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Guidelines on the Management of Latent Tuberculosis Infection. Geneva: World Health Organization; 2015.

Cover of Guidelines on the Management of Latent Tuberculosis Infection

Guidelines on the Management of Latent Tuberculosis Infection.

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Annex 3Recommended drug dosage

Drug regimenDose per body weightMaximum dose
Daily Isoniazid alone for 6 or 9 monthsAdults = 5 mg/kg
Children = 10 mg/kg		300 mg
Daily Rifampicin alone for 3-4 monthsAdults= 10 mg/kg
Children = 10 mg/kg		600 mg
Daily isoniazid plus rifampicin for 3–4 monthsIsoniazid
Adults = 5 mg/kg
Children = 10 mg/kg
Rifampicin
Adults and children = 10 mg/kg		Isoniazid = 300 mg
Rifampicin= 600 mg
Weekly rifapentine plus isoniazid for 3 months (12 doses)Adults and Children
Isoniazid: 15 mg/kg
Rifapentine (by body weight):
10.0–14.0 kg = 300 mg
14.1–25.0 kg = 450 mg
25.1–32.0 kg = 600 mg
32.1–49.9 kg = 750 mg		Isoniazid = 900 mg
Rifapentine = 900 mg
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Bookshelf ID: NBK293811
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