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Duffy L, Lewis G, Ades A, et al. Antidepressant treatment with sertraline for adults with depressive symptoms in primary care: the PANDA research programme including RCT. Southampton (UK): NIHR Journals Library; 2019 Dec. (Programme Grants for Applied Research, No. 7.10.)

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Antidepressant treatment with sertraline for adults with depressive symptoms in primary care: the PANDA research programme including RCT.

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Acknowledgements

We are grateful to all the patients who took part in the PANDA studies. We would like to thank the GPs and GP surgery staff who supported recruitment for this research. We have been supported by the following Clinical Research Networks (CRNs): North Thames CRN, CRN North West London, CRN South London, North West Coast CRN, Greater Manchester CRN, West Midlands CRN, West of England CRN, Yorkshire and Humber CRN and North East and Cumbria CRN.

We would like to acknowledge the particular input of the CRN research nurses and CSOs: Dawn Adams, Heather Tinker, Lynsey Wilson, Tara Harvey, Khatiba Raja, Zara Prem, Beena Bauluck, Yvonne Foreshaw, Cynthia Sajani, Jahnese Maya, Anna Townsend-Rose, Emily Clare, Rachel Nixon, Pam Clark and Irene Sambath.

We would also like to acknowledge Vivien Jones for providing administrative support at the Bristol site; Rebecca Rawlinson at the Liverpool site; Bryony Thomson and Yvonne Donkor at University College London; and Wendy Cattle at York. Jodi Prem was instrumental in recruitment at York.

We also thank Carolyn Chew-Graham, Ian Anderson, Anne Rogers, Evan Kontopantelis, Paul Lanham, Christopher Williams, Richard Bying and Obi Ukoumunne for generously agreeing to sit on the Trial Steering Committee and Data Monitoring Committee.

Ethics approval and sponsorships

For the PANDA cohort study, ethics approval was obtained from National Research Ethics Service (NRES) Committee South West-Central Bristol. The University of Bristol acted as sponsor for the study.

The PANDA RCT was approved by NRES Committee East of England – Cambridge South (reference number 13/EE/0418). The Joint Research Office, University College London acted as sponsor for the RCT.

Contributions of authors

Larisa Duffy was the programme manager and with Gemma Lewis was responsible for drafting the report.

Larisa Duffy, Gemma Lewis, Anthony Ades, Ricardo Araya, Jessica Bone, Sally Brabyn, Katherine Button, Rachel Churchill, Tim Croudace, Catherine Derrick, Padraig Dixon, Christopher Dowrick, Christopher Fawsitt, Louise Fusco, Simon Gilbody, Catherine Harmer, Catherine Hobbs, William Hollingworth, Vivien Jones, Tony Kendrick, David Kessler, Naila Khan, Daphne Kounali, Paul Lanham, Alice Malpass, Marcus Munafo, Jodi Pervin, Tim Peters, Derek Riozzie, Jude Robinson, George Salaminios, Debbie Sharp, Howard Thom, Laura Thomas, Nicky Welton, Nicola Wiles, Rebecca Woodhouse and Glyn Lewis contributed to the constituent papers in the appendices. The papers included as appendices each have its own lists of authors.

Anthony Ades, Ricardo Araya, Rachel Churchill, Tim Croudace, Christopher Dowrick, Simon Gilbody, William Hollingworth, Tony Kendrick, David Kessler, Paul Lanham, Alice Malpass, Tim Peters, Jude Robinson, Debbie Sharp, Nicky Welton, Nicola Wiles and Glyn Lewis were responsible for the original proposal and for securing funding.

Glyn Lewis was chief investigator of the programme and had clinical responsibly for the RCT recruitment at the London site.

All authors have provided substantial contributions to the conception and design of the PANDA programme and interpretation of data and had input into drafting the report and/or revising it critically for important intellectual content. All authors have given final approval of the version to be published.

Data-sharing statement

All data requests should be submitted to the corresponding author for consideration. Access to available anonymised data may be granted following review.

Patient data

This work uses data provided by patients and collected by the NHS as part of their care and support. Using patient data is vital to improve health and care for everyone. There is huge potential to make better use of information from people’s patient records, to understand more about disease, develop new treatments, monitor safety, and plan NHS services. Patient data should be kept safe and secure, to protect everyone’s privacy, and it’s important that there are safeguards to make sure that it is stored and used responsibly. Everyone should be able to find out about how patient data are used. #datasaveslives You can find out more about the background to this citation here: https://understandingpatientdata.org.uk/data-citation.

Disclaimers

This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, CCF, NETSCC, PGfAR or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the PGfAR programme or the Department of Health and Social Care.

Copyright © Queen’s Printer and Controller of HMSO 2019. This work was produced by Duffy et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK551194

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