Conserved Protein Domain Family
Sporozoite_P67
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pfam05642: Sporozoite_P67 
Sporozoite P67 surface antigen
This family consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. The antigen has been shown to contain five distinct linear peptide sequences recognized by sporozoite-neutralising murine monoclonal antibodies.
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Statistics
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PSSM-Id: 253298
Aligned: 3 rows
Threshold Bit Score: 918.305
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4UCF0   1 MNIIHFLLTIPVIFVSGADKMPAGESSRTSKPSPLVTLESAVTQPSkdP---FKTISALSKATKVWKSAVSVSGDSKTVP 77  Theileria annulata
Q94814   1 MQITQFLLIIPVFFVSAGDKMPTEEQPFPSRLSPLVTLESAITQPT--PvytMRSVGNVAKAAKVWKSAVSSPDVSTTIP 78  Theileria parva
Q9NJQ7   1 MIILHFLLTIQVIFVYGGDNIPAGESPRTSKPSPLVTLESAATQPSkdP---FKTVIALSKATNVWKSAVSLSDDSKTVL 77  Theileria lestoquardi

Q4UCF0  78 TPVSEPMITRSFQEP------------------VSQELEFQSDTEINESGSGSDEDEDDDDD------------------ 121 Theileria annulata
Q94814  79 TPVSEENITSTIHTQtkevpaasgsdsstvtnlVQTQSQVQDNVKQQQDTKGNKTDSEEENEdstvstdvsptiptpvse 158 Theileria parva
Q9NJQ7  78 TPVSEPIITRSFQEP------------------VSQESELELETEMNSGDDGSRSGSEIDDD------------------ 121 Theileria lestoquardi

Q4UCF0 122 -----------------------------EEEEEDDKSTSSKNGKGSPKA-QPGvSSSSTSSASPTSPTTTLSQTGLG-- 169 Theileria annulata
Q94814 159 eiitptlqaqtkeevppadlsdqvpsngsDSEEEDNKSTSSKDEKELKKTlQPG-KTSTGETTSGQDLNSKQQQTGVSdl 237 Theileria parva
Q9NJQ7 122 ----------------------------------DNESTSSKGGKGSQKG-QPAvSPSSGSTTIQTPTSTAVSQSDLG-- 164 Theileria lestoquardi

Q4UCF0 170 PSGSHaqqdpgvgvpgvgvpgvgvpgvgVPGVGVPGVGVPGvggvpgvgvapgvgvpgvGVAPGVGVGadssglpgsggl 249 Theileria annulata
Q94814 238 ASGSH-----------------------SSGLTVPGVGVPG------------------AVSPQGGQS------------ 264 Theileria parva
Q9NJQ7 165 SSGSHdqetaqqdp-----avsqsgvvgVPGLGAGGVGVPGgggagalp---gvgvgraGVLPGVGVGglggv------- 229 Theileria lestoquardi

Q4UCF0 250 gagakagkgqgsglqgpggvgvvpgvgdaasssspgkppgvgagvmpgvgvraqggviigapgvagvpggkpgqpvsqel 329 Theileria annulata
Q94814     --------------------------------------------------------------------------------     Theileria parva
Q9NJQ7     --------------------------------------------------------------------------------     Theileria lestoquardi

Q4UCF0 330 elksdteiNESGSSSEGEDDDDEEEEEENKSTSskgaggkagkgqgsvspgggssasqtsptttpqsglassgshaqqsp 409 Theileria annulata
Q94814 265 --------LASNTSREGQTQHQQARDGDGRVIE----------------------------------------------- 289 Theileria parva
Q9NJQ7 230 ----------pgvgiEGDEVDDAES------------------------------------------------------- 244 Theileria lestoquardi

Q4UCF0 410 qqdpapskpsgggvpgvgvpgvgvPGVGVPGvgvapgvgvvpgvggaTTSSSSTTSTSTSTTTTTTTSSGkPSNQGSHGT 489 Theileria annulata
Q94814 290 ------------------------PKIGLPG----------------STSAPVPTRPPGSSTDTRPASSG-PSAPGGPGS 328 Theileria parva
Q9NJQ7 245 ------------------------PGVGIGGvrv-----------gdAAASTSTTTPSSSTSTTTPSSSS---------- 279 Theileria lestoquardi

Q4UCF0 490 SPRNAVTRQTDSISGPIPSPGDPRAITGQMgllyssksfvGEGERFAVQFLGDFKPKPRRYEGQGTDAVKLKQFIFEEVK 569 Theileria annulata
Q94814 329 SSRSGGTRSTDSVTRPVPSPGAPGIIIREL----------GNRAMDIVQFLGRFKPEPRTYEGDRTNVAELKKFLFEELE 398 Theileria parva
Q9NJQ7 280 ---NAVTRHTDSISGPIPSPGEPRAITGQM----------SEEEQFAAQFLRDFKPKPRRYEGPESETEKLKKFIFEEVK 346 Theileria lestoquardi

Q4UCF0 570 SLVQTLINLKLAIANDFVEISEKLKKKNQNYVPKLKLLKGEQFDTKQKVANVLKGFNSLYFVFFMNLNLAKEVNKPEELA 649 Theileria annulata
Q94814 399 SLVNTLIELKLAIANDFVEITDGLRKNTKDHEARLKLLKGVEFTKRKSVANVVKGFSSLYCVLLMNMNGIKEKKRESEVA 478 Theileria parva
Q9NJQ7 347 SLVETLINIKLAIANDLVEITEKLK--NQNHVPKLKMLKTGQFDTKQKVANVLKGFNSLYFVIFMNLNLAKEVNEPEELA 424 Theileria lestoquardi

Q4UCF0 650 EFLWKLNTIPDKVGREFELAIEKTKGSEKKKELEEAFNSIGLGFKIAQYATNDILSSITNSVYSLIKLKNFGDDFVTEVR 729 Theileria annulata
Q94814 479 DGIWKLSTLPDKVANELLLAMEKIVVPPKTPELEEAFKAIEFGFKIAYYATKDILSSIENTVHNLMHAKNYEENFIAQVR 558 Theileria parva
Q9NJQ7 425 ELLWRLNTIPNKVKKEFELALEKTKASEKKNELQEAFKSIVIGFKIAYYATNDILSSITNSVYYLIKLKNFGDDFVTEVR 504 Theileria lestoquardi

Q4UCF0 730 KSLQMVPHQKNLNGSAFIVKISEIINKKGTEDQDQTSGSGS--------------KGTEGGSLRGQDLTEEEVLKVLDEL 795 Theileria annulata
Q94814 559 NSLRMVPHQMNLTESSFVIKISDMMRRRGTASQDQPAGAGSavtpgrgssgtgraAGTGGGSLRGLDLSEEEVKKILDEI 638 Theileria parva
Q9NJQ7 505 KSMQMVPHEKNLNGSSFIVKISE-MNKKRIEVQDQTSTDES--------------KGTEGGSLRGPDLTEDEVLKVLDEL 569 Theileria lestoquardi

Q4UCF0 796 VKDVSEEHVGIGDLSDPSSRTPNAKPAeLGPSLVIQNVPSDPSKVTPTQPSNlpqvpt-----tgpgngTDGTTTGP--- 867 Theileria annulata
Q94814 639 VKDPSDGELGLGDLSDPSGRSSGRQPS-LGPSLGITDGEAGPTIVSPTGPTI-----------------AAGGEQPPsap 700 Theileria parva
Q9NJQ7 570 VKDVSEEQVGIGDLSDPSSRSPKEKPAkLGPSLVIKNVPSDPPKVTPTQPSNlpqvptsngttngqgngTEGKDQQPasg 649 Theileria lestoquardi

Q4UCF0 868 ------------------------GGNGEGGKDLKEGEKKEGLFQKIKNKLLGSGFEVASIIIPMTTIIFSIVH 917 Theileria annulata
Q94814 701 ----------------------ngTAKGPAGTQPEGGEKKEGLIQKLKKKFLGSGFEVASLMIPMATIIISIVH 752 Theileria parva
Q9NJQ7 650 ngtegkdqqpasgngtegkdqqpaSGNGEGGKDLKEGEKKEGIFQRIKNKILGSGFEVASVIIPMTTIIFSIVH 723 Theileria lestoquardi
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