Conserved Protein Domain Family
MTHFR_2
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pfam19345: MTHFR_2 
Mycobacterial methylenetetrahydrofolate reductase
This family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from mycobacteria. The structure for this domain is known to be a TIM barrel. Both MTHFR1 and MTHFR2 found in Mycobacterium smegmatis are involved in de novo methionine biosynthesis and required for antifolate resistance in mycobacteria. Both of these MTHFRs are monomeric and lack flavin coenzymes.
Links
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Statistics
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PSSM-Id: 437177
Aligned: 2 rows
Threshold Bit Score: 617.405
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
PRJNA261003:LJ00_32860   2 TLNTVALELVPSNLDLGTAHALAELQKVRKLAVDAGLDGRIRHIMIPGMIEEDDGRPVEMKPKLDVLDYWELVQRELPDV 81 
tigr:MSMEG_6596          7 PLNTIALELVPPNIERGASYAVEEAHKVLAIAAETGIEGRIRHVMIPGMIDEDDDRPIEMKPKMDVLEYWNIIRPELPGL 86 

PRJNA261003:LJ00_32860  82 RGLCTQVTSFLGERSLRRRLTALIQHGFEGIAFVGVPRTMTDGEGAGVAPTDALSTFSHLVKHRGVILIPTRDDELSRFG 161
tigr:MSMEG_6596         87 RGLCTQVTSFLGEEALRERLTALSGAGFDGISFVGVPRTMKDGEGEGVAPTDALSIYADLVPNRGAILIPTREGEQGRFN 166

PRJNA261003:LJ00_32860 162 FKCKEGATFGMTQLLYSDAIVNFLTEFSRNTDHRPEILLSFGFVPKMESEVGLIDWLIQDPDNGAVATEQQFVRRLAASE 241
tigr:MSMEG_6596        167 FKCDQGATYGMTQLLYSDAIVGFLTEFAKTTEHRPEILLSFGFVPKMEAKVGLINWLIQDPGNPAVAAEQEFVSHLAEQD 246

PRJNA261003:LJ00_32860 242 PAQKRAQMLDLYKRVIDGVIDLGFPVSLHFEAPYGVSAPAFETFAAMLDYWAPDR 296
tigr:MSMEG_6596        247 PAEKRRLMVDLYKRVIDGVGQLGFPLSVHYEVAYGVSRPAFETLAEMLEYWSPDQ 301
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