Summary of findings tables

Web Annex 8Summary of findings tables

Acknowledgement

The World Health Organization (WHO) wishes to express its appreciation to the following individuals, who contributed to the development of this document: Marc Bulterys, WHO, Geneva, Switzerland; Patrice Cacoub, La Pitié-Salpêtrière Hospital, Paris, France; Roger Chou, Oregon Health and Science University, Portland, United States of America (USA); Giuseppe Indolfi, Meyer Children’s University Hospital, Florence, Italy; Judith van Holten, WHO, Geneva, Switzerland; Yvan Hutin, WHO, Geneva, Switzerland; Michael Zoratti, Zoratti HEOR Consulting, Hamilton, Canada.

Question: SVR compared to non-SVR in persons with chronic HCV infection and extrahepatic symptoms¹

Bibliography: Systematic review and meta-analysis to support the development of the WHO guidelines for the treatment of persons with chronic hepatitis C infection. P Cacoub, Sorbonne University, Paris, France

Table 1. Summary of findings table of systematic review on the impact of SVR on extrahepatic manifestations of chronic hepatitis C (PDF, 545K)

Table 2. Summary of findings table and GRADE evidence profile for patients treated with glecaprevir + pibrentasvir, all-comer analysis, arranged by genotype (PDF, 562K)

Table 3. Summary of findings table and GRADE evidence profile for patients treated with daclatasvir + sofosbuvir, all-comer analysis, arranged by genotype (PDF, 581K)

Table 4. Summary of findings table and GRADE evidence profile for patients treated with sofosbuvir + velpatasvir, all-comer analysis, arranged by genotype (PDF, 554K)

Question: Direct acting antiviral therapy compared to interferon based antiviral therapy in adolescents and children with chronic hepatitis C infection

Bibliography: Systematic review and meta-analyses on the efficacy and safety of direct acting antiviral combinations compared to pegylated interferon alfa 2a or alfa 2b plus ribavirin for the treatment of chronic hepatitis C in adolescents and children, Giuseppe Indolfi, Meyer Children’s University Hospital of Florence.

Table 5. Summary of findings table of the systematic review on treatment of chronic HCV infection in children and adolescents (PDF, 527K)

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NLM Citation

Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection [Internet]. Geneva: World Health Organization; 2018 Jul. Web Annex 8, Summary of findings tables.