6L53


Conserved Protein Domain Family
SMG1_N
?
pfam17229: SMG1_N 
Click on image for an interactive view with Cn3D
Serine/threonine-protein kinase SMG1 N-terminal
This entry represents the N-terminal disordered region of SMG1, which is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family. SMG1 associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. It also plays an important role in genotoxic stress responses to DNA damage.
Links
?
Statistics
?
PSSM-Id: 435799
Aligned: 10 rows
Threshold Bit Score: 166.162
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
6L53_A         32 TDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVvSRQRHDDTRVHADIqNDEKGGYSVNGGSGENTYGRKSLGQELRVN 111 
XP_015215613   27 GDGASASPDGVKRGAPREHGPEAPPDSQPFGAPG-SPPQCDEASAASDG-LEEEGGYEVNGGLGESAFGRKSLGQELRRN 104 
XP_014350631   28 SDSASADQDNLKYSVSRDRGSSASYGLQPSNSTVvSRQRHEGIQVLADAqNEEGGGFDVNGGLGENAYGRKSLGQELRVN 107 
KFO20668        8 TDSASAEPDNLKYSSSRDRGGS-SYGLQPSNSAVvSRQRHDDTRVHADIqNDEKGGYSVNGGSGENTYGRKSLGQELRVN 86  
AAI24614       27 SDSLSASQDGVKCSVSRDRGSEVLFEILPSDRPG-TPPLHNDAFTATDA-LEEGGGYDADGGLSENAYGWKSLGQELRIN 104 
KPP80159       44 GDSVSASQERLKCSASGDHAPGTLVDAAPADSPG-TAPLHNEVFAASDA-LDEGGGYEVDGGACENTFGWKSLGQELRLN 121 
XP_007568375   27 GDGVSSLQDKLK---SRELGSGPSYDVLPPRCPE-QPPLHSDAYGAADA-HQEEAGYEVEPGVCDTAFGWKSLGEELRPN 101 
XP_005462924   27 VNSVSSSQDEVK---SREFGSGPLYDVLASSCPE-QPAVPSNVYAAADA-HQEEGGYEAGQGVCDTTFDWKSLGQELRPD 101 
1_pfamImport    1 VDSVSSSPDGVK---SRELGSAAAYDVLPCSYPE-QPAEPRDAHAPADD-HQEEDGYDVGHGVSDTTFGWKSVGQELRTN 75  
XP_016853791   38 TDNPSTDQENLKYTTSRERSSSSSYGLQPSNSAVvSRHRHDEIRVPTDIqNEEKGGYSVNGGSGENTYGRKSLGQELRIN 117 

6L53_A        112 NVTSpEFTSVQHGSRALATKDMRKSQERS 140 
XP_015215613  105 DVTA-DLTSFQHGNRALATKDMRKSQDRL 132 
XP_014350631  108 NVTL-DSTSVQHGNRALATKDMRKSQERP 135 
KFO20668       87 NVTSpEFTSVQHGSRVLATKDMRKSQERS 115 
AAI24614      105 DVTT-DITTFQHGNRALATKDMRKSQDRP 132 
KPP80159      122 DVTS-DLTSFQHGNRASASKDMRKSQDRP 149 
XP_007568375  102 DVTS-DLTTFQHGNRALASKEMRKSQDRG 129 
XP_005462924  102 DLTT-DLIPFKHGNRALASKDMRKSQDRG 129 
1_pfamImport   76 DVTT-DLTPFQHGNRALASKDMRKLQDRG 103 
XP_016853791  118 NVTNsDFTSAQHGNRALITKDMRKTQERS 146
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap