5T4X


Conserved Protein Domain Family
GMP_PDE_delta

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pfam05351: GMP_PDE_delta 
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GMP-PDE, delta subunit
GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.
Statistics
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PSSM-Id: 428436
Aligned: 51 rows
Threshold Bit Score: 147.72
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5T4X_A        30 DILRGFKLNWMNLRDAETGKILWQGTEDLSVP-GVEHEARVPKKILKCKAVSRELNFSSAEQMEKFRLEQKVYFKG--QC 106
XP_001303980  15 RILKGFKLISLTLKNSSNGKVAWTSKDWTDDVfSAVKDAHLPKEMLGYPAVGREIVFSTEEAIKEFRIQQDILVHG--QN 92 
XP_002504708  17 KIAAGFTIDGMNMRDASTGEMLWEMNSWPSDWhVAEIQARVPARILQCPVVSRELTFSSVEKVANLRCEHRVYLDGapDP 96 
EEY61295      76 KVCKGLTINHMNMRCADTGRLMWQSEEWGEDIyRVEQKARLPVAILKCSAVSREINFSSVEEITKFRLEQRVFLAG--SC 153
XP_009011300   6 SILQGFKLNWMNLRDADSGKVLWQSTDDLSIPd-IEHEARVPKKILKCRAVSREINFSSIEELTKFRLEQRVLFKD--KC 82 
EFX81991       7 DILSGFRVNWMSLREVDTGKLLWQNSDDLSQPd-VEHEARVPKSILNCRAVSREINFSSIEPLENFRLEQKVLFKG--RA 83 
ETN68155      11 KILNGFQINWMILRDADTGKIIWQENKDFSCPe-VEHEAKVPVKILSLRAVSREINFSTVEAMENFRLDQKVLFKG--RI 87 
BAH71878       7 DILNGFQVNWMNLRDADTGVVLWQGTEDLSLPd-KEHEAKVPKKILKCRAVSREINFSSVEPMEKLRLQQKVLFKG--RC 83 
XP_003385303  12 KILDGFKLNWMNLRDAENGKIMWQSYDNLSVPg-VEHEARVPKKILKCSQVSREINFSSEQELTNLRLQQNIYFKD--KL 88 
XP_018646336  11 SILKGFKLNWMNLRDADSGKILWQSTDDFSIPe-IEHKAHVPRKILKCKSVSREINFSSKEQLENFWLEQEVFLRD--QS 87 
5T4X_A       107 LEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSKVRLFY 169
XP_001303980  93 IEQWNYKFGFVIPGSENSWETIVEAAGEGNMLPAEYLSGNMYILTSFYAGNLFISRSVVRVFY 155
XP_002504708  97 IEVWDFDFGFVMPGSRNTWQTTVEAAGGEKMLSPTEASGRVTVRTKFTDGDATIVESAVRVFY 159
EEY61295     154 IEEWIFNFGYVIPGSTNTWQQTIESAGSENMLNPEVMSGKLTIETAFYDGQLSIAKTVYRIYY 216
XP_009011300  83 IEEWFFDFGFVIPCSTNTWQSIIEAAPEGQMIPASVLSGHVVIETKFFDDQILVSQSRVRIFY 145
EFX81991      84 LEEWTFDFGFVIPNSTNTWQSIIEAAPESQMMPAQILNGNVTIETKFYDDTLLVSTSLVRLFY 146
ETN68155      88 MEEWFFEMGWVSPNTTNTWQSTIEAAPESQMMPAKVLNGNVTIETSFYDGETLISKSVVRLYY 150
BAH71878      84 LEEWYFEFGFVIPNSTNTWQSLIEAAPESQMMPANVLNGNIVIETNFYDDDLLISSSKVRLYY 146
XP_003385303  89 IEEWSFEFGFVIPSSTNTWQSIIEAAPESQMIPASLLSGNVVIETEFFDGNLLISTSRVRLHY 151
XP_018646336  88 IENWSFEFGFVIPGSTNTWQSLIQSDSADRMIPAKVLSGNVVIVTHFYDGDLLVSKSKVRIFY 150
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