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SH2: Src homology 2 (SH2) domain
In general, SH2 domains are involved in signal transduction; they bind pTyr-containing polypeptide l...
View in Cn3D
SH2: SH2 domain
View in Cn3D Specific ProteinProteinSuperfamilySuperfamily Members
SH2: Src homology 2 domains
Src homology 2 domains bind phosphotyrosine-containing polypeptides via 2 surface pockets. Specifici...
View in Cn3D Specific ProteinProteinSuperfamilySuperfamily MembersPubMed
SH2_SH2D7: Src homology 2 domain found in the SH2 domain containing protein 7 (SH2D7)
SH2D7 contains a single SH2 domain. In general SH2 domains are involved in signal transduction. They...
SH2_Src_Frk: Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
Frk is a member of the Src non-receptor type tyrosine kinase family of proteins. The Frk subfamily i...
SH2_SH2D2A_SH2D7: Src homology 2 domain found in the SH2 domain containing protein 2A and 7 (SH2D2A and SH2D7)
SH2D2A and SH7 both contain a single SH2 domain. In general SH2 domains are involved in signal trans...
SH2_N-SH2_PLC_gamma_like: N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
Phospholipase C gamma is a signaling molecule that is recruited to the C-terminal tail of the recept...
SH2_Grb2_like: Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
The adaptor proteins here include homologs Grb2 in humans, Sex muscle abnormal protein 5 (Sem-5) in ...
SH2_Src_family: Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
The Src family kinases are nonreceptor tyrosine kinases that have been implicated in pathways regula...
SH2_CIS: Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The...
SH2_STAT5a: Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins
STAT5 is a member of the STAT family of transcription factors. Two highly related proteins, STAT5a ...
SH2_STAT5b: Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
SH2_Src_Fyn_isoform_b_like: Src homology 2 (SH2) domain found in Fyn isoform b like proteins
Fyn is a member of the Src non-receptor type tyrosine kinase family of proteins. This cd contains th...
View in Cn3D SuperfamilySuperfamily MembersPubMed
SH2_Src_Fyn_isoform_a_like: Src homology 2 (SH2) domain found in Fyn isoform a like proteins
SH2_SH2D2A: Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
SH2D2A contains a single SH2 domain. In general SH2 domains are involved in signal transduction. Th...
SH2_Grb10: Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
The Grb family binds to the epidermal growth factor receptor (EGFR, erbB1) via their SH2 domains. Gr...
SH2_Grb14: Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
SH2_Grb7: Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 7 (Grb7) proteins
SH2_SH2B3: Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
SH2B3 (Lnk), like other members of the SH2B adapter protein family, contains a pleckstrin homology d...
SH2_SH2B2: Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
SH2B2 (APS), like other members of the SH2B adapter protein family, contains a pleckstrin homology d...
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