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PFM_aerolysin-like: pore-forming module of aerolysin-type beta-barrel pore-forming proteins; uncharacterized subgroup
Members of this group belong to the aerolysin family of beta-pore-forming proteins (beta-PFPs). PFPs...
View in Cn3D Specific ProteinProteinSuperfamilySuperfamily MembersPubMed
Generally, pore-forming proteins (PFPs) are secreted as water-soluble monomers, which upon binding t...
PFM_ABFB-like: pore-forming module (PFM) of uncharacterized proteins which have an N-terminal ABFB (alpha-L-arabinofuranosidase B) domain, and similar aerolysin-type beta-barrel pore-forming proteins
Most proteins belonging to this group have a PFM C-terminal to an ABFB domain. Alpha-L-arabinofurano...
PFM_LIN24-like: pore-forming module of Caenorhabditis elegans LIN-24 and similar aerolysin-type beta-barrel pore-forming proteins
The process of cytotoxic cell death occurs in Caenorhabditis elegans containing mutations in either ...
PFM_SP17-like: pore-forming module-like domain of Phlebotomus argentipes 29 kDa salivary protein SP17, and similar aerolysin-type beta-barrel pore-forming proteins
Members include two putative secreted proteins from the salivary glands of Phlebotomus argentipes: 2...
PFM_spherulin-2a-like: pore-forming module of Physarum polycephalum spherulin-2a, Plodia interpunctella follicular epithelium yolk protein subunit YP4, and similar aerolysin-type beta-barrel pore-forming proteins
Spherulin 2a is a coat glycoprotein produced during encystment from the slime mold, Physarum polycep...
PFM_fascin-like: pore-forming module (PFM) of uncharacterized proteins which have N-terminal fascin-like domain, and similar aerolysin-type beta-barrel pore-forming proteins
Most proteins belonging to this group have an N-terminal Fascin-like domains which adopt a beta-tref...
PFM_unzipped-like: pore-forming module (PFM) of proteins having a DUF3421 domain including Drosophila unzipped, honey bee anarchy 1, and similar aerolysin-type beta-barrel pore-forming proteins
Many proteins belonging to this group have N-terminal DUF3421. Drosophila melanogaster unzipped prot...
PFM_crystallin-like: pore-forming module (PFM) of uncharacterized proteins which have N-terminal crystallin domain(s), and similar aerolysin-type beta-barrel pore-forming proteins
Many proteins belonging to this group have N-terminal crystallin (beta/gamma crystallins) domain(s)....
PFM_jacalin-like: pore-forming module of uncharacterized proteins which have an N-terminal jacalin-like lectin domain, and similar aerolysin-type beta-barrel pore-forming proteins
Jacalin-like lectins are sugar-binding protein domains. Proteins having these lectin domains may bin...
PFM_EP37-like: pore-forming module of Cynops pyrrhogaster EP37, and similar aerolysin-type beta-barrel pore-forming proteins
Cynops pyrrhogaster (Japanese newt EP37) EP37 is an epidermis-specific protein which has a non-lens ...
PFM_tachylectin-like: pore-forming module (PFM) of uncharacterized proteins having tachylectin domain(s), and similar aerolysin-type beta-barrel pore-forming proteins
Many proteins belonging to this group have tachylectin domain(s), N-terminal to this PFM; some also ...
PFM_TDP-like: pore-forming module of Flammulina velutipes transepithelial electrical resistance (TEER)-decreasing protein, and similar aerolysin-type beta-barrel pore-forming proteins
Flammulina velutipes TEER-decreasing protein (also known as flammutoxin, FTX), is a pore-forming hem...
PFM_CPE-like: CPE (Clostridium perfringens enterotoxin), HA-70 type C, and similar aerolysin-type beta-barrel pore-forming proteins
This domain is also known as the clenterotox domain (Chlostridium enterotoxin). Clostridium perfring...
PFM_Cry51Aa-like: pore-forming module of Bacillus thuringiensis insecticidal Cry51A toxin, Bacillus thuringiensis cytotoxic parasporin-5 and similar aerolysin-type beta-barrel pore-forming proteins
Bacillus thuringiensis parasporin-5 has strong cytocidal activity against several types of cancer ce...
PFM_lysenin-like: pore-forming module of lysenin and similar aerolysin-type beta-barrel pore-forming proteins
Lysenin (also known as Efl1) is a sphingomyelin-binding defense protein found in the coelomic fluid ...
PFM_alpha-toxin-like: pore-forming module of Clostridium septicum alpha-toxin and similar aerolysin-type beta-barrel pore-forming proteins
Clostridium septicum alpha-toxin is the main virulence factor of this bacterium, known for causing n...
View in Cn3D SuperfamilySuperfamily MembersPubMed
PFM_epsilon-toxin-like: pore-forming module of Clostridium perfringens epsilon-toxin and similar aerolysin-type beta-barrel pore-forming proteins
Clostridium perfringens epsilon-toxin is responsible for fatal enterotoxemia in ungulates. It forms ...
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