPel------fkSPILYHCIVGRNLVLMMTGYLLNDLVDLIcNERSVR 145 Caenorhabditis elegans
Q9XTE6   102 NKKWRISNECVSLFHSVISGLWAAYALL---YYKql------vqDLVNYRCDVAINLVLMSAGYLFHDLVDLLvNEQSAR 172 Caenorhabditis elegans
Q9BL09    35 NKTRLFAVRVVSFTHALVSALGCIFSLL----TDvny-----vrEPYDYHKANAEYVFLFSMGYFIYDLLDMHiHGELES 105 Caenorhabditis elegans
CAC88604  29 HRSYEWSCRLVTFTHGVLSIGLSAYIGFidgPWPf--------tHPGSPNTPLQVHVLCLTLGYFIFDLGWCVyFQSE-- 98  human
Q8VZR3    32 SYSFSFSNRLLSTAHATIAVTLATLSVQd--LSCpv-------cPLASKPSHKQMDVMAFSLSYMIYDLICCHfDQVF-- 100 thale cress
Q8VC26    33 RDRWMWRNIFVSLIHSLLSGVGALVGLW---QFPqm------vtDPINDHPPWARVLVAVSVGYFAADGVDMLwNQTLAQ 103 house mouse
Q9LYA1   356 QIRPEASSCLISIFHGSPAVFLATRAVFs----Sse-------rSFASANTAAQNTVLDFSVAYFLTDLFHYIvFNPN-- 422 thale cress
Q9LK26    35 ETRPLASSCLISLLHGVSAVVLATNALLs----Dpn-------rGFSSVNTQSQNSILDFSSAYFLADLVHLAvFPSPAG 103 thale cress

Q9V3S7   205 TkgqgavvsnghangkvngksasgnnngstptnlheicdydgacvqipkdgrwdflkyvvtHPVMMIHHVFIGTFGLLVV 284 fruit fly
Q99JT6   111 -------------------------------------------------------------SWEYLVHHVMAMGAFFSGI 129 house mouse
Q9N5G9   146 -------------------------------------------------------------IVELLFHHVVVLSAFTICL 164 Caenorhabditis elegans
Q9XTE6   173 -------------------------------------------------------------IIELLFHHVVVLSAFAVTM 191 Caenorhabditis elegans
Q9BL09   106 -------------------------------------------------------------SKEYLIHHSLVITAFSIIL 124 Caenorhabditis elegans
CAC88604  99 -------------------------------------------------------------GALMLAHHTLSILGIIXAL 117 human
Q8VZR3   101 -------------------------------------------------------------SIDNAVHHFVSILGFIAGL 119 thale cress
Q8VC26   104 -------------------------------------------------------------AWDLLCHHLAVVSCLSTAV 122 house mouse
Q9LYA1   423 -------------------------------------------------------------DVLFIGHHVATLFVFLTCR 441 thale cress
Q9LK26   104 G------------------------------------------------------------DSLFAAHHLAVLFVFLTCR 123 thale cress

Q9V3S7   285 TYIRGGGHCIysYMFMMEFSTPFVSLRSILSTMRlk-----dSRVYIANGLLMLATFFVCRVCMWPYVMWRYSLAIEAAS 359 fruit fly
Q99JT6   130 FWKRFVGGGV--LTLLVEVSNIFLTLRMMMKINNaq-----dLLLYKVNKYINLVMYFLFRLAPQAYLTKFFLQYAGQRT 202 house mouse
Q9N5G9   165 FYDLMLGIVV--AGLLMELNSIFLHIRSLMNLYGfd----kkLTAFRVTVILNIITLVVFRLIVNVYMIYFVFASFSMSP 238 Caenorhabditis elegans
Q9XTE6   192 FFNRFLGVVV--FGLLMELNSIFLHSRSLLNLYGvd----kkSPSFRIIALLNMVTLFAFRLCVSAYLVYFVVVSIPDLE 265 Caenorhabditis elegans
Q9BL09   125 LSGRLFGLAM--IALLVEIQTVFLHLRTMVRLLYgsk---hmPASIDVLINANMICLFLFRHLPVCYLLFYLIAQDVKVP 199 Caenorhabditis elegans
CAC88604 118 VLGESGTEVNa-VLFGSELTNPLLQMRWFLRETGhy-----hSFTGDVVDFLFVALFTGVRIGVGACLLFCEMVSPTp-- 189 human
Q8VZR3   120 AYQKSGSEIVa-TLWVAEISSPFFHLREILKEIGyk-----dTKLNLAADVCFATIFTLARIVCGPFLVYVSLSADN--- 190 thale cress
Q8VC26   123 VSGHYVGFSM--VSLLLELNSICLHLRKLLLLSHka-----pSLAFRVSSWASLATLVLFRLLPLGWMSLWLSRQHYQLS 195 house mouse
Q9LYA1   442 FLVFHGACAIlgLLILAEVTSACQNAWTLAGARKndpesrlaVKVYDLLSPPFYAFYSIVRGVLGPLFFGKMVAFYARGG 521 thale cress
Q9LK26   124 YMVAHGACALlaLLVVAEATSACQNTWTLADARGkda--plaVSLHRFVTVPFYASYSVCRCVLAPLLIVKMTWFYVSGG 201 thale cress

Q9V3S7   360 LWS----AMWGLPRGCLISIAILFLPQLYWFYLMVLGALKVFL 398 fruit fly
Q99JT6   203 LG-----------TFLLAILLMLDLMIIIYFSRLLRSDFCPER 234 house mouse
Q9N5G9   239 WY---------IASTICVLILCLASSNMVLTYRLLAADGFCGA 272 Caenorhabditis elegans
Q9XTE6   266 WYV---------SIINGLVIASLASTNTVLTYRLLAADGLLGS 299 Caenorhabditis elegans
Q9BL09   200 ILLklflVGGLTFLEYHNTHLTMAMAKSDGFFGHERQALDEDS 242 Caenorhabditis elegans
CAC88604 190 -------KWFVKAGGVAMYAVSWCFMFSIWRFAWRKSIKKYHA 225 human
Q8VZR3   191 ------------PIFIKAMGSGLQLVSIFWFYKIFGMMRYKLF 221 thale cress
Q8VC26   196 L------------ALVLLCVAGLVTVGSISISTGIRILTKDIL 226 house mouse
Q9LYA1   522 AHGv---IPNWLWISWAIVVGIAITVSILWIWNLWIELFSERK 561 thale cress
Q9LK26   202 ADDv---IPRWVWVSWTVVIVTAVTVSILWIWNLWVLFFQERY 241 thale cress
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