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Guidelines on the Management of Latent Tuberculosis Infection. Geneva: World Health Organization; 2015.

Cover of Guidelines on the Management of Latent Tuberculosis Infection

Guidelines on the Management of Latent Tuberculosis Infection.

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Acknowledgements

Overall coordination and writing of the guidelines

Haileyesus Getahun and Alberto Matteelli helped coordinate the development and drafting of the guidelines, under the overall direction of Mario Raviglione.

WHO Steering Group

Dennis Falzon (Global TB Programme, WHO), Nathan Ford (HIV/AIDS Department, WHO), Haileyesus Getahun (Global TB Programme, WHO), Chris Gilpin (Global TB Programme, WHO), Christian Lienhardt (Global TB Programme, WHO), Knut Lonnroth (Global TB Programme, WHO), Alberto Matteelli (Global TB Programme, WHO), Lisa Nelson (HIV/AIDS Department, WHO), Andreas Reis (Knowledge, Ethics and Research Department, WHO), Mukund Uplekar (Global TB Programme, WHO).

Co-chairs of the WHO Guidelines Development Group

Holger Schünemann (McMaster University Health Sciences Centre, Canada); Jay Varma (US Centers for Diseases Control and Prevention, USA).

GRADE methodologist of the WHO Guidelines Development Group

Holger Schünemann (McMaster University Health Sciences Centre, Canada).

Members of WHO Guidelines Development Group

Ibrahim Abubakar (National Centre for Infectious Disease Surveillance and Control, University College London and Public Health England, London, United Kingdom of Great Britain and Northern Ireland); Draurio Barreira (National TB Programme, Ministry of Health, Brasilia, Brazil); Susana Marta Borroto Gutierrez (Pedro Kourí Institute of Tropical Medicine, La Habana, Cuba); Judith Bruchfeld (Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden); Erlina Burhan (Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia); Solange Cavalcante (Rio de Janeiro Municipal Health Secretariat FIOCRUZ, Rio de Janeiro, Brazil); Rolando Cedillos (Servicio de Infectología y Programade Atención Integral en ITS/VIH/SIDA, San Salvador, El Salvador); Cynthia Bin-Eng Chee (Tan Tock Seng Hospital, Singapore); Richard Chaisson (Center for TB Research, John Hopkins University, USA); Lucy Chesire (TB Advocacy Consortium, Nairobi, Kenya); Elizabeth Corbett (London School of Hygiene and Tropical Medicine, Blantyre, Malawi); Justin Denholm (Royal Melbourne Hospital, Melbourne, Australia); Gerard de Vries (KNCV TB Foundation, Den Haag, The Netherlands); Margaret Gale-Rowe (Public Health Agency of Canada, Ottawa, Canada); Un-Yeong Go (Department of HIV/AIDS and TB Control Korea, Korea Centers for Disease Control and Prevention, Republic of Korea); Alison Grant (London School of Hygiene and Tropical Medicine, London, United Kingdom of Great Britain and Northern Ireland); Robert Horsburgh (Department of Epidemiology, Boston University School of Public Health, Boston, USA); Asker Ismayilov (Main Medical Department, Ministry of Justice, Azerbaijan); Philippe LoBue (Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, USA); Guy Marks (Woolcock Institute of Medical Research University of Sydney, Sydney, Australia); Richard Menzies (Respiratory Division, McGill University, and Montreal Chest Institute, Montreal, Canada); Giovanni Battista Migliori (WHO Collaborating Centre for TB and Lung Diseases Fondazione S. Maugeri, Tradate, Italy); Davide Mosca (Migration Health Department, International Organization of Migration, Geneva, Switzerland); Ya Diul Mukadi (Infectious Disease Division, Bureau for Global Health, US Agency for International Development, Washington, USA); Alwyn Mwinga (Zambart Project, Lusaka, Zambia); Lisa Rotz (Centers for Disease Control and Prevention, Atlanta, USA); Holger Schünemann (Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada); Surender Kumar Sharma (Department of Medicine, All India Institute of Medical Sciences, New Delhi, India); Timothy Sterling (Vanderbilt University School of Medicine, Nashville, USA); Tamara Tayeb (National TB Programme, Ministry of Health, Riyadh, Saudi Arabia); Marieke van der Werf (European Centre for Disease Prevention and Control, Stockholm, Sweden); Wim Vandevelde (European AIDS Treatment Group, Brussels, Belgium); Jay Varma (US Centers for Diseases Control and Prevention, USA); Natalia Vezhnina (Regional Advisor on HIV/TB and Penal System Projects, Russian Federation); Constantia Voniatis (Coordinator of Clinical Laboratories, Ministry of Health, Nicosia, Cyprus); Robert John Wilkinson (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa); Takashi Yoshiyama (Division of Respiratory Medicine, Japan Anti-Tuberculosis Association, Tokyo, Japan); Jean Pierre Zellweger (Medical Adviser, Tuberculosis Competence Centre, Berne, Switzerland).

WHO Consultants for Systematic Reviews

Saskia Den Boon (Independent consultant, United Kingdom of Great Britain and Northern Ireland); Esmee Doets (Pallas health research and consultancy BV, Rotterdam, The Netherlands); Enrico Girardi (Istituto Nazionale Malattie Infettive L. Spallanzani, Rome, Italy); Darshini Govindasamy (independent consultant, South Africa), Ross Harris (Public Health England, London, United Kingdom of Great Britain and Northern Ireland); Sandra Kik (Mc Gill University, Montreal, Canada); Katharina Kranzer (Department of Infectious Disease and Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom of Great Britain and Northern Ireland); Anouk Oordt-Speets (Pallas health research and consultancy BV, Rotterdam, The Netherlands); Molebogeng Rangaka (Public Health England, London, United Kingdom of Great Britain and Northern Ireland); Monica Sane Schepisi (Istituto Nazionale Malattie Infettive L. Spallanzani, Rome, Italy); Giovanni Sotgiu (Sassari University, Sassari, Italy); Helen Stagg (Public Health England, London, United Kingdom of Great Britain and Northern Ireland); Femke van Kessel (Pallas health research and consultancy BV, Rotterdam, The Netherlands); Anja van't Hoog (Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands).

Peer reviewers

Amy Bloom (US Agency for International Development (USAID), USA); Graham Bothamley (Tuberculosis Network, European Study Group Clinical trials, United Kingdom of Great Britain and Northern Ireland); Gavin Churchyard (The Aurum Institute, South Africa); Daniela Maria Cirillo (San Raffaele del Monte Tabor Foundation, San Raffaele Scientific Institute, Milan, Italy); Raquel Duarte (General Directorate of Health, Portugal); Michel Gasana (National TB Programme, Rwanda); Stephen Graham (Centre for International Child Health, Australia); Connie Erkens (KNCV Tuberculosis Foundation, The Netherlands); Brian Farrugia (Geriatric Medicine and Chest Clinic, Malta); Barbara Hauer (Robert Koch Institute, Germany); Diane Havlir (University of California, San Francisco, USA); Einar Heldal (The International Union against TB and Lung Diseases, Norway); Rein Houben (Tuberculosis Modelling and Analysis Consortium, United Kingdom of Great Britain and Northern Ireland); Mohamed Akramul Islam (BRAC Health Programme, Bangladesh); Jerker Jonsson (Swedish Institute for Infectious Disease Control, Sweden); Michael Kimerling (Bill & Melinda Gates Foundation, USA); Christopher Lange (Clinical Infectious Diseases, Medical Clinic Research Center, Borstel, Germany); Wang Lixia (National Centre for TB control and Prevention, China); Joan O'Donnell (National Disease Surveillance Unit, Ireland); Anshu Prakash (Ministry of Health and Family Welfare, India); Ejaz Qadeer (National TB Control Programme, Federal Ministry of Health, Pakistan); Lidija Ristic (Committee for TB, Ministry of Health, Serbia); Laura Sanchez-Cambronero (Ministry of Health, Social Services and Equality, Spain); Martina Sester (Saarland University, Germany); Joseph Kimagut Sitienei (Ministry of Public Health, Kenya); Alena Skrahina (Republic Scientific and Practical Center for Pulmonology and Tuberculosis, Minsk, Belarus); Soumya Swaminathan (National Institute for Research in Tuberculosis, Chennai, India); Ivan Solovic (National Institute for TB, Lung Diseases and Thoracic Surgery, Vysne Hagy, Slovakia); Elena Suciliene (Children Hospital, affiliate of Vilnius University Hospital santariskiu Klinikos, Czech Republic); Maarten van Cleeff (Project Director TBCTA, KNCV Tuberculosis Foundation, The Netherlands); Francis Varaine (International Medical Co-ordinator, Médecins sans Frontières, France); Martina Vasakova (Respiratory Diseases and Pulmonology Department at Thomayer Hospital Prague, Czech Republic); Irina Vasilyeva (Ministry of Health, Russian Federation); Mercedes Vinuesa Sebastián (Ministry of Health, Spain); Brita Askeland Winje (Norwegian Institute of Public Health, Norway); Dalene von Delft (TB PROOF, Cape Town, South Africa); Dominik Zenner (Public Health England, United Kingdom of Great Britain and Northern Ireland).

WHO Headquarters and Regional offices

Mohamed Abdel Aziz (WHO/ EMRO); Masoud Dara (WHO/EURO); Malgorzata Grzemska (WHO/HQ); Ernesto Jaramillo (WHO/HQ); Nobuyuki Nishikiori (WHO/WPRO); Diana Weil (WHO/HQ); Karin Weyer (WHO/HQ).

Acknowledgement of financial support

The development of these guidelines was financially supported by the Ministry of Health of Italy. Core WHO funds were used as well. The European Centre for Disease Prevention and Control supported the systematic review entitled “What interventions are effective to improve initiation, adherence and completion of LTBI treatment?”, through a contract to Pallas health research and consultancy BV. Similarly Public Health England supported the systematic reviews on “Predictive utility of the tuberculin skin test and interferon-gamma release assay among individuals who are not prescribed tuberculosis preventive therapy” and “Systematic literature review and meta-analysis on the best treatment options for latent tuberculosis infection”.

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Bookshelf ID: NBK293807