Conserved Protein Domain Family
Gb3_synth
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pfam04572: Gb3_synth 
Alpha 1,4-glycosyltransferase conserved region
The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.
Links
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Statistics
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PSSM-Id: 428017
Aligned: 101 rows
Threshold Bit Score: 76.9008
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFX82279            187 HADLGSPLMALSVQDFAANYSAGLWTHNGPLLLLRVLRRWCNVDDLQSMD--YIRCQG-FHVLPSSSFCPVHYTQLGRLF 263
WGS:AANI:GJ10928-PA 265 PNGFGHQLGELFLQDFHVNYNGDAWAHNGPMGLVRVMSEICGTNNVTLMVnnRQRCQG-FKVFDVNAFYEVPWPQWPLFF 343
XP_002002522        232 AEGIGHEVADLFLQHYQKYFNGKNYVQNGPALVTAVLLKFCGTSLMEAMEggRKSCKG-FRIFNSTAFYSIHWQEWRHFT 310
XP_002051691        239 PTGKGHEIAELFLRDYEKNYNGKEYVQNGPALVTRVVKKLCGDNIVKLIEegRTSCQG-LKVFNSTAFYPFGWPQWMHFT 317
EDW03732            139 PTGTGHEIAELFLRDFKSNYTGEEYTRNGPQGIRRVVRAICGVEIVKAIEegRKICRG-FQVFNSTAFYALPYQQWRHST 217
EDW03733            220 PNGTGHEIAELFLRDFQINYNGRHYVDNGPALVTRVVTAICGVKLVKAIQedSKTCRG-LKLFNSTAFYAIPWQQWEHLT 298
2_pfamImport          1 AQGKGHEFVKEMLIDLAYNYNGIVWAANGPQLFMRTYRKFCNYSENVLLTpiTSPCG--ISVTSSKLFFPVHFSNWKWFF 78 
XP_001842758        237 ATGYGHRFAESCLNDLAEHFDGQVWAANGPFMVTRNLQKFCNVSEVANMT--RARCGGqLSVHPPDVFYRIRYPRHDWFF 314
Q17JV2              237 ASGYGHEFAESCLNDLALNFDGTQWAANGPFMVTRNLRKFCNVTDVSQMN--RQQCGGqLTVYPPDVFYRIRYPRHDWFF 314 yellow f...
XP_001842760        243 ASGVGHEIAELFLRDAAQTFNGDRWAANGPSLVTRVLQKFCNITEPWYMT--REKCGGqFVVLPPEQFFQVYYPQHSWFF 320

EFX82279            264 DnqqqqqqrrrrrpdnnetstdetimttrpeWLtDQVLGIHTWNKLSynrPIHKNSTQTYNRLARHHCPLTYSLA 338
WGS:AANI:GJ10928-PA 344 Naess----------------------netlARtKNSRMVHIWNHIVtkwPLKTDSKSPYMHWAAQHCPRVVAAT 396
XP_002002522        311 Epryl----------------------eetmARtKDSYMIHMWNKVSsgeRIKVASNTAYVKYAEKHCPRTYAAA 363
XP_002051691        318 Epkyl----------------------ketmTItKDSYLIHLWNKASyrgLIRVGSNTALGIYAKRHCPRVYAAA 370
EDW03732            218 Dpefl----------------------edtmEKtKDSYLIHLWNNLShkkLFKVGSNTAYGKYAEIHCPKSYAAA 270
EDW03733            299 Kpqyl----------------------kdtmEKtKDSYLIHLWNKVSsrgLIKVGSNTAYGKYAEKHCPKSYAAA 351
2_pfamImport         79 Ypykse---------------------tvveLLiKDSVAVHFWNFLSkneIVKIGEHCAYETIAAKHCKNILMNT 132
XP_001842758        315 Ypert----------------------eavmTSiKDDILVHMWNKATsgiQLKVNSTAAYVKLAHEYCPNVIKTC 367
Q17JV2              315 Ypers----------------------evvmNSiKNDVLVHMWNKATsgiQLKITSTAAYIQLAQQFCPNVVMNV 367 yellow fever ...
XP_001842760        321 Eekht----------------------eevmERmKGRILTHVWNRMTsdiKIRKDSKVAYIELAKQYCPNVLKFC 373
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