Conserved Protein Domain Family
Ferlin_C

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pfam16165: Ferlin_C 
Ferlin C-terminus
This domain is found at the C-terminus of proteins belonging to the ferlin family, including dysferlin, myoferlin, otoferlin and fer-1-like proteins.
Statistics
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PSSM-Id: 435183
Aligned: 8 rows
Threshold Bit Score: 152.617
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021335523 1135 PRFSIFRSKRMKGWWPLIK----------------LKSQEDIEREEREAeqek-knkKKKKKKSSKRSQMKPEDLQFVDN 1197
1_pfamImport    1 PRLSIFRAKKMKGWWPLTR----------------PKTAEDFEREEKEReeakkkgnKKKKKKKDKRSNMKKEDIEYSDS 64  
NP_001130028 1834 PRCNLFRCHRLRGWWPVVK----------------MKDMEDVEREAREA--------QAGKKRKRKRRAGRPEDLEFTDT 1889
XP_005986843 1807 PRFSIFRNKRMRGWWPFVK----------------LKSEEDEEKEE-----------KEEKKKKEKKRKGKPEDFEYKDA 1859
XP_015213165  946 TS-SIFKKKREKGWWPFTK----------------VKEAEEEEEEK-----------ENDNKTKKKKKEKERETVTVGTG 997 
2_pfamImport    1 PKVNMFKQRVLKGWWPFIS----------------QKLVKEFHVDFRVG--------SLVNKEKNKPLTKKLAPLMFKPV 56  
CAP33348     1969 DTVNIFEARNLYGWWPMLTdeyphvsceskqlqncIKIQEE----------------PQNAKKKNDDIGKDPKWIM---- 2028
3_pfamImport    1 PRFSIFRSKRMKGWWPLIK----------------LKSQEDIEREEREAeea--rknKKKKKKRSKRGEIKPEDLQFVDA 62  
XP_021335523 1198 SGNTFLLM-GKVEAE---FHLVTPEEAEKNPVGK------ARKEPEP---LDKPNRPKTSFNWFVNPMKTFVFFIWKKYK 1264
1_pfamImport   65 SGSTFLLMlGDILARrnkTLCGSVAEARRSPCGY------IKLQTVS---CPPSSGPSTSFTGFANRRKTFIFLFWRRFK 135 
NP_001130028 1890 GGNVYILT-GKVEAE---FELLTVEEAEKRPVGK------GRKEPEP---LEKPNRPKTSFNWFVNPLKTFIFFIWRRYW 1956
XP_005986843 1860 SGNTYILT-GKVEAE---FQLVTVEEAEKSPVGL------GRKEPEP---LELPNRPKTSFNWFLNPLKTFIYFIWKNYK 1926
XP_015213165  998 SSAYILELtGKVEAE---FELLTSEEAEKHPAGE------GREEPQP---LEKPNRPTVSMSWIVNPFKTLYFFIWRNYK 1065
2_pfamImport   57 SSQLMVLR-GKVEAE---LHLVTEEEADKNPVGL------GRNAPEP---LEKPNRPDMLLSVFYANAKSIACMFWRSYK 123 
CAP33348     2029 ---------GLVEMD---MMLLTKQEADQEPAGK------KRAEPNHspfLEKPNRKTWANSWLVSRIKPCIKYFWHYYG 2090
3_pfamImport   63 SGNTFVLM-VGPEVEsacFAFITRVMAQAGGLGKvldscmGMPAMAQ---VESLGRPKTSFNWFVNPMKTFIFFIWKKYK 138 
XP_021335523 1265 -KYIIALIILVILGLFLGLILYTMPSHISQLI 1295
1_pfamImport  136 -KFIIALVILAILTFFLGLIIYTLPQQISSLI 166 
NP_001130028 1957 -RILVLLLLLALITIFLLLVFYTIPGQISEVI 1987
XP_005986843 1927 -KYIIALLIIAILALFLALILYTLPGEISKQI 1957
XP_015213165 1066 -WYIIFSLLGVSVTSFLVMLVYTFPGNITNKl 1096
2_pfamImport  124 -KYIIIFLICFLLGLFLFLFLFNFPQAISHKM 154 
CAP33348     2091 lQILLWILIIALLALTIFALIQTWPIILVEif 2122
3_pfamImport  139 -KYIIALVVLVILALFLFLILYTLPGQISQLI 169 
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