5JHF


Conserved Protein Domain Family
ATG17_like

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pfam04108: ATG17_like 
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Autophagy protein ATG17-like domain
This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.
Statistics
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PSSM-Id: 427715
Aligned: 119 rows
Threshold Bit Score: 83.206
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5JHF_F        16 FLTGAKLICQeSNDHLTTTKLRIR-EWQKFQSKLHFVLDCIQQQTKFLSEIllregigrnlieEEWSQTVLVRLvn-dMK 93  Lachancea therm...
XP_004204349  20 TLQDAQNTCSkAQQSLQYTSYQLNnKLPEKVQFCTFMVQGIKQQHEIVSSV------------IESLVHRTNGIek-lFE 86 
Q6BSK5        20 TLQEAKKMCTrAQASLQSTTYQLVtQLPERLQFVTFMVDALKQQHELLTSI------------VESQSRIRKESvs-qFN 86  Debaryomyces ha...
A3LX29        20 TLEKAQTLCTnAQTSLHATSYQLTsHLPDLLEEANVLYESLKTQHELLAKI------------SESLRRSIRDQllntLE 87  Scheffersomyces...
EGW34801      18 TLERAQKICTsAQASLHSTQNELSvHLPDIMDAVEFLYDALARQHETVLRI------------TESLKRHVRTKvdsvFE 85 
Q5AI71        25 TLEKTQKICTdAQSSMQKTAQELTiLIPDKLQAIEFLFKSYREQYDSILKQ------------IETTKIYLHTNidkvFN 92  Candida albican...
EER31542      25 TLEKTQKLCTnAQSSLHSTIEELTvRLPGKLEATEFLYNSYIRQHGLINKQ------------IDHIREYVKQKinnvFT 92 
EMG46698      25 TLEKTQEICSnAQSSLQLISQEITiRLPEKLEATEFLYNSYIKQYATVSKQ------------IDMINRNLQKKltdvYF 92 
EDK43330      28 SLQSAQKLCSiAQTQLNETYEDLGvQLPNDLEVVELLFEGYQRQLDMVGQV------------LKRSELLLSRDvdsvLV 95 
CCE40570      22 TLKKAQKLCTaAQLSLEKTRQDLTvQLPIELDSAEHLLESYQSQYELVDKH------------IKNLKRLLAENvdrvFA 89 
5JHF_F        94 -F----WQNEITKMMNKLDNITNEID------------------QQhNSKLGDFISRDSSHILDSKLnei---------p 141 Lachancea therm...
XP_004204349  87 eEyttsLEPAVSQLEQILEKLKETKVpsflvqslnqdeettnseAGhEYSLIDFVPLASITTLKKNAvvyksnssklhks 166
Q6BSK5        87 vQverdLTPALAELDDILARLAKAKVpsylinnvvhelevhidtLVeDRNLCDFISMDDIKLLTTNIeiykanctklhgl 166 Debaryomyces ha...
A3LX29        88 kQqstlLQPALNNLDDIVGHLSATIVpsfl----------iekdEAeNRTLADFISTDSINLLRRNIqiytnnhekirql 157 Scheffersomyces...
EGW34801      86 -EfgsvLDPAVEKLDGIISQLRSTTVplfllr------ekeeeeQEdGKSLADFIAMDSIALLKQNIniyksncgrlrka 158
Q5AI71        93 -DikdlLDPSLARLNNILLELKKTRVpsiv-----------vegTSeGKTLFDFTSIQSINLLKENIgifksncskiknl 160 Candida albican...
EER31542      93 -EindtLEPSFDQLQHILQKLKKIKVppfi-----------vqdGSsNKSLLDFTSLDSMEMLKQNIeiyksncnkirkv 160
EMG46698      93 -DfdsvLNPSLNQLNRIMKELEKTKVpsfi-----------vtdGStNKSLLDFTSIDSINLLKENIeiyksnctkakis 160
EDK43330      96 -EidsdLNPKLNDLSTILKQMENTIVpdfv----------qvngMEgDKRLYDFLAMESTQFIQNNIeiykqnckkasek 164
CCE40570      90 -DiegtLEPSLRQLDTTITKMRSIKVpsfv----------ltseEIaPRTLLDFIATESIDIMKENIniyrtncaklkrl 158
5JHF_F       142 tiRKQVENITRQyqTMlakvqSQLVES--RMKGLRDEFSSkfg-dqcREnlklNEEFTNEADQLEQELADFLKSFTDHFD 218 Lachancea therm...
XP_004204349 167 lrTSLKNLLTDPydDIigkkyNKVLQTynEIIPLQLDLKVsqs-gapYKtsnfLNVIIKENSSLESELVSILEMLTNHYD 245
Q6BSK5       167 leKTMNESVIEPyqIIalkkyHNIMKQykELMPVQLGMNLapd-vspYKlnnlINTILKENSSLEHELVPMLEMMTNHYD 245 Debaryomyces ha...
A3LX29       158 lnNKLQDVILSPfhEIgskkfNKTVKLyeEITPLQLKLKAitsniapLDssnvVATLLKENAALENELVSILEMLTNHYD 237 Scheffersomyces...
EGW34801     159 llGNFEDIL--EynMKmnkqfSQIKKRyeNLVPLKVEIKSi------QSkestIGTVLRENQALENELVSILEMLTNHYD 230
Q5AI71       161 ldLEVKEKLNIEqdRMns-rwNKSVKMydLIAPLQLELRAlih-gasNEsnsfMGTILRENQALENELVSILEMQTNHFD 238 Candida albican...
EER31542     161 vdTEVMEKISNQynSMvs-idKEIRKVydSLTPLKVELRTqsk-gksIEssslVATILRENESLEDELVSILQMQTNHFD 238
EMG46698     161 vdSEIIKI--NElsKSlvtkkTSITKTfdSLTQLKIDLCStpp-eklVEsnsfVGTILRENETLESELVSILQMQTNHFD 237
EDK43330     165 lnLEIQVLRDEQhkLLhy--qGTVQKEyeLLGRLQLELKLaqg--dmIEskgqEGVILKENRALENELVSLLEMMTNHYD 240
CCE40570     159 lsDEFQSGILNPfhLFst-qhGVINTEfdRLGPIQIEYRTahg--niLEskgvMGTTLKENQALENELVSLLQMLTNHYD 235
5JHF_F       219 KCSalSSRSVSPEDaq------nlFEIVERDDKDLAAINSLLQDAAIDVASFVRKVNMLLDERDADKAKMQATLSk---L 289 Lachancea therm...
XP_004204349 246 QCV--HGKLLFANNspsk--ddinFEVLQNDAKELPEVLKELYSVYKIIINNEARAHKYLEGEYRKIDSFVESANdlleY 321
Q6BSK5       246 QCV--QGTLFFNTKnpkdpsgdvnFEVLRNDALELPDVLKELNTVYDIIVNNEVRTKKLLSSEFSRIDSLISMIKdlleF 323 Debaryomyces ha...
A3LX29       238 QCT--QGVQILYSGgsq----qvnLEILKNDAQELPDVLKELHTVYDIIVNNEARAQKFINAHSPSIEVVIATMKdqlsF 311 Scheffersomyces...
EGW34801     231 QCM--KAVELISKGntt----ginLEVLQGDVRELPDVAKELNAVYEIILKNEERSQKYL--HTETIEATITLLQqelqT 302
Q5AI71       239 QCM--KAVELISSGngc----dmnLGVLKNDAQELPEVFKELTTIYDIILRNEERSKKFLATHMPNIEKISDIVKeelaV 312 Candida albican...
EER31542     239 QCM--KAVVLVSSGsksd---ainLEVLQSDAYELPEVFKELTTVYDIILQNEERSKKFITINRSNIDSVSQLINrameM 313
EMG46698     238 QCM--KAVELVSFGngn----dvnLEVLRNDVQELPEVFKELTTVYDIILQNEERYQKFIGPKKSNIESVTTTIKkeldL 311
EDK43330     241 QCK--SAVELLSRGgsteh-tkinLDVLEVDSQELDDVFKELKAVSEITSTNSAKSKRLYKQYNEHIVKCTTYIKeeleK 317
CCE40570     236 QCN--KAVELLSSEssnv---nvnIEVLATDANELSEVFNDLTLVYEIVLTNESKSNKTFQQYRSYIDTCGSLLRteiaN 310
5JHF_F       290 LTELRkHE--EYISVFEGISALIQKF---------KASCLEDIRQTRNLLDFYANFERSYH-NLLKEVKRRKETAAklSQ 357 Lachancea therm...
XP_004204349 322 FVGFKeDNltRFMILSISCDEIFSKCsidv--ppdRTPISAYTDAVNHLSYHYTQFLDVFKtKYLSELFHEQYTYP--KV 397
Q6BSK5       324 YTDYKaTHlsKYMILVLSCDEIFGKCsiam--nsnQTPLEAYIETITSLSYHYTQFLSIYKsEYLTELFYEQYTYP--RK 399 Debaryomyces ha...
A3LX29       312 YRSFKsKNipEIMVLFTVCEEILMKSpiedpggpeQTPIEKFTDTVNQLVYHYTQFLNVFKsQYLRELHHEQFSYP--RK 389 Scheffersomyces...
EGW34801     303 YRTFKtTAlpKFILLLSECENKLqissi---pstaETPTRLYVQILEELTFHYTQFLHIYKtKYLSELYHEQYTYP--RK 377
Q5AI71       313 FRKFKtEEipRYTFLIAECENKLKECsmpv--ksdQSPSQVYTQTLQELTEHYVKFINIYKtKYLAELHHQQFTYP--RK 388 Candida albican...
EER31542     314 FREFKvNSypKYLILIAEIEEKLNTCsids-tdddKSPCEVYSETLQELTSHYVQFINVYKtKYLIELHHEQYTYP--RK 390
EMG46698     312 LRDFKtEMypKMVILIDELAKKLNVCsipi--ipgKSPIETYSETLQELTSHYVQFLNVYKtKYLSELHHEQYTYP--RK 387
EDK43330     318 IRLFKtNKvpQFLSFFQECKNVFSKCsivdeelkdLTPSQVYAETISQLVFHYTKFLDVYKtKYLAELHHEQYSFP--KK 395
CCE40570     311 IREFKvAKlpSFMLLLNESIEVLRTCsitdvtpadSSPCEIYSETIEQLVYHYSQFIDIFEtKYLTELHHEEFIYP--RK 388
5JHF_F       358 ILKSCET----QLEQINTADLRERQMFLLENGNYL 388 Lachancea thermotolerans CBS 6340
XP_004204349 398 FFSKLYEflneDLTQLQQEESTRRSQWIAKYGEFI 432
Q6BSK5       400 YLAKLTDflnnDMFHLQQEEYERRKNWLARYGEFI 434 Debaryomyces hansenii CBS767
A3LX29       390 FLSKLTNflndELYKMQIEEKERRRAWLTKYGDFI 424 Scheffersomyces stipitis CBS 6054
EGW34801     378 FLKKLTEllnqDMYRIQLEETERRKQWTAKYGNFI 412
Q5AI71       389 FLKKLTEflneDIYRIQIEESERRRQWTSRYGEFI 423 Candida albicans SC5314
EER31542     391 FLKRLTEflyeDVYGIQLEEAERRRRWMAKYGQFI 425
EMG46698     388 FLGKLTEflyeDIYGIQFEESERRRKWMSRYGKFI 422
EDK43330     396 FLKRIEDfindEVYRMQSEEINHRKRWLDKYEEFI 430
CCE40570     389 FLKRIDGflneELYRMQLEETNRRRSWLAKYGEFI 423
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