Conserved Protein Domain Family
HEPN_DZIP3

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pfam18738: HEPN_DZIP3 
DZIP3/ hRUL138-like HEPN
DZIP3/ hRUL138-like HEPN nuclease. Fusion to TPR, Zn-ribbon, RING, Ankyrin, CARD, NACHT ATPase, DEATH and LRR in various animal lineages.
Statistics
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PSSM-Id: 436703
Aligned: 70 rows
Threshold Bit Score: 102.31
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013408071   32 GKTLGEL--FAANRTL--LDDL-YrglhghRKL--LYESQYKKIFPPSNQdpELKEFDITLLFLLTRQLHpqGPSIPpPK 104 
PFX13798       54 WSTLKHA--LANNRPK--LEGLkW------KRI--ITDEKWEKLFPSSGNppDPKEFDITLLHLLLREVC--HLKTP-ST 118 
XP_022810165   54 ESTLQHT--LKNNRPK--LEQLk------rKRV--IFDTQWENLFPSSGKppNSKEFDITLLHVLLREMV--HLKAP-SN 118 
PFX14410       40 PDKLQVS--LNKNKAK--LERLr------pKGV--IFGKQWEMLFSDSGHppASETFDITLLHLLLREIC--HLTAP-ST 104 
PFX14412       50 PDKLQVV--LNNNKAK--LQKLr------rKGV--IFKKQWEMLFPTSGDppDSEKFDITLIHLLLREIC--HLAAP-ST 114 
PFX14406       40 PSTLQIM--LNNNKVA--LANL--------KRRhkLYDNQWEKLFPLSGDppDSNTFDITLLHLLLRNICp-ALTKP-AK 105 
PFX27910      159 QSTIQKIpvLALVHNV--------------Q----PEPKSRDSSGSSVGDppDSNTFDITLLHLLLRKVCp-ALTEP-AT 218 
PFX14411       40 PSTLQIM--LNNNMATlvNLQR--------RRI--LNDNQWEKLFPPSGDppDSNAFDITLLHLLLRKICp-ALIEP-AT 105 
PFX11526     1010 LSTLQIM--INKSKAT--LANLr------sRRK--LYDSQWEKLFPPSGDppDSNTFDITLLHLLLREICt-VLIEP-AT 1075
PFX14414      155 TRDVGEIshKNNKRTLddLKNK--------KRV--LNGNQWEKLFPPSGDppDSKTFDIILLHLLLRNICp-ALKKP-ST 222  Stylophora pi...
XP_013408071  105 nnVWNDPndQwHSQHnvPTKTQAIILIKYERNKLAHRTTTDMEETDFECLWNRLSSAIVEVGGM-SQ----EEVTELHDK 179 
PFX13798      119 --GWHKM--P-ADAD--ASPEASIVRIKCHRKKLCHSDSTGVPNDEFDDKWKKISSSLEVLEVAaHR----KKLQFLKSA 187 
XP_022810165  119 --GWHKM--P-SDSD--ESPEASIVRIKCYRNELCHSVSTVVPNDEFEVKWNMISLSLEVLEVAaYR----KKLQSLKSA 187 
PFX14410      105 --GWHNM--P-ADED--DSLEANLVRIKCFRNELCHSASTEIANADLEDKWNKIASSLEALEMSvQRrkhvEKIEALKND 177 
PFX14412      115 --GWHIM--P-ADDD--SSPEANITRIKCFRNELlHVVSTGIPNNEFEIKWSKISSAIESLEISiQR----NKIQTLKTN 183 
PFX14406      106 --GWDEM--P-ADTD--HSCQAEITRIKYFRNELCHSNSTSVPNVEFEDKWNTVSQSLVALGLD--Q----LEIDSLKTQ 172 
PFX27910      219 --GWNEM--P-ADAD--HSREAEIARIKYFRNRLCHSISTGVPNDEFEDKWNTISPSLVALGVD--Q----LEINCLKTQ 285 
PFX14411      106 --GWNEM--P-ADTD--HSQEAEIVRIKCFRNSLCHSISTGVPNDEFEGKWNTISHSLVALGLH--Q----LEIDCLKTQ 172 
PFX11526     1076 --GWHDM--P-AETD--HSREAEIVRIKCFRNSLCFSISTGAPNDEFEDKWNTISFSLVTLGID--R----LEIVRLKTE 1142
PFX14414      223 --GWHEM--P-ADTD--HSREAEIVRIKYFRNSVSHNFSTGVPNDEFEDKWNTISHSLVALGVD--Q----LEINCLKTQ 289  Stylophora pi...
XP_013408071  180 AIEPEREAIY 189 
PFX13798      188 IIDHKARLLE 197 
XP_022810165  188 TIDHDARLVE 197 
PFX14410      178 PIDHDVRRRL 187 
PFX14412      184 PIDHETQQYL 193 
PFX14406      173 DIDYDTQRRI 182 
PFX27910      286 DIDHGTQRRI 295 
PFX14411      173 DIDHGTQRRI 182 
PFX11526     1143 NVDYGTQRRV 1152
PFX14414      290 DIDHGTQRRI 299  Stylophora pistillata
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