5YUD


Conserved Protein Domain Family
NLRC4_HD
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pfam17889: NLRC4_HD 
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NLRC4 helical domain
This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).
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Statistics
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PSSM-Id: 436120
Aligned: 22 rows
Threshold Bit Score: 108.524
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5YUD_A        767 EDQDLGLYYLRQIDSPLKAINSFNIFLYYvSSHSSSKAAPTVVSHLLQLVDEkESLENMS---------ENEDYMKLHPQ 837  house mouse
XP_015219365  765 AEREKSQNDLKRIDSVAKFVY-FKLFLLF-TCTMSQTAATVIVDFVLNKLNRnTDS-------------RADEVINKYPE 829 
F1M649        465 EEVSKGNSYLKKMVSISDITSLYGNLLLY-TCGSSTEATRAIMRHLAMVCEH-GSLQGLSvtkrplwrqESIQNLRNTTE 542  Norway rat
XP_003908534  465 EEVTKGNGYLQKMVSISDITSTYSSLLRY-TCGSSVEATRAVMKHLAAVYQH-GCLLGLSitkrplwrqESLQSVKNTTE 542 
XP_005600137  465 EEVTKGNSHLQKMAFISDITSKYSNLLLY-TCGSSAEATRTVLRHLAAVCQH-GSLHGLSitkrplwrqESKENVKNTTV 542 
XP_014349006  890 EDTEKGLYYLQQINTFLKVRGRYYFFLRY-ACHSSSKATSRIIQHLLNIFNSsGFLDSQS---------ESSEYLTHHPE 959 
KFR06549      535 EKLERGLQYLQQINTFRKVAGRYNFLLAY-TCSFSSKAVPQIISYLFKLIDCkESLESQS---------EDDEHLQHHSD 604 
XP_008101181  768 EDVDRGLQYLQQINTFVKISGRYQYILRY-ACVEASKAVPQIVTHLLSLPSCeKSFESQI---------KNDLYLQQTPE 837 
XP_013011477  465 EEVAKGNAYLQKMVCISDITSLYSNLLLY-TCGSSAAATRAVLRHLTGVCQH-GSLDGLSvtrrplwrqASIQSMNNTTD 542 
EHB15041      748 EDQDLGLYYLKQINSPMLAVSSYYNFLKYvCSYSSTKVGPNIVSHLLHLADSkESLEYLP---------RNGDSLKHEEE 818 

5YUD_A        838 TFLWFQ-FVRGLWLVSPEsSSSFVSEHLLRLALIFAY 873  house mouse
XP_015219365  830 TTDMNNhIIQFLYEF-PEcRDSSVDTYLLNEVLDVLY 865 
F1M649        543 QDVLKAiNVNSFVECGINlFSESISKSELSQEFEAFF 579  Norway rat
XP_003908534  543 QEILKAiNINSFVECGIHlYHESTSKSALSQEFEAFF 579 
XP_005600137  543 QETLKAiNINSFTECGINlFHESRFESALSEEFEAFF 579 
XP_014349006  960 LAFVEHvFISLLRFQSPAeFLHTVISFMLEFVIMAAY 996 
KFR06549      605 LPIRML-FIDQLSSINPKlLLPVFMQYLLGFATSVAY 640 
XP_008101181  838 LKLRQQeLLSVTLTLFPEvYLSTFSDFVLELVTELAY 874 
XP_013011477  543 QEILKAiNINSFAECGINlFQESVSKSTLSHEFETFF 579 
EHB15041      819 MPLDTQ-AIRLLWQLCPEqCFLLLSEFLLDFALMIAY 854
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