4DD8,3G5C


Conserved Protein Domain Family
Reprolysin
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pfam01421: Reprolysin 
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Reprolysin (M12B) family zinc metalloprotease
The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.
Links
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Statistics
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PSSM-Id: 426256
Aligned: 17 rows
Threshold Bit Score: 234.117
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4DD8_D         5 RYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDKLYQK-LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQAR 82  human
XP_002823810 241 KYVEMFVVVNNQRFQMWGsNVNETVQRVVDVIALANSFTRG-INTRVVLAGMEIWTEGDLIDVTVDLQITLRNFNHWRQE 319
Q3TTE0       185 RFIMMDIIVDKKLFDYMGsDTEVVLQKVIQIIGFVNTMLSK-LKLTVLINSIEIWSKENRIRLSKAVDDLLVQFSIWKHE 263 house mouse
O77780       178 QYIEMHIVVEKDLYNHMGaDTTVVIQKIFQLTGLTNAIFTS-LNITVILSSLELWIDENKIPVTGDANELLHRFVKWKRS 256 cattle
Q99965       178 KYIEMHVIVEKQLYNHMGsDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHTFLRWKTS 256 human
O75077       299 KYLELMIVNDHKTYKKHRsSHAHTNNFAKSVVNLVDSIYKEqLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR 378 human
3G5C_B         7 KYIELMIVNDHLMFKKHRlSVVHTNTYAKSVVNMADLIYKDqLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRD 86  human
O75078       239 KYVELIVINDHQLFEQMRqSVVLTSNFAKSVVNLADVIYKEqLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRRE 318 human
O15204       218 KYIDLYLVLDNAFYKNYNeNLTLIRSFVFDVMNLLNVIYNT-IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSS 296 human
XP_015000478 199 KYIELFIVADDTVYRRNShPHNKLRNRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELHSNIETTLLRFSSWQER 277

4DD8_D        83 QRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSH-SSGAVNQDHS-KNPVGVACTMAHEMGHNLGMDHDEN---VQGCR 157 human
XP_002823810 320 MLFHRAKHDVAHMIVGHHPGQ-KMGQAFLSGACSSgFAAAVESFHH-EDVLLFAALMVHELGHNLGIQHDHS-----ACF 392
Q3TTE0       264 YRS----QHVAYLLAFEEHPA-STGALYPGNLCKLeYNAAVALYPKgLSLESFSVIVLQLLSIGMGLTYDTE-----NCH 333 house mouse
O77780       257 YLV-LRPHDMAFLLVYREKSN-YIGATFQGRMCDKhYGGGVALHSStISLESLAVIIAQLLSLSMGIPYDDI---NK-CH 330 cattle
Q99965       257 YLV-LRPHDVAFLLVYREKSN-YVGATFQGKMCDAnYAGGVVLHPRtISLESLAVILAQLLSLSMGITYDDI----NKCQ 330 human
O75077       379 -IKQHA--DAVHLISRVTFHYKRSSLSYFGGVCSRtRGVGVNEYG---LPMAVAQVLSQSLAQNLGIQWEPSs-rKPKCD 451 human
3G5C_B        87 FIKEKS--DAVHLFSGSQFESSRSGAAYIGGICSLlKGGGVNEFG---KTDLMAVTLAQSLAHNIGIISDKRklaSGECK 161 human
O75078       319 GLPEPS--DATHLFSGRTFQSTSSGAAYVGGICSLsHGGGVNEYG---NMGAMAVTLAQTLGQNLGMMWNKHrssAGDCK 393 human
O15204       297 NLGKKI-HDHAQLLSGISFNNRRVGLAASNSLCSP-SSVAVIEAKK-KNNVALVGVMSHELGHVLGMPDVPF---NT--K 368 human
XP_015000478 278 ILKTRKDFDHVVLLSGKWIYTHVQGISYPAGMCLPyYSTSIIKDLL-PDTNIIANRMAHQLGHNLGMQHDEF-----PCT 351

4DD8_D       158 CQerfEAGRCIMAGSIGSSFPR-MFSDCSQAYLESFLERPQSVCLANAP 205 human
XP_002823810 393 CK---DKHFCLMHENITKESG---FSNCSSDYFYQFLREHKGACLFNKP 435
Q3TTE0       334 C----TGEVCLMTPKAIYSGGVkDFSTCTLDDFKYLSTRQDLRCLQDLP 378 house mouse
O77780       331 CP----GDVCIMNPAAVHSSGVkLFSNCSVEDFLRFISKPKSQCLQNQP 375 cattle
Q99965       331 C----SGAVCIMNPEAIHFSGVkIFSNCSFEDFAHFISKQKSQCLHNQP 375 human
O75077       452 CTe--SWGGCIMEE-TGVSHSR-KFSKCSILEYRDFLQRGGGACLFNRP 496 human
3G5C_B       162 CEd--TWSGCIMGD-TGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKP 206 human
O75078       394 CPd--IWLGCIMED-TGFYLPR-KFSRCSIDEYNQFLQEGGGSCLFNKP 438 human
O15204       369 C----PSGSCVMNQYLSSKFPK-DFSTSCRAHFERYLLSQKPKCLLQAP 412 human
XP_015000478 352 C----PSGKCVMDS-DGSIPAL-KFSKCSQNQYHQYLKDYKPTCMLNIP 394
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