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Contents
- List of Contributors
- Acknowledgements
- Abbreviation List
- 1. EndotheliumPaul Kerr, Raymond Tam, and Frances Plane.
- 2. Vascular Smooth Muscle Structure and FunctionDavid P Wilson.
- Introduction
- Smooth Muscle (Vascular) Structure
- Cytoskeleton
- Contractile Myofilament
- Functional Regulation of Vascular Smooth Muscle: Neuronal, Hormonal, Receptor Mediated
- Smooth Muscle Function
- Myofilament Basis of Smooth Muscle Contraction and Relaxation
- Ion Channels Important in the Regulation of Smooth Muscle Function
- Endothelial Regulation of Smooth Muscle Vasodilatation
- Smooth Muscle Proliferation and Vascular Remodelling
- Summary
- References
- 3. AtherosclerosisGillian Cockerill and Qingbo Xu.
- 4. Mechanisms of Plaque RuptureIan Loftus.
- 5. Current and Emerging Therapies in AtheroprotectionStephen Nicholls and Rishi Puri.
- 6. Molecular Approaches to Revascularization in Peripheral Vascular DiseaseGreg S. Mcmahon and Mark J. Mccarthy.
- 7. Biology of Restenosis and Targets for InterventionRichard D. Kenagy.
- 8. Vascular Arterial HaemodynamicsMichael MD Lawence-Brown, Kurt Liffman, James B Semmens, and Ilija D Sutalo.
- Introduction
- Laplace’s Law of Wall Tension
- Newtonian Fluid
- Non-Newtonian Fluid
- Poiseuille Flow
- Bernoulli’s Equation
- Young’s Modulus and Pulsatile Flow
- Mass Conversion
- Reynold’s Number
- Arterial Dissection, Collateral Circulation and Competing Flows
- Shear Stress and Pressure
- Forces on Graft Systems
- Computational Modelling
- Recent Developments and Future Directions
- Conclusion
- References
- 9. Physiological HaemostasisSimon McRae.
- 10. Hypercoagulable StatesSimon McRae.
- 11. Platelets in the Pathogenesis of Vascular Disease and their Role as a Therapeutic TargetSandeep Prabhu, Rahul Sharma, and Karlheinz Peter.
- 12. Pathogenesis of Aortic AneurysmsJonathan Golledge, Guo-Ping Shi, and Paul Norman.
- Introduction
- Differences between Thoracic and Abdominal Aortic Aneurysms
- Summary of Current Theories and Stages of AAA Evolution
- Atherosclerosis and AAA
- Immune Mechanisms in AAA
- Extracellular Matrix Dysfunction
- Infection
- Biomechanical Forces
- Angiogenesis
- Intra-Luminal Thrombus
- Extracellular Matrix Proteolysis
- Genetics
- AAA Rupture
- Future Research
- References
- 13. Pharmacological Treatment of AneurysmsMatthew Thompson and Janet T Powell.
- 14. Pathophysiology of Aortic Dissection and Connective Tissue DisordersMark Hamilton.
- 15. Biomarkers in Vascular DiseaseIan M. Nordon and Robert J. Hinchliffe.
- Introduction
- What is a Biomarker?
- Types of Biomarker
- Potential Value of Biomarkers in Vascular Disease
- Biomarker Discovery Steps
- AAA Biomarkers
- Biomarkers of AAA Rupture
- Biomarkers Following Endovascular Repair
- Biomarkers of Carotid Plaque Stability
- Challenges in Biomarker Discovery
- Future Work
- Conclusion
- Key References
- 16. Pathophysiology and Principles of Management of Vasculitides and Raynaud’s SyndromeMartin Veller.
- Vasculitides
- Introduction
- Classification of Vasculitides
- Clinical Presentation of Vasculitides
- Investigations of Vasculitides
- Principles of Treatment of Vasculitides
- The Vasculitides of Specific Interest to Vascular Surgeons
- Pathophysiology and Principles of Treatment of Raynaud’s Phenomenon
- Prognosis
- Treatment
- Recommendations
- References and Suggested Reading
- 17. SIRS, Sepsis and Multiorgan FailureVishwanath Biradar and John L Moran.
- 18. Pathophysiology of Reperfusion InjuryPrue Cowled and Robert Fitridge.
- 19. Compartment SyndromesEdward Choke, Robert Sayers, and Matthes Born.
- 20. Pathophysiology of PainStephan A. Schug, Helen C. S. Daly, and Kathryn J.D. Stannard.
- 21. Post-amputation PainStephan A. Schug and Gail Gillespie.
- Introduction
- Classification and Incidence of Post- Amputation Pain Syndromes
- Pathophysiology of Post- Amputation Pain Syndromes
- Current Pathophysiological Model of Post-Amputation Pain Syndromes
- Prevention of Post- Amputation Pain
- Evaluation of the Patient With Post-Amputation Pain Syndromes
- Therapy of Post-Amputation Pain Syndromes
- Future Aims
- References
- 22. Treatment of Neuropathic PainStephan A Schug and Kathryn JD Stannard.
- 23. Principles of Wound HealingGregory S. Schultz, Gloria A. Chin, Lyle Moldawer, and Robert F. Diegelmann.
- 24. Pathophysiology and Principles of Management of Varicose VeinsAndrew W Bradbury.
- 25. Chronic Venous Insufficiency and Leg Ulceration: Principles and Vascular BiologyMichael Stacey.
- 26. Pathophysiology and Principles of Management of the Diabetic FootDavid G. Armstrong, Timothy K. Fisher, Brian Lepow, Matthew L. White, and Joseph L. Mills.
- 27. Lymphoedema – Principles, Genetics and PathophysiologyMatt Waltham.
- 28. Graft Materials Past and FutureMital Desai and George Hamilton.
- 29. Pathophysiology of Vascular Graft InfectionsMauro Vicaretti.
- Introduction
- Natural History of Prosthetic Vascular Graft Infections
- Mechanisms of Graft Contamination at Operation
- Pathogenesis of Graft Infections
- Bacteriology of Vascular Graft Infections
- Investigations for Detection of Prosthetic Graft Infections
- Management of Prosthetic Graft Infections
- Established Infection
- Conclusion
- References
- Mechanisms of Vascular DiseaseMechanisms of Vascular Disease
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