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P-loop_NTPase: P-loop containing Nucleoside Triphosphate Hydrolases
Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphat...
View in Cn3D
AFD_class_I: Adenylate forming domain, Class I superfamily
This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal p...
RRM_SF: RNA recognition motif (RRM) superfamily
RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant ...
MPP_superfamily: metallophosphatase superfamily, metallophosphatase domain
Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binucl...
HAD_like: Haloacid Dehalogenase-like Hydrolases
The haloacid dehalogenase (HAD) superfamily includes carbon and phosphorus hydrolases such as 2-halo...
Periplasmic_Binding_Protein_Type_2: Type 2 periplasmic binding fold superfamily
This evolutionary model and hierarchy represent the ligand-binding domains found in solute binding p...
RING_Ubox: RING finger (Really Interesting New Gene) domain and U-box domain superfamily
The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc...
DSRM_SF: double-stranded RNA binding motif (DSRM) superfamily
DSRM (also known as dsRBM) is a 65-70 amino acid domain that adopts an alpha-beta-beta-beta-alpha fo...
View in Cn3D ProteinSuperfamily MembersPubMed
Ubl1_cv_Nsp3_N-like: first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins
This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large mult...
DEAD-like_helicase_N: N-terminal helicase domain of the DEAD-box helicase superfamily
The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or ...
KH-I: K homology (KH) RNA-binding domain, type I
KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal p...
RNase_H_like: Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8
Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on am...
PIN_SF: PIN (PilT N terminus) domain: Superfamily
The PIN (PilT N terminus) domain belongs to a large nuclease superfamily, and were originally named ...
ACT: ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
Members of this CD belong to the superfamily of ACT regulatory domains. Pairs of ACT domains are com...
CD_CSD: CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
Members of this group are chromodomains or chromo shadow domains; these are SH3-fold-beta-barrel dom...
PDDEXK_nuclease-like: PDDEXK family nucleases
Superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holl...
HMG-box_SF: high mobility group (HMG)-box domain superfamily
The High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and trans...
AAK
Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutama...
Adenylation_DNA_ligase_like: Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
ATP-dependent polynucleotide ligases catalyze the phosphodiester bond formation of nicked nucleic ac...
UBA_like_SF: UBA domain-like superfamily
The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ub...
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