3WG6,4H8N,3VXG


Conserved Protein Domain Family
AKR_AKR3C2-3

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cd19120: AKR_AKR3C2-3 
Click on image for an interactive view with Cn3D
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Statistics
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PSSM-Id: 381346
Aligned: 34 rows
Threshold Bit Score: 300.303
Created: 12-Mar-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3WG6: Candida parapsilosis conjugated polyketone reductase (CPR-C1) in complex with cofactor NADPH, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #####                                        #    #                    
3WG6_A     16 GNKIPAVAFGTGTKYfkrgh------------ndldKQLIGTLELALRSGFRHIDGAEIYgTNKEIGIALKNVgl----- 78  Candida parapsilosis
CEH11835   11 GRSVPRLSFGIGTQHy-------------------qSDASSQVSKALSAGFTFLDAAEVYsNTKSMGKAVSEHlssg--v 69  Ceraceosorus bombacis
OLQ05284   53 SLQMPAIGYGVGTAWfnsg-------------gdksKELILSVQAALDTGFRHIDDAEMYrNEVACGQAIREWlsrs--g 117 Symbiodinium micro...
PPR02557   14 GTTIPWIAWGNGTGLt-------------------nKDAAEYGHLALESGIRHIDTAQLYkTEKQTGEAISRSsl----- 69  Gymnopilus dilepis
EGD79803   16 GRLLPRLAFGTGTQWfrtkdgs-------ssresaqVKLSGALHAALDAGFRHIDEAEMYgTEELTGEALEAWmtkh-ph 87  Salpingoeca rosetta
EDQ88977   12 GQTMPVVAFGTGTQWfsndqgv--------snaneeATLADSLHAALDAGVTHIDSAEMYkTEVFSGPAFQDYlkks--s 81  Monosiga brevicoll...
OCF27328   16 GNKVPILAFGTAAPFl-------------------gKDCSNAILQALRAGFWHIDTAQLYgNQEYVGKALSLWeg----- 71  Cryptococcus besti...
CDI56617   12 GHELPRLAFGTGTALy-------------------nSAASKQVTMALNAGFRFVDGAEAYaNEESAGEGIATFlkss--g 70  Melanopsichium pen...
OAJ06766   20 GFDLPVVAYGTGTALy-------------------qRDVSKEVSIAAEAGHRFFDLAEMYkNTQYAGNGLRPHlasadsg 80  Tilletia indica
ORZ33323   15 GRHMPALAFGCGSKWrksstnpgeslgptdddtdvnRDLVDLIKYALGAGIRHLDSAEVYhTELEVGVAVCEFlaen-pn 93  Catenaria anguillu...
Feature 1               #                                                 ##                  
3WG6_A     79 -nRKDVFITDKYnsgnhtydgkhskhqNPYNALKADLEDLg----------LEYVDLYLIHFPYiseks----hgfdlVE 143 Candida parapsilosis
CEH11835   70 asRKDLFLLTKLgsr---------gipDPLGETKKELSDIg---------vSDKLDAVLLHYPPrgkdg-----apsnIE 126 Ceraceosorus bombacis
OLQ05284  118 tkREDLFITNKVye-----------vdRGCGAVCEEMAPLdc--------lFCSPLRFLIHSVCtrdgkp---fktspRE 175 Symbiodinium micro...
PPR02557   70 -kREDVYVTSKLscrgnge--epvpveDVPKAVQESIDRL-----------GFVPDLFLIHNPFvakp-------gelKA 128 Gymnopilus dilepis
EGD79803   88 vkREDLFITSKIwrg----------lpNVRKTVETTLRNLr----------TPYVDLYLVHAPFikqnd----idadlRT 143 Salpingoeca rosetta
EDQ88977   82 kqRSDFFITSKVfvs----------agDVEKAVQTTLDHFg----------TDYLDLYLLHAPFldkag----vtksvAE 137 Monosiga brevicoll...
OCF27328   72 -kREEVYITAKWgldg-------geknDPRKALEETLSKMg----------VEYIDMFLMHSPItisp-------lsiAE 126 Cryptococcus besti...
CDI56617   71 lkRSDIYVLTKVgrd---------gmkDLQSAVKQEMQKLq----------VDYLDSYLLHLPPrgkdg-----lptnVE 126 Melanopsichium pen...
OAJ06766   81 ikRSDLIILTKIgeg----------qpHAYKALQEEVKALnllikdesttpNPVFDVVLSHYPPradkak---grpsnLQ 147 Tilletia indica
ORZ33323   94 vkREDIWITSKLhpg----------lvDVRGTLERAIRRMg----------VGYLDAYLIHSPFidgirhvlgpdlthAD 153 Catenaria anguillu...
Feature 1                        ##                           #                             ##
3WG6_A    144 AWRYLERAKNEGLARNIGVSNFtIENLKSILDAnt------dsIPVVNQIEFSAYlq--dqTPGIVEYSQQQGILIEAYG 215 Candida parapsilosis
CEH11835  127 AWNRLEKVKDAGLVDVIGVSNWtAKDIEELLASkp------khKIEINQVELNPFlyshpdIQALLKLQEREGITTMSYG 200 Ceraceosorus bombacis
OLQ05284  176 AWEQMMALAKTGKVKSIGVSNWrIADLESIKDLe--------iQPSCNQVEAHPFl----qQVGLLQYCRKRDILVSCYG 243 Symbiodinium micro...
PPR02557  129 MWKALEDLKDQGKLKSIGVSNFrPQDLEEILDGak-------yKPVINQLEYHPYll--ahLQPVLDLQAKHGILTASYG 199 Gymnopilus dilepis
EGD79803  144 AWKELEALKEEGLIKDIGVSNFhVVHLKELLSFck-------hAPVVNQIECHPHl----lQPDLMAFCQEQNIVVSSYA 212 Salpingoeca rosetta
EDQ88977  138 VWKAMEALVDAGKIRSIGVSNFaVQHLESLLATar-------iPPAVNQIEVHPQl----yQPELEEYCRSHEIVVTAYS 206 Monosiga brevicoll...
OCF27328  127 AWSIMETLQEEGKCIDIGISNFgATDIRELCKTwk-------vIPAINQIEFSPYnahdplSKACVKACEEHGIAVSGFG 199 Cryptococcus besti...
CDI56617  127 AWKELEKIKAAGLTKSIGVSNWlASDIQQLLDAgl-------sVPDINQIEFHPYcynhheYIQLLALQKKHGIVTMTYS 199 Melanopsichium pen...
OAJ06766  148 VWRELERAVDDGLTRSIGVSNWlAEDIETLYADadaegggikhPIAFNQIEFHPLiasspqYKALLPLCKEKGIKIMTYS 227 Tilletia indica
ORZ33323  154 FWASLHQAQLDGLVREIGVSSFdAPHIDLLFTKdps-----lpMPAFNQIEYHPLl----pQPLLHKHHAKFGIQMSSYS 224 Catenaria anguillu...
Feature 1     ##  ##                                                         #### #  #        
3WG6_A    216 PLGPITqg-----------rpGPLDKVLSKLSEKYKRn------EGQILLRWVLQR---GILPITTTsKEERINDVLEif 275 Candida parapsilosis
CEH11835  201 SLTSQYkdl---------kpdSKFQQTLEGVASKHGVs------PGTALLYWNLQRt--NGIVVTTSgKEERMKQYVEdi 263 Ceraceosorus bombacis
OLQ05284  244 PQLPVTrnf---------iagSPVEAPLLAAAERTGHt------VGQVLLRWAYQT---GRVPLTTSsKPERMKEYLAif 305 Symbiodinium micro...
PPR02557  200 TLSPLLrhr----------tgGPLKPVLERIAERISKatgrkfdANDVLLLWTRAQ---GVVVVTASgNPERIKRLAEia 266 Gymnopilus dilepis
EGD79803  213 PLASFGqr------------hEPTLALVQEIAAKHNLt------PGQVLLQWNLAQ---GTAVITTSsKLDHIKESAGvl 271 Salpingoeca rosetta
EDQ88977  207 SLKPLAskd----------ecKDILKTAEDIAKAHDKt------TAETLLNWNLSR---GLGVVTTSsRPERLAKTLNcl 267 Monosiga brevicoll...
OCF27328  200 CLQPLSlsd----------ppLPLNPILHKLCGEKGSt------PGQVLLRWAQQEm-sGTVVTTTS-QPHRMHEDVEaf 261 Cryptococcus besti...
CDI56617  200 ALAPFYkdal--------pedGPLSKALKEIAAKNHNr-----tEPSVLLRWALQRs-eGIITTTTS-KESRAKEYLDqm 264 Melanopsichium pen...
OAJ06766  228 PLVPLTrnll-------pempKLKEAIDNAVAAKSGRt------QTSVLLKYAHQMtndGIIVTTSS-KPERTAEYLSmf 293 Tilletia indica
ORZ33323  225 PLVPIVphpklgdlvdgteagKHFLHVLDTLAAKLGEgv----tRAMVLLRWNLDM---GHAVVSTSgRKERIDDIVAvg 297 Catenaria anguillu...
Feature 1                                       
3WG6_A    276 -------------dfELDKEDEDQITKVGKEKTL 296 Candida parapsilosis
CEH11835  264 k-----------nikTLSEEDLRSIEDAAAAEGA 286 Ceraceosorus bombacis
OLQ05284  306 -------------gfELTPEEVAAISTAGRRASQ 326 Symbiodinium microadriaticum
PPR02557  267 t-----------lpdLLTQEEIDEITQVGKTRHF 289 Gymnopilus dilepis
EGD79803  272 s------------gaTITQEDVDAITKTAGEHRH 293 Salpingoeca rosetta
EDQ88977  268 -------------sfTLDQKEIEAIAAAGKGVPH 288 Monosiga brevicollis MX1
OCF27328  262 d------------rpLLTDEEMEEIRKVGEGRYY 283 Cryptococcus bestiolae CBS 10118
CDI56617  265 dtn-------ndaqlKLSEDELKQIDHAGKQHGV 291 Melanopsichium pennsylvanicum 4
OAJ06766  294 asektgkegtpgaedLLSQAELDAITEAAGQYRS 327 Tilletia indica
ORZ33323  298 r------------lrPLNKDECDEVCQAAEKVGK 319 Catenaria anguillulae PL171

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