1AUA,3HY5


Conserved Protein Domain Family
SEC14

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smart00516: SEC14 
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Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.
Statistics
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PSSM-Id: 214706
Aligned: 57 rows
Threshold Bit Score: 66.1689
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1AUA_A         96 EKPLIAKFYPQYYhKTDKDGRPVYFEELGavnLHEMNKVTSEErMLKNLVWEYESVVQyrlpacSRAAGHLVETSCTIMD 175  baker's yeast
O81806         13 LIEKLEIFKIHGR---DKRGRKILRIIGK---FFPARFLSLDV-LKKYLEEKIFPRLG------R-KPFAVLYVHTGVQR 78   thale cress
XP_858024     333 DIASLKALYQTG---VDNCGRTVMVVVGR---NIPVTLIDMDK-ALLYFIHVMDHIAV---------KEYVLVYFHTLT- 395  dog
NP_079255      43 qLKKRFAYLSGGR-GQD--GSPVITFPDY-----PAFSEIPDK-EFQNVMTYLTSIPS------LQDAGI---GFILVID 104  human
AAB66366       40 iLKEKVAFVSGGR---DKRGGPILTFPAR-----TNHDRIRQE-DLRKLVTNLASVPS------E---DVCKRGFTVIID 101  Norway rat
XP_002105001  349 EFKTLKSMNIFYQaGTSKSGYPVFYYIAR---RYKI-GETNGD-LLIYHVILTLKPFC------HSPFEVVIDFTHTCSD 417  Drosophila si...
CAI39715       84 flmqdiAFLSGGR-G--KDNAWIITFP-----ENCNFRCIPEE-VIAKVLTYLTSIAR------QNGSD---SRFTIILD 145  human
AAF25952       12 lLQERVVFLTGGR---DRRGGPLLCFPA-----TPRRDRLKPE-DLRRLLSYLISIPS------DAAK---NLGFTVIID 73   fruit fly
EAW80270     1074 EFKALKTLSIFYQaGTSKAGNPIFYYVAR---RFK-TGQINGD-LLIYHVLLTLKPYY------AKPYEIVVDLTHTG-- 1140 human
NP_566369      48 DLDLLQFFTLQGL---DRSGNRIFRIVGK---YFPARVVSAER-LKKYISQKISNQCP------EGPL-CLVYMHSTVQK 113  thale cress
1AUA_A        176 LKGISISSAysVMSYVREASYISQNYYPERMGKFYIINAPFG-F-S-TAFRLFKPFLDPVTVSKIFILGsSYQKELLKQI 252  baker's yeast
O81806         79 SENFPG------ISALRAIYDAIPVNVRDNLQEVYFLHPGLQsR-L-FLATCGRFLFSGGLYGKLRYISr--VDYLWEHV 148  thale cress
XP_858024     396 ---SEYNHL--DSDFLKKLYDVVDVKYKRNLKAVYFVHPTFR-S-K-VSTWFFTTFSVSGLKDKIHHVDsLHQLFSAISP 467  dog
NP_079255     105 RRRDKWTSV--KASVLRIAAS-----FPANLQLVLVLRPTGF-FqR-TLSDIAFKFNRDDFKMKVPVIMlSSVPDLHGYI 175  human
AAB66366      102 MRGSK-------WDLIKPLLKTLQEAFPAEIHVALIIKPDNF-W-Q----KQKTNFGSSKFIFETSMVS---VEGLTKLV 165  Norway rat
XP_002105001  418 NRF--------RTEFLQKWFYVLPTVAYENVHAVYIYNCNSW-V-R--EYTKFHDRILAPLKGNRKLLFlESPNKLTDFI 485  Drosophila si...
CAI39715      146 RR-----LD--TWSSLKISLQKISASFPGNLHLVLVLRPTSFlQ-R-TFTDIGFWFSQEDFMLKLPVVMlSSVSDLLTYI 216  human
AAF25952       74 MRG---NGN--CSTNAKTILKVLQEHFSANIHNVVIIKPDNF-W-Q----KQRASISSHKYKFETTTVS---IESLNKIV 139  fruit fly
EAW80270     1141 ----PSNRF--KTDFLSKWFVVFPGFAYDNVSAVYIYNCNSW-V-R--EYTKYHERLLTGLKGSKRLVFiDCPGKLAEHI 1210 human
NP_566369     114 DDNSPG------ITILRWIYEDLPSDIKDRLQLVYFIHPGLR-S-RlVIATLGRLLLSGGLYWKIKYVSrL--QYLWEDI 183  thale cress
1AUA_A        253 --PAEN--LPVKFGGKSE 266  baker's yeast
O81806        149 --RRNE--IEMPEFVYDH 162  thale cress
XP_858024     468 --EQID--FPPFVLEYDa 481  dog
NP_079255     176 --DKSQ--LTEDLGGTLD 189  human
AAB66366      166 --DPSQ--LTEEFDGSLD 179  Norway rat
XP_002105001  486 --DAEQqkLPGATLSLDE 501  Drosophila simulans
CAI39715      217 --DDKQ--LTPELGGTLQ 230  human
AAF25952      140 --ESHQ--LTGDFEGQQl 153  fruit fly
EAW80270     1211 ehEQQK--LPaatlalee 1226 human
NP_566369     184 --KKGE--VEIPDFVKNH 197  thale cress
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