Conserved Protein Domain Family
GSH_gloB
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TIGR03413: GSH_gloB 
hydroxyacylglutathione hydrolase
Members of this protein family are hydroxyacylglutathione hydrolase, a detoxification enzyme known as glyoxalase II. It follows lactoylglutathione lyase, or glyoxalase I, and acts to remove the toxic metabolite methylglyoxal and related compounds. This protein belongs to the broader metallo-beta-lactamase family (pfam00753). [Cellular processes, Detoxification]
Links
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Statistics
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PSSM-Id: 274569
Aligned: 60 rows
Threshold Bit Score: 334.504
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_004192690   6 YVPVPAFDDNYIWLVSDGr-QAVAVDPGEAAPVRRHLDARGWRLTAILLTHHHRDHVGGVAELLAGAregeP-IAVFGP- 82  pseudomallei group
WP_011094855   3 LISIPALQDNYIWLLSNKanRCVIVDPGEASPVLNALDQNALLPEAILLTHHHNDHVGGVSEILNHY----PnLPVFGP- 77  Pectobacterium ...
WP_011410342   3 LISIPALADNYIWLLHNDdrRCLVVDPGDATPVLQALADHRLTPVAVLLTHHHQDHVGGVSELLQHF----P-VPVYGP- 76  Sodalis glossin...
WP_001052740   3 LNSIPAFDDNYIWVLNDEagRCLIVDPGDAEPVLNAISANNWQPEAIFLTHHHHDHVGGVKELVEKF----PqIVVYGP- 77  Escherichia coli
WP_011145305   3 LISIPALSDNYIWLLCDEnrHVVIVDPAESQPVLDTLESRGWIPDAILLTHHHHDHVGGVPGIIDRF----PeLLVYGP- 77  Photorhabdus lu...
WP_011520646   3 LIAIPALIDNYIWLLHNKkgECLIVDPGDATPVLHILSNYQLKLTSILLTHHHPDHVKGVKLLSQYF----P-VTIYGP- 76  Candidatus Baum...
WP_009874200   3 LKKISILSDNYVWVLLNTsgSCIIIDPGLSEPIIQEIERKKWRLRAILLTHNHIDHTGGTRKIIEYF----PkISVFGP- 77  Buchnera aphidi...
WP_011124714  10 IHPIPVLMDNIIWIWVKEk-QAIVVDPAISEPVINLLKGNGLSLHSVLQTHHHEDHIGGTQELINVW----PsASVIAA- 83  Prochlorococcus...
WP_011132193   9 IIGIRVLRDNIIWLWKKNr-sAVVIDPALSQPVKEYLKTNNLNLEAILQTHHHSDHIGGTRELIKEW----PnVKVIASc 83  Prochlorococcus...
WP_011130565  17 IHALPVLQDNIIWIWIKGn-QAVVVDPAIAEPVKTWLRTRKLSLAAVLQTHHHADHIGGTLELLRDW----PnAAVVAA- 90  Prochlorococcus...

WP_004192690  83 -AHE--A--IEHITRRVAGGERVRIGApaLEFDVIDVPGHTRGHIAYFQP------AgpgnaAp------hLFCGDTLFS 145 pseudomallei group
WP_011094855  78 -KET--A--KCGATYLVEEGNTVSLLN--SEFSVIEVPGHTSGHIAYYNAp-------------------fLFCGDTLFS 131 Pectobacterium ...
WP_011410342  77 -EET--R--SKGATQIVNEGDSLTLLD--HTFSIMALPGHTLGHIGFYSAp-------------------wLFCGDTVFS 130 Sodalis glossin...
WP_001052740  78 -QET--Q--DKGTTQVVKDGETAFVLG--HEFSVIATPGHTLGHICYFS-------------Kp------yLFCGDTLFS 131 Escherichia coli
WP_011145305  78 -AET--Q--SKGATIIVCGGDSINFGH--FSFQIIDVPGHTLGHIAFY--------Q-----Ap------yLFCGDTLFS 131 Photorhabdus lu...
WP_011520646  77 -QET--F--KQCANIIVKKGDFLVLLE--KKFAVLSFPGHTLGHIGFYSYp-------------------wLFCGDTVFS 130 Candidatus Baum...
WP_009874200  78 -KET--R--QHGVNKIVSHGDRIILLD--KIFYVFFTPGHTSGHVSYYS-------------Qp------yIFCGDTLFS 131 Buchnera aphidi...
WP_011124714  84 -KSDldR--IQFQTKSVVDNEELDILG--QKIKVIEVPGHTSNHICFFLQ------G-----SkeskidpvLFCGDTLFG 147 Prochlorococcus...
WP_011132193  84 kEKD--R--IPFQNSSVKDGDTLELLD--EEVKVIEVIGHTRSHIAFYIN------N-----Nvp-----iLFIGDTLFS 141 Prochlorococcus...
WP_011130565  91 -AED--RdrIPFQTISVRDRDKVSLLN--SSVEVLAVAGHTRAHIAYYLPtnkedlE-----Dp------aVFCGDTLFG 154 Prochlorococcus...

WP_004192690 146 CGCGRLFEGTPAQMLASLDALAALPGDTRVHCAHEYTLSNIQFALACEPGNAALAAWRDEALARRARGEPTLPTTIAHEC 225 pseudomallei group
WP_011094855 132 AGCGRIFEGTPKQMYESIQKIAELPDDTVVCCAHEYTLSNLRFSNDIWPEDPDIESYLHKISQIREKSQSSLPTTLGLER 211 Pectobacterium ...
WP_011410342 131 AGSGRLFEGTPRQMYESFQKVNQLSSATLICAAHEYTLSNLNFAAALLPQDSVITDYQRKIKELRLKNQPSMPTKLHLER 210 Sodalis glossin...
WP_001052740 132 GGCGRLFEGTPSQMYQSIKKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNER 211 Escherichia coli
WP_011145305 132 GGCGRLFEGTAEQMYTSIGKIAELPDDTLICCAHEYTISNMKFAHAVLP-NQTISEYQQKVIRMRENNQPTIPTTLQTEK 210 Photorhabdus lu...
WP_011520646 131 AGCGRIFEGTTKQMYESFQEVNQLSSHTLICCAHEYTLTNLAFASSLLPKDRIISSYQRHVTILRNKKKPSLPTKLSLER 210 Candidatus Baum...
WP_009874200 132 AGCGRVFKNKHLEMYRSIKIISSLPDSTLLCCSHEYTLSNLQFSMFILPNDNFIKLYLKKIEIKLKLGQSSLPSYIFFEK 211 Buchnera aphidi...
WP_011124714 148 AGCGRLFEGTPEQMFNSLSRINNLPKNTKIYCAHEYTEANLRWAKSIFPEDIYIEERLKEVILRKSKGFLSIPSKLSEER 227 Prochlorococcus...
WP_011132193 142 AGCGRIFEGTYKQMYYSLKRIKSLPKNTLIYCAHEYTKSNLLWALDLEPENQNIKNKLIEVEKKIALKELTIPCLLEEEM 221 Prochlorococcus...
WP_011130565 155 AGCGRLFEGTAEDMFKALQRLSCLPAKTRVYCAHEYTEANLRWASALHPEDVAISERLADVSSRRQRGALSLPSSISEEQ 234 Prochlorococcus...

WP_004192690 226 AVNPFLRADSASIRatleARL--HE--A--APDR--LAAFTLMREWKNRF 267 pseudomallei group
WP_011094855 212 RINLFLRCHEIDLK----RKIsnEP--E--NIEN--WQVFKMLRSKKDCF 251 Pectobacterium atrosepticum
WP_011410342 211 QINLFLRCHDVNLQ----NKL--NVhpA--PSEE--WRVFAALREKKDHF 250 Sodalis glossinidius
WP_001052740 212 QINVFLRTEDIDLI----NVI--NE--EtlLKQP--EERFAWLRSKKDRF 251 Escherichia coli
WP_011145305 211 KINIFLKCDDIDLQ----RNI--GI--T--PNSQplSAVFHQLRRQKDQF 250 Photorhabdus luminescens
WP_011520646 211 LINPFFRCHDINLH----QAI--NF--SplLGCE--WLVFDYLRQKRDNF 250 Candidatus Baumannia cicadellinicola
WP_009874200 212 KINLFLRTNDNYVK----KSI--GLk-S--TCTD--FEVFKRLRLKKDFW 250 Buchnera aphidicola
WP_011124714 228 KTNLFIRASNQRE--------------------------FAQLRLHKDNW 251 Prochlorococcus marinus
WP_011132193 222 KINLFLRADN--------------------------LKGFSFLRANKDSW 245 Prochlorococcus marinus
WP_011130565 235 RTNLFVRAQSSKE--------------------------LAELRHHKDQW 258 Prochlorococcus marinus
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