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Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence. Geneva: World Health Organization; 2009.

Cover of Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence

Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence.

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Acknowledgements

These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project.

GUIDELINES DEVELOPMENT GROUP

  • Marina Davoli
    Coordinating Editor
    Cochrane Review Group on Drugs and Alcohol
    Department of Epidemiology
    Osservatorio Epidemiologico Regione Lazio
    Roma
    Italy
  • Michael Farrell
    Reader/Consultant Psychiatrist
    National Addiction Centre
    Institute of Psychiatry and the Maudsley Hospital
    London
    United Kingdom
  • David Fiellin
    Associate Professor of Medicine
    Yale University School of Medicine
    United States of America
  • Li Jianhua
    Deputy Director
    Yunnan Institute for Drug Abuse
    China
  • Ratna Mardiati
    Psychiatrist
    Directorate General for Medical Care
    Jakarta
    Indonesia
  • Richard Mattick
    Director
    National Drug and Alcohol Research Centre
    University of new South Wales
    Sydney
    Australia
  • Elena Medina-Mora
    Director
    Epidemiology and Psychosocial Research
    National Institute of Psychiatry
    Mexico
  • Fred Owiti
    Consultant Psychiatrist
    Arrow Medical Centre
    Nairobi
    Kenya
  • Afarin Rahimi-Movaghar
    Iranian national Center for Addiction Studies
    Tehran University of Medical Sciences
    Tehran
    Iran
  • Rajat Ray
    Chief
    National Drug Dependence Treatment Centre
    All India Institute of Medical Sciences
    New Delhi
    India
  • Anthony J Smith
    Emeritus Professor
    Clinical Pharmacology
    Newcastle Mater Hospital
    Australia
  • Emilis Subata
    Director
    Vilnius Center for Addictive Disorders
    Lithuania
  • Ambros Uchtenhagen
    President
    Research Institute for Public Health and Addiction
    Zurich
    Switzerland

OBSERVERS

Council of Europe

  • Gabrielle Welle-Strand
    Senior Adviser
    Norwegian Directorate for Health and Social Affairs
    Norway

International Narcotics Control Board Secretariat

  • Pavel Pachta
    Chief, narcotics Control and estimates Section
    Vienna
    Austria
  • Carmen Selva-Bartolome
    Chief, Psychotropics Control Section (until September 2007)
    Vienna
    Austria
  • Margarethe Ehrenfeldner
    Chief, Psychotropics Control Section (as of 1 October 2007)
    Vienna
    Austria

UNITED NATIONS OFFICE ON DRUGS AND CRIME SECRETARIAT

  • Juana Tomas-Rossello
    Drug Abuse Treatment Adviser, Global Challenges Section
    Vienna
    Austria

WORLD HEALTH ORGANIZATION SECRETARIAT

Department of Mental Health and Substance Abuse

  • Vladimir Poznyak
    Co-ordinator
  • Nicolas Clark
    Medical Officer
  • Hannu Alho
    Temporary Advisor (seconded from the national Public Health Institute of Finland [KTL])

Department of HIV

  • Annette Verster
    Technical Officer

Department of Health Systems Financing

  • Dan Chisholm
    Economist

Department of Medicines Policy and Standards

  • Sue Hill
    Medical Officer
  • Nicola Magrini
    Medical Officer

Other contributors

WHO would also like to acknowledge the contribution made by the following individuals in the development of background materials and peer review:

  • Laura Amato, Department of epidemiology, Azienda Sanitaria locale “E”, Rome, Italy
  • Mike Ashton, Drug and Alcohol Findings, United Kingdom
  • Anna Maria Bargagli, Department of epidemiology, Azienda Sanitaria locale “E”, Rome, Italy
  • James Bell, national Addiction Centre, London, United Kingdom
  • Adrian Carter, Queensland Brain Institute, University of Queensland, Australia
  • Zhang Cunmin, Yunnan Institute for Drug Abuse, Kunming, Yunnan, China
  • Chris Doran, national Drug & Alcohol Research Centre, University of new South Wales, Australia
  • Colin Drummond, St George's, University of London, United Kingdom
  • Ralph Edwards, Director, Uppsala Monitoring Centre, Sweden
  • Gabriele Fischer, Medical University of Vienna, Austria
  • Andy Gray, University of KwaZulu-Natal, Durban, South Africa
  • Wayne Hall, School of Population Health, University of Queensland, Australia
  • S Kattimani, national Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India
  • Nina Kopf, Department of Psychiatry, Medical University of Vienna, Austria
  • T Ladjevic, Research Institute for Public Health and Addiction. Zurich University, Switzerland
  • Lisa Marsch, Center for Drug Use and HIV Research, national Development and Research Institutes, New York, USA
  • Silvia Minozzi, Department of epidemiology, Azienda Sanitaria locale “E”, Rome, Italy
  • Lubomir Okruhlica, Institute for Drug Dependencies, Centre for Treatment of Drug Dependencies, Bratislava, Slovak Republic
  • Katherine Perryman, St George's, University of London, United Kingdom
  • Carlo Perucci, Department of epidemiology, Azienda Sanitaria locale “E”, Rome, Italy
  • Li Peikai, Yunnan Institute for Drug Abuse, Kunming, Yunnan, China
  • Jurgen Rehm, Research Institute for Public Health and Addiction. Zurich University, Centre for Addiction and Mental Health, Toronto, Canada
  • H K Sharma, national Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India
  • Simona Vecchi, Department of epidemiology, Azienda Sanitaria locale “E”, Rome, Italy

Declaration of interests of the guidelines development group

Michael Farrell reported being a member of the National Guidelines Group on Substance Dependence in the United Kingdom, receiving travel support and expenses for speaking at meetings from Reckitt Benckiser and Schering Plough (value <$1000 each occasion), and in collaboration with the University of Adelaide and the University of California, Los Angeles, receiving an unrestricted educational grant from Reckitt Benckiser (through the University of Adelaide) to organize a meeting on substance dependence in South East Asia, with no personal payments from the grant.

David Fiellin reported providing expert opinion at a congressional press conference related to treatment of substance dependence, and providing an expert review of methadone, buprenorphine and buprenorphine/naloxone for the United States Centre for Substance Abuse treatment, with no honorariums.

Richard Mattick reported providing advice and public statements on treatment of substance dependence in his role as Director of the National Drug and Alcohol Research Centre, receiving research support to his research unit as an untied educational grant from Reckitt Benckiser (value approximately $AU400 000 over 3 years), but without personal payment, and receiving research support to his research unit from the Australian National Health and Medical Research Council for research on substance dependence (value approximately $AU150 000).

Rajat Ray reported being a member of the Indian Expert Group for the Ministry of Health, India, on opioid substitution treatment and presenting a scientific paper on the topic in 2005, receiving funding for his research unit from Rusan Pharmaceuticals (value $US350 000) for research related to buprenorphine, with no personal payments.

Ambrose Uchtenhagen reported receiving funding for a literature review at least 3 years ago from Schering Plough.

Marina Davoli, Ratna Mardiati, Afarin Rahimi Movaghar, Fred Owiti, Emilis Subata, Anthony Smith, and Gabrielle Welle-Strand reported no conflict of interest.

Organizations providing feedback on the draft guidelines

  • WHO Regional Offices
  • WHO Collaborating Centres

    Addiction Research Institute, Zurich, Switzerland

    Centre for Addiction and Mental Health, Toronto, Canada

    College on Problems of Drug Dependence, Vermont, Unites States

    Drug and Alcohol Services Council, Adelaide, Australia

    Institute of Health Science Research, Bangkok, Thailand

    Mental Health Institute, Hunan, China

    National Drug Research Institute, Perth, Australia

  • Other organizations

    American Association for the Treatment of Opioid Dependence

    American College of Neuropsychopharmacology

    American Society of Addiction Medicine

    International Harm Reduction Association

    International Center for Advancement of Addiction Treatment (ICAAT)

    National Alliance of Methadone Advocates, New York, United States

    National Institute on Drug Abuse, United States

    National Institute for Health and Clinical Excellence (NICE), United Kingdom

    Quest for Quality, the Netherlands

    Service d'Abus de Substances, Département de Psychiatrie, Genève

    South African National Council on Alcohol and Drug Dependence

    Turning Point Alcohol & Drug Centre, Melbourne, Australia

    World Psychiatric Association

    South African National Council on Alcohol and Drug Dependence

    Turning Point Alcohol & Drug Centre, Melbourne, Australia

    World Psychiatric Association

Copyright © 2009, World Health Organization.

All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: tni.ohw@sredrokoob). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: tni.ohw@snoissimrep).

Bookshelf ID: NBK143165

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