Conserved Protein Domain Family
aspS

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PRK00476: aspS 
aspartyl-tRNA synthetase; Validated
Statistics
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PSSM-Id: 234775
Aligned: 969 rows
Threshold Bit Score: 709.913
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
170746938  13 HRYRSHTCGALRPSDVGQSVRLSGWCHRIRDHG-GVLFVDLRDHYGLTQCVI---------------DS-D-SPAFKAAE 74 
108761988   8 EVKRTHTCGQLTATNVGEEVVLFGWVHNRRDHG-GAVFIDLRDRDGLTQVVF---------------EPd-hAEAHALAG 70 
225873931   7 TKQRTHTCGELRAAHAGETITIMGWVNRRRDHG-NLIFLDLRDRYGITQVVL---------------DKdLsAEAHAKAE 70 
162456552   7 ELKRTHRCGDLREADIGKEVVLFGWVARRRDHG-GCIFIDLRDRTGVTQIVFdrsyleaikkhglkvEEkDlVDAHAAAE 85 
256371344  10 AGLRTHYIGALDESLLDRDVSVCGWVARIREHGeHLVFVDVRDHTGTVQCVM---------------DG---------RG 65 
153004196  19 ELKRTHTCGELTKADVGKDVVLFGWVNNRRDHG-GAVFIDLRDRTGVTQVVF---------------EAdVrPEVHDLAG 82 
197121726   7 ELKRTHSCGELTKADIGKEVVLFGWVNNRRDHG-GAVFIDLRDRAGLTQVVF---------------EEdVrPDVHELAG 70 
86158955    7 ELKRTHSCGELTKADIGKEVVLFGWVNNRRDHG-GAVFIDLRDRAGLTQVVF---------------EEdVrPDVHELAG 70 
220916524   7 ELKRTHSCGELTKADIGKEVVLFGWVNNRRDHG-GAVFIDLRDRAGLTQVVF---------------EEdVrPDVHELAG 70 
94968233    9 ELKRTHKCGELRAADANKNVVLMGWVNRRRDLG-GLIFIDLRDRTGITQIVF---------------DNs-nSELQAKAG 71 
170746938  75 TVRSEWVVRIDGRVRTRPAGTENAELPTGAVEVYIDDLEVLGPAGeLPLPVf-gDLE--YPEETRLRYRFLDLRREKLHA 151
108761988  71 SLRLEYCVGVRGKVVSRG-KNVNPKMKTGEIEVRASDLTIFNRSEpTPFPVedsI-D--TSEEKRLAHRFLDLRRAPLQH 146
225873931  71 QARPEYVICATGKVRARSQEAINPKMPTGEIEIAATELLILNDSKvPPFSPa-eEAI--ANEEVRLKYRYLDLRRPEMQH 147
162456552  86 RARSEWVIGVRGVVVSRE-GNVNDKIDTGAIEVWVAEATIFNRAEtPPFEIadeI-E--TREEIRLQHRYLDLRRAPLQR 161
256371344  66 SLHTEAAVRIEGQVARRPEGTENTDLATGAIELRVQHAEVLGDADpLPLPL---DEHaeVEETTRLRWRYLDLRRARMQR 142
153004196  83 QLRLEYCVGLRGKVVSRG-ANANPKLRTGDIEVHATELELFNRSEpTPFQIedkL-D--TSEEKRLQYRYLDLRRAPLQK 158
197121726  71 QLRLEYCVGVRGKVVSRG-GNVNPKLRTGEIEVHASDLEIFNRSEpAPFQIedeI-D--TGEEKRLQYRYLDLRRAPLQR 146
86158955   71 QLRLEYCVGVRGKVVSRG-GNVNPKLPTGEIEVHASDLEIFNRSEpAPFQIedkI-D--TGEEKRLQYRYLDLRRAPLQQ 146
220916524  71 QLRLEYCVGVRGKVVSRG-GNVNPKLRTGEIEVHASDLEIFNRSEpAPFQIedeI-D--TGEEKRLQYRYLDLRRAPLQR 146
94968233   72 DLRSEYCIAVIGTVAKREANTVNKNLPTGEIEVVAKEMRLFNDSKvLPFSIa-dNSN--VNEEVRLKYRYLDLRRPEMQA 148
170746938 152 NIMKRGAIIDSLRRRMREGGFFEFQTPILTASSPEGARDYLVPSRVHPGKFYALPQAPQQFKQLTMIAGFDRYFQIAPCF 231
108761988 147 SLMTRSKMNALTRSYMVGNGFLELETPFMGKYTPGGARNFLVPSRLNAGKFYALAESPQLYKQLFMVAGFDRYFQIVKCF 226
225873931 148 NFEVRHKVALAVRQYLSGQGFFEVETPFMTRSTPEGARDYLVPSRVHPGEFYALPQSPQLFKQILMISGMDRYFQIARCF 227
162456552 162 ALRMRHEINRATRNYLSDKGCLELETPFLVKYTPGGARNFLVPSRISAGKFYALAESPQLYKQLFMVAGFDRYFQIVKCF 241
256371344 143 NLRARAATNAAIRRAMEAQGFVEVETPLLWTPTPEGAREFLVPSRTQPGSVYSLPQSPQIAKQLLMIGGVDRYYQIARCL 222
153004196 159 TLMTRARVNHLTRNYFTDLAFLELETPFMVKYTPGGARNFLVPSRLNPGKFYALAESPQLFKQLYMMAGFDRYFQIVRCF 238
197121726 147 TLMTRAKVNHLTRNYFTDGGFLELETPFMVKYTPGGARNFLVPSRLNPGKFYALAESPQLFKQLYMMAGFDRYFQIVRCF 226
86158955  147 TLMTRAKVNHLTRNYFTDKGFLELETPFMVKYTPGGARNFLVPSRLNPGKFYALAESPQLFKQLYMMAGFDRYFQIVRCF 226
220916524 147 TLMTRAKVNHLTRNYFTDKGFLELETPFMVKYTPGGARNFLVPSRLNPGKFYALAESPQLFKQLYMMAGFDRYFQIVRCF 226
94968233  149 NVQMRHDVTFAIRNYLASQNFLEVETPIMTRSTPEGARDYLVPSRVHPGEFYALPQSPQIFKQILMISNCERYFQIARCF 228
170746938 232 RDEDARADRSPgEFYQLDIEMSFVTQEDVFQAVEPVLRGVFEEFAeGK-RVTK-----EFPRITYADSMLKYGVDKPDLR 305
108761988 227 RDEDLRVDRQP-EFTQIDVEMSFVTQDDIFTMIEGLLKKLWGEVL-GI-DIPT-----PFMRMDFYESMAKYGNDKPDLR 298
225873931 228 RDEDLRADRQP-EFTQIDLEMTFPQQETIFGVVEGFLAAAFEAVG-QQ--ITV-----PFPRMTYDKAIELYGIDKPDLR 298
162456552 242 RDEDLRIDRQP-EFTQIDVELSFVNQDDVFGLMEGLVFAVFKAAL-GK-DLTElyptgRFPRMPYAESMRRFGNDKPDLR 318
256371344 223 RDEDLRADRQF-EFTQLDLEASFVTQEDVRSFVSAAIREVIRSVR-GVdDVP-------IGTITWHEAMTRWGSDKPDRR 293
153004196 239 RDEDLRLDRQP-EFTQIDVEMSFVEQNDVFDVIEGLVVRLWKEVL-GV-ELPR-----PFPRMPFDESMAKYGNDKPDLR 310
197121726 227 RDEDLRLDRQP-EFTQIDVEMSFVEQNDVFDVMEGLVVKLWKEVL-GI-EIPR-----PFQRMPFEESMAKYGNDKPDLR 298
86158955  227 RDEDLRLDRQP-EFTQIDVEMSFVEQNDVFDVMEGLVVKLWKEVL-GI-EIPR-----PFQRMPFEESMAKYGNDKPDLR 298
220916524 227 RDEDLRLDRQP-EFTQIDVEMSFVEQNDVFDVMEGLVVKLWKEVL-GI-EIPR-----PFQRMPFEESMAKYGNDKPDLR 298
94968233  229 RDEDLRADRQP-EFTQIDLEMTFPTQDDVFGVVEGFLTAAWAAAG-HK--LEG-----KFPRMSYDDAIRQYGIDKPDLR 299
170746938 306 NPLIIADVTDLFARE----DvaFKAFKGVIaS-----------GGVVRAIPATGAAAQs-RSFFDKLNDWARSE-GAPGL 368
108761988 299 FGLEHVVLTDLIREHgeggG--VPMIWEAVqN-----------KGIVKAMVVPAEK-AmsRAESDKLEEFAKQA-GAKGL 363
225873931 299 LP-PMTDVRSVFSDE----E--LQSLKIEP-------------GMPIVAIVIPNKSAm-sNTQKKAFGKEVE---EQVGA 354
162456552 319 FGIEHTDLTDLIVEHng-gG--VPFWVELAeKfksgklrrdlpAEIVKGLVIPASA-NlsRQQTEDLERGLRDVkGFRGL 394
256371344 294 FGMELVDVTEAVRDS----G--ARAL---A-------------ADYVTALVVAEPl---sRSRLDELTQRARSA-GAKGL 347
153004196 311 FDMPHVVLTELVRQHdg-gG--LPLLEEAVkA-----------KGIVKAMRVPASA-NlsRTEIDKLEEYVKGM-GAKGL 374
197121726 299 FDMPHVVLTDLVRQHdg-gG--VPLMHEAVkG-----------KGIVKAMRVPASA-NfsRTEIDKLEEYVKGM-GAKGL 362
86158955  299 FDMPHVVLTDLVRQHdg-gG--VPLMHEAVkA-----------KGIVKAMRVPASA-NfsRTEIDKLEEYVKGM-GAKGL 362
220916524 299 FDMPHVVLTDLVRQHdg-gG--VPLMHEAVkA-----------KGIVKAMRVPASA-NfsRTEIDKLEEYVKGM-GAKGL 362
94968233  300 LP-AMNDVKSAFAAE----N--LQTLGIDL-------------DLPVVCVRVPKIGEl-sRKERDDLKPMLN---AKSGA 355
170746938 369 GYVVFEeengqltG-----KGPIAKFIPAEVQALIAERAGAKAGDAVFFSA------------G-AEG-KAAGLAGKARI 429
108761988 364 ARAKVA-------DggewtQSPLSKTISPALRQAINQAVGAKTGDLLLFQF------------G-KEA-LVHTVMANLRV 422
225873931 355 ELAYLDverlr----tspqFALLADRI-DAAAAAHCKLERVEPDHRLVVISprlg----aaavSrDTSw-VYKRAGQLRL 424
162456552 395 ARAKLA-------EdgswtQSPLTKSITPELRQKLNEALGAKPGDVLCFQF------------G-KEA-VVHTVMAKLRI 453
256371344 348 AWFRVEsrt--plEi----ASPLAKAMTPAALEALVERTGAEVGDTILVVA------------D-RFE-VACTALGTIRL 407
153004196 375 ARAKIG-------DggewtQSPFAKTVTPALREAVNAACGAQPGDLLLFQF------------G-KES-VVHTVMANLRV 433
197121726 363 ARAKVG-------EggewtQSPLAKTITPALRQAINEACEAKPGDLLLFQF------------G-KDS-VVHTVMANLRV 421
86158955  363 ARAKVG-------EggewtQSPLAKTITPALRQAINDACEAKAGDLLLFQF------------G-KES-VVHTVMANLRV 421
220916524 363 ARAKVG-------EggewtQSPLAKTITPALRQAINEACEAKPGDLLLFQF------------G-KES-VVHTVMANLRV 421
94968233  356 KLfe--------------dFKRLEKSF-PEAAAKIKEIVKPEESDLLVVVAgaqraekaseivTrNQSyAVYGAAGQVRL 420
170746938 430 RIGDEL-----GLCd----K----D---QYAFCWITDFPMYEWSEEEKRIDFSHNPFSMPNIDreafLAL-----DLdal 488
108761988 423 HVAKKL-----GLIpeygsG----G---QWKFLWVVNPPLFEYDDETNTWAAAHHAFTRPHDEdv-aYLLt----DP--- 482
225873931 425 ELGKRFaaehkAFE-----KkgtaA---DYQFLWVTDFPFFEWDEQSHTWTFAHHPFTSPHQDd---LIAgrlesDQ--- 490
162456552 454 DVAKKM-----GLIpeyghG----D---QWRFLWVTNPPLFEFDEETGRWAAAHHAFTRPIDEhv-aLLEs----DP--- 513
256371344 408 ALGRHL------------------AdpdALDVFWVIDFPLFEGVDDEGHLVSAHHPFTMPHAD----DMDll-erEP--- 461
153004196 434 HLAKRM-----GLIpeygsG----G---QWRFLWVVNPPLFEFDEESGQWAAAHHAFTRPHDt----DVQyl-etDP--- 493
197121726 422 HLAKRM-----GLIpeygsG----G---AWRFLWVVNPPLFEYDEESGQWAAAHHAFTRPHDSdl-qFLEs----DP--- 481
86158955  422 HLAKRM-----GLIpeygsG----G---AWRFLWVVNPPLFEYDEESGQWAAAHHAFTRPHDSdl-qFLEs----DP--- 481
220916524 422 HLAKRM-----GLIpeygsG----G---AWRFLWVVNPPLFEYDEESGQWAAAHHAFTRPHDs----DLQfl-esDP--- 481
94968233  421 AIAQKYsdrhgCFK-----K----G---EFKFLWVTDFPFFEWDENDKRWNAAHHPFTSCHEEdmgk-----lesDP--- 480
170746938 489 ssedengantkriLDIKAFQYDIVCNGVELSSGAIRNHRPDVMEKAFAIAGYGHEVLEQKFGGMLNALRMGAPPHGGIAP 568
108761988 483 -------------GRVKCHRYDVVLNGFEIGGGSIRLHDPKVQAEVFKALGISDEDARAKFGFLLDALKFGAPPHGGIAL 549
225873931 491 -------------AAVRALAYDVVLNGTELGSGSIRIHRQDVQQQIFRALGMSDDEAKERFGFFLEALQYGTPPHGGIAL 557
162456552 514 -------------ARVECYRYDLVLNGFEIGGGSIRLHDPEVQARVFKTLGIDENDARDKFGFLLDALRSGAPPHGGIAL 580
256371344 462 -------------LRVRSQSYDLVMNGWELGSGSIRIHRPDLQAQIFGLLGLDEQAAADRFGFLLDAFRFGPPPHGGFAF 528
153004196 494 -------------GKVNCYRYDLVLNGFEIGGGSIRLHDPAVQARVFKAMGISDEEAKNKFGFLLEALKMGAPPHGGIAL 560
197121726 482 -------------GKVNCYRYDLVLNGFEIGGGSIRLHDPEVQARVFKAMGISDEEARSKFGFLLDALKMGAPPHGGIAL 548
86158955  482 -------------GKVNCYRYDLVLNGFEIGGGSIRLHDPEVQARVFKAMGISDEEARSKFGFLLDALKMGAPPHGGIAL 548
220916524 482 -------------GKVNCYRYDLVLNGFEIGGGSIRLHDPEVQARVFKAMGITDEEARSKFGFLLDALKMGAPPHGGIAL 548
94968233  481 -------------GGVRALAYDVVLNGTELGSGSIRIHRQDIQSIIFKSLGMGPEEQQQRFGFFLEALQYGTPPHGGIAL 547
170746938 569 GVDRIVMLLCNEPNIREVVLFPMNQRAEDLMMGAPSEATPKQLRELHIRLN-----LP--E 622
108761988 550 GMDRLAMLLTGAESLRDVIPFPKSKTGTDLMTGAPGDVDDRQLREIHVRPVpvapkA---- 606
225873931 558 GLDRIVMILAGASSLREVIAFPKTAKAIDLMVDAPTPVSDAQLRELHIRPT-----KQ--- 610
162456552 581 GMDRLAMLLSGAPTLRDVIPFPKTNQGTDQMTGAPVLVDAAQLAELHVKTA-----AA--G 634
256371344 529 GIDRLVALLLGEETIREVIAFPKTQSGQDPMTGAPKPVDDGVLAALGLEAR-----RRelR 584
153004196 561 GMDRLVMLLTGAESLRDVVAWPKTQKGTDLMTGAPGDVDAKQLREVYVKSTyd--pgK--- 616
197121726 549 GMDRLVMLLTGAESLRDVVAWPKTQKGTDLMTGAPGDVDARQLRELYVKSTye---pK--- 603
86158955  549 GMDRLVMLLTGAESLRDVVAWPKTQKGTDLMTGAPGDVDARQLRELYVKSTfe---pK--- 603
220916524 549 GMDRLVMLLTGAESLRDVVAWPKTQKGTDLMTGAPGDVDARQLRELYVKSTye---pK--- 603
94968233  548 GLDRIVMILAGATSLREVITFPKTAAATDLMMDAPTPVSAEQLQQLNIKVT-----KR--E 601
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