Alocasia macrorrhizos trypsin/chymotrypsin inhibitor (AMTIN) and similar proteins
AMTIN, also called alocasin, is a multi-functional inhibitor that shows inhibition against proteases, amylases, and subtilisin. It inhibits the proteases, trypsin and chymotrypsin, and alpha-amylase. It also has antifungal activity against midgut proteases of Aedes aegypti. Members of this subfamily contain an STI-like domain with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Jiyao W et al.(2023). "The conserved domain database in 2023.",