Conserved Protein Domain Family
TcpS

pfam17456: TcpS

Toxin-coregulated pilus protein S

The toxin-coregulated pilus (TCP) and cholera toxin (CT) are two main virulence factors produced by V. cholerae, which allows the bacterium to colonize and establish an infection in a host and to cause the physical symptoms of the disease, respectively. Increased expression of the TCP, a type IV pilus expressed by the tcp operon (tcpABQCRDSTEF) located on the Vibrio pathogenicity island (VPI), has been associated with enhanced attachment and is essential for colonization of the intestinal epithelium. This domain of unknown function is found in TcpS proteins in Vibrionaceae such as Vibrio choleae.

Links

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Source:	pfam
Taxonomy:	Vibrionaceae
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl38730

Statistics

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PSSM-Id:	340171
Aligned:	3 rows
Threshold Bit Score:	186.289
Created:	26-Mar-2022
Updated:	17-Oct-2022

Structure

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PubMed References

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Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

EGU34490   1 MIMKNKFiCVSFmLAFStVSLAQDVKFYENNISSIESLKMKLEQLELKKKILDVEIEIKEGSDKLQPTVSKAiSTSSESK 80 
Q5DZ57     1 MKYILIF-CASF-LSMN-NVFADELSVFENNYKNINSLKNKLEQLELKKKIQEVEIKILQNESILNPKVINT-PQIDKPK 76  Aliivibrio fischeri...
P29484     1 MNIKLSFiSIAF-LSLSfNVAANEFEKSQEHYKSVTDLKNKIEILELEKKITELSGEIRNAR---MPKIDKSaPVLS-PQ 75  Vibrio cholerae O1 ...

EGU34490  81 AVVRL--ELLKE-ESFDPKL-VRLMYLVGSGDHVAAILAYKDKTENVMNGRSYKGWRLNIKDRKASLVKGPEVIEL 152
Q5DZ57    77 AVVKV--KFMDEsDVFDPKL-VKLLYLVGNNEEKTAVLSYKNKTQNVKDGGYYYGWRLKINNRNVVISKGSNAVAL 149 Aliivibrio fischeri ES114
P29484    76 PVVKSseELQKSiEHIEEELkVELAYLVNNGQQKKYTFNLNGKLITLVNGDFVNGWKFIEDQNKIQFSKGNKVIDV 151 Vibrio cholerae O1 biov...

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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