6U19


Conserved Protein Domain Family
PSMD4_RAZUL

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cd22297: PSMD4_RAZUL 
RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins
PSMD4 is also called 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, antisecretory factor 1, AF, ASF, or multiubiquitin chain-binding protein (MCB1). It acts as a ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. It displays a preferred selectivity for longer polyubiquitin chains. PSMD4 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. The proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The model corresponds to the C-terminal Rpn10 AZUL-binding domain (RAZUL) of PSMD4, which is responsible for binding the AZUL domain of E6AP/UBE3A. AZUL stands for amino-terminal zinc-binding domain of ubiquitin E3a ligase.
Statistics
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PSSM-Id: 412092
Aligned: 40 rows
Threshold Bit Score: 52.1889
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
AZUL binding
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:AZUL binding site [polypeptide binding site]
Evidence:
  • Comment:AZUL = amino-terminal zinc-binding domain of ubiquitin E3a ligase
  • Structure:6U19: Homo sapiens hRpn10/S5a RAZUL domain in complex with the AZUL domain of E3 ligase E6AP/UBE3A; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ## # ## #  ##  ## #####   # ##  ##  #  #     
6U19_A        16 AKEEDDYDVMQDPEFLQSVLENLPGVDPnNEAIRNAMGSLASQATKDG 63  human
XP_001749585 350 ATPADQAQVAQDPEFYANLVSGLPGVDInDPAIQEALRSLQSASGGNG 397 Monosiga brevicollis MX1
XP_002901695 298 PPAPASNLPFMDPKFVNSLLSGLPGVDPnDPKIQAAMAQMAKKDEKKD 345 Phytophthora infestans T30-4
XP_002981297 348 GSEGDMNKVLGDPSFMNSILASLPGVDPnDPSVRDVLAALQAEEEEVP 395 Selaginella moellendorffii
XP_004359407 296 PQQQQNSDAFRDQEFLNSTLMSLPGVDPnDERIKNVLENLSKKDENKK 343 Cavenderia fasciculata
XP_004365798 329 SIAPNPATSMMDPSFLNSVLGSLPGVDPsDPRIQSVLGAIATGVPPAK 376 Capsaspora owczarzaki ATCC 30864
XP_004353692 289 AGAAPAGGEVTDPQFLNDVLGSLPGVDLaDPQIQEILASMKAQQEQEK 336 Acanthamoeba castellanii str. Neff
XP_004991052 361 EAAESAMDIFQDPAYLTGLLGELPGVDPsDAQVQEMLASLAGSAQKDD 408 Salpingoeca rosetta
OEU21728     334 VKTEDQKQQFQDPQFVNQLLGSLPGVNPnDPAIQSALQNLNKDDDGKK 381 Fragilariopsis cylindrus CCMP1102
P55034       325 EATGAGNNLLGNQAFISSVLSSLPGVDPnDPAVKELLASLPDESKRTE 372 thale cress

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