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Ramanan AV, Dick AD, Jones AP, et al. Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT. Southampton (UK): NIHR Journals Library; 2019 Apr. (Health Technology Assessment, No. 23.15.)

Cover of Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT

Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT.

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List of abbreviations

AC

anterior chamber

ACR

American College of Rheumatology

A&E

accident and emergency

AE

adverse event

AIC

Akaike information criterion

CHAQ

Childhood Health Assessment Questionnaire

CHQ

Childhood Health Questionnaire

CI

confidence interval

CR

credible range

CRF

case report form

CTRC

Clinical Trials Research Centre

DIC

deviance information criterion

DMARD

disease-modifying antirheumatic drugs

GFR

glomerular filtration rate

GP

general practitioner

HR

hazard ratio

HRG

Healthcare Resource Group

HUI

Health Utilities Index

HUI2

Health Utility Index Mark 2

HUI3

Health Utility Index Mark 3

ICER

incremental cost-effectiveness ratio

IDSMC

Independent Data and Safety Monitoring Committee

IMP

investigational medicinal product

IOP

intraocular pressure

ITT

intention to treat

JADAS

Juvenile Arthritis Disease Activity Score

JIA

juvenile idiopathic arthritis

LMM

linear missed model

logMAR

logarithm of the minimum angle of resolution

MTX

methotrexate

PAS

patient administration systems

PhS

physical subscale

PLICS

patient-level information and costing systems

PsS

psychosocial subscale

QALY

quality-adjusted life-year

RF

rheumatoid factor

RR

relative risk

SAE

serious adverse event

SAP

statistical analysis plan

SAS PROC

Statistical Analysis Systems Procedure

SD

standard deviation

SE

standard error

SUN

Standardisation of Uveitis Nomenclature

SYCAMORE

a randomised controlled trial of the clinical effectiveness, SafetY and Cost-effectiveness of Adalimumab in Combination with MethOtRExate for the treatment of juvenile idiopathic arthritis associated uveitis

TMG

Trial Management Group

TNF-α

tumour necrosis factor alpha

TSC

Trial Steering Committee

VI

visual impairment

Copyright © Queen’s Printer and Controller of HMSO 2019. This work was produced by Ramanan et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.
Bookshelf ID: NBK539602
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