| Abrams and Hallett 2013360 | Not a SR or primary prospective study |
| Adar et al. 1977361 | Not a SR or primary prospective study |
| Aguilar-Ferrandiz et al. 2011283 | Not relevant comparator (psychological techniques) |
| Ak et al. 2013362 | No intervention |
| Ak et al. 2013363 | No intervention |
| Aksu et al. 2011281 | Not a SR or primary prospective study |
| Alvarez et al. 2013231 | Not a SR or primary prospective study |
| Alvarez et al. 2013224 | Not a SR or primary prospective study |
| Ambrogi et al. 2009272 | Not relevant comparator (sympathectomy) |
| Amini et al. 2008217 | Not a SR or primary prospective study |
| Amir et al. 2000186 | No intervention |
| Andrade et al. 2012208 | Not dermatology study: sympathectomy |
| Andrews and Rennie 1997364 | Not dermatology study: sympathectomy |
| Anonymous 2004365 | Not a SR or primary prospective study |
| Araujo et al. 2009366 | Not dermatology study: sympathectomy |
| Atkinson et al. 2010367 | Not a SR or primary prospective study |
| Attia and Salah 2011219 | Not relevant intervention (photodynamic therapy) |
| Awad et al. 2010368 | Not dermatology study: sympathectomy |
| Aydemir and Toh 2006369 | Not relevant intervention (comparison of specific techniques) |
| Bachmann et al. 2009317 | Not a SR or primary prospective study |
| Bandeira et al. 2009370 | Not a SR or primary prospective study |
| Basra et al. 2008275 | Not primary hyperhidrosis |
| Baumgartner and Toh 2003371 | Not a SR or primary prospective study |
| Baumgartner et al. 2009372 | Not a comparative study (treatments undertaken sequentially) |
| Bechaux 2009373 | Not a SR or primary prospective study |
| Bell et al. 2014374 | Not a SR or primary prospective study |
| Benohanian et al. 1998375 | Not relevant intervention (aluminium chloride) |
| Birnie and Motley 2009268 | Not a SR or primary prospective study |
| Bischof et al. 2005376 | Not dermatology study: sympathectomy |
| Bisseriex et al. 2012377 | Not primary hyperhidrosis |
| Boas 2000378 | Not a SR or primary prospective study |
| Boley et al. 2007319 | Not dermatology study: sympathectomy |
| Bryan et al. 2012379 | Not a SR or primary prospective study |
| Bygstad et al. 2013380 | Not dermatology study: sympathectomy |
| Cameron and Ojimba 2004381 | Not a SR or primary prospective study |
| Cardoso et al. 2009320 | Not a SR or primary prospective study |
| Cerfolio et al. 201115 | Not a SR or primary prospective study |
| Chan et al. 2007321 | Not dermatology study: sympathectomy |
| Chen et al. 1996382 | Not a SR or primary prospective study |
| Chen et al. 2001383 | Not dermatology study: sympathectomy |
| Chen et al. 2013384 | Not dermatology study: sympathectomy |
| Cheng et al. 2015334 | Not dermatology study: sympathectomy |
| Chia et al. 2012385 | Not relevant intervention (glycopyrronium bromide iontophoresis) |
| Cho et al. 1994386 | Not relevant comparator (aluminium chloride and sympathectomy) |
| Cinà and Clase 1999292 | No intervention |
| Clerico et al. 2014387 | Not a SR or primary prospective study |
| Coelho et al. 2014388 | Not dermatology study: sympathectomy |
| Copleymerriman et al. 2015389 | Not primary hyperhidrosis |
| Coveliers et al. 2011215 | Not dermatology study: sympathectomy |
| Currie et al. 2011322 | Not a SR or primary prospective study |
| Davarian et al. 2008264 | Not relevant intervention (BTX iontophoresis vs. saline) |
| de Campos et al. 2003238 | Not dermatology study: sympathectomy |
| de Campos et al. 2005390 | Not dermatology study: sympathectomy |
| Delaplace et al. 2015211 | Not dermatology study: sympathectomy |
| Deng et al. 2011391 | Not dermatology study: sympathectomy |
| Dickmann and Dickmann 20102 | Not a SR or primary prospective study |
| Divisi et al. 2013323 | Not dermatology study: sympathectomy |
| Doolabh et al. 2004392 | Not a SR or primary prospective study |
| Dressler et al. 2002393 | Not relevant intervention (comparing different doses of BTX) |
| Drott et al. 1995394 | Not a SR or primary prospective study |
| Drott and Claes 1996395 | Not a SR or primary prospective study |
| Duarte et al. 2003396 | Not dermatology study: sympathectomy |
| Dumont et al. 1997397 | Not dermatology study: sympathectomy |
| Ebrahim 2011398 | Not dermatology study: sympathectomy |
| Edmondson et al. 1992399 | Not dermatology study: sympathectomy |
| Elia et al. 2005299 | Not dermatology study: sympathectomy |
| Ellis 1977400 | Not a SR or primary prospective study |
| Ellis and Scurr 1979401 | Not relevant intervention (aluminium chloride) |
| Ellis 1982402 | Not a SR or primary prospective study |
| Farahmand and Toolabi 2011403 | Not dermatology study: sympathectomy |
| Fatemi Naeini et al. 2015404 | Not a SR or primary prospective study |
| Flanagan et al. 2008218 | Not relevant comparator (aluminium chloride) |
| Flørenes 2003405 | Not dermatology study: sympathectomy |
| Flores 2012335 | Not a SR or primary prospective study |
| Fuentes et al. 2012207 | Not dermatology study: sympathectomy |
| Furlan et al. 2000406 | Not primary hyperhidrosis |
| Galati and Raposio 2010407 | Not a SR or primary prospective study |
| Garcia Franco et al. 2011210 | Not dermatology study: sympathectomy |
| Geddoa et al. 2008267 | Not a SR or primary prospective study |
| George et al. 2014408 | Not a SR or primary prospective study |
| Ghisletta et al. 1999409 | Not dermatology study: sympathectomy |
| Gibbons et al. 2014274 | Not a SR or primary prospective study (CEA) |
| Glent-Madsen and Dahl 1988410 | Not primary hyperhidrosis |
| Goh 1990411 | Not relevant intervention (aluminium chloride) |
| Goh and Yoyong 1996412 | Not relevant comparator (tannic acid) |
| Goh et al. 2000413 | Not dermatology study: sympathectomy |
| Goldman 2000414 | Not a SR or primary prospective study |
| Gorouhi et al. 2009220 | Not relevant comparator (aluminium chloride) |
| Gossot et al. 2001415 | Not a SR or primary prospective study |
| Grabham et al. 1998416 | Not dermatology study: sympathectomy |
| Gracia et al. 2011324 | Not dermatology study: sympathectomy |
| Greenhalgh et al. 1971417 | Not a SR or primary prospective study |
| Grimalt et al. 2006418 | Not relevant intervention (atropine) |
| Grootens and Hartong 2011419 | Not primary hyperhidrosis |
| Guérin et al. 1990420 | Not dermatology study: sympathectomy |
| Hasche et al. 1997156 | Duplicate report of Hasche et al. 1997156 |
| Hashmonai 2011421 | Not a SR or primary prospective study |
| Hecht et al. 2004422 | Not relevant intervention (comparing different doses of BTX) |
| Heidemann and Licht 2013423 | Not a SR or primary prospective study |
| Hekmat et al. 2010297 | Not a SR or primary prospective study |
| Henriques et al. 2014424 | Not a SR or primary prospective study |
| Henteleff and Kalavrouziotis 2008425 | Not dermatology study: sympathectomy |
| Hoorens and Ongenae 2012426 | Not a SR or primary prospective study |
| Hornberger et al. 2004189 | Not a SR or primary prospective study |
| Hsu et al. 1998427 | Not a SR or primary prospective study |
| Ibrahim et al. 2013245 | Not dermatology study: sympathectomy |
| Ibrahim et al. 2013428 | Not a SR or primary prospective study |
| Innocenzi et al. 2008429 | Not relevant intervention (aluminium sesquichlorhydrate foam) |
| Ishy et al. 2011239 | Not dermatology study: Ssympathectomy |
| Isla-Tajera et al. 2013230 | Not a dermatology study: quality of life/economics only |
| Ismail and El Samadoni 2015213 | Not a SR or primary prospective study |
| Jaffer et al. 2007336 | Not dermatology study: sympathectomy |
| Jani 2009430 | Not dermatology study: sympathectomy |
| Jeganathan et al. 2008325 | Not dermatology study: sympathectomy |
| Jog et al. 2010431 | Not primary hyperhidrosis |
| Kamudoni et al. 2012204 | No intervention |
| Kamudoni et al. 2014228 | No intervention |
| Kamudoni et al. 2015261 | No intervention |
| Kavanagh et al. 2004432 | Not a SR or primary prospective study |
| Kavanagh and Shams 2006433 | Not relevant intervention (BTX iontophoresis vs. saline) |
| Khademi Kalantari et al. 2011434 | Not relevant intervention (aluminium chloride) |
| Kim et al. 2005435 | Not dermatology study: sympathectomy |
| Kim et al. 200818 | Not a SR or primary prospective study |
| Kim et al. 2008436 | Not primary hyperhidrosis |
| Kopelman et al. 1996437 | Not a SR or primary prospective study |
| Koskinen et al. 2012308 | Not dermatology study: sympathectomy |
| Kravarusic and Freud 2012438 | Not a SR or primary prospective study |
| Krogstad et al. 2006439 | No intervention |
| Kuijpers et al. 2013282 | Not dermatology study: sympathectomy |
| Kumar et al. 2014440 | Not a SR or primary prospective study |
| Kuo et al. 2004259 | No intervention |
| Lakraj et al. 2013441 | Not a SR or primary prospective study |
| Lau et al. 2014442 | Not dermatology study: sympathectomy |
| Law and Ellis 1989443 | Not a SR or primary prospective study |
| Lawrence and Lonsdale Eccles 2006444 | Not a SR or primary prospective study |
| Leão et al. 2003445 | Not a SR or primary prospective study |
| Lecouflet et al. 2014446 | Not a SR or primary prospective study |
| Lee et al. 2004447 | Not dermatology study: sympathectomy |
| Lee and Ryman 2005448 | Not a SR or primary prospective study |
| Lee et al. 2006449 | Not primary hyperhidrosis |
| Lee et al. 2008450 | Not a SR or primary prospective study |
| Lessa et al. 2014284 | No intervention |
| Lewis et al. 1998451 | Not a SR or primary prospective study |
| Li et al. 201222 | Not primary hyperhidrosis |
| Licht and Pilegaard 2004452 | Not a SR or primary prospective study |
| Lin and Fang 1999453 | Not a SR or primary prospective study |
| Lin et al. 2000454 | Not a SR or primary prospective study |
| Lin 2001455 | Not dermatology study: sympathectomy |
| Little 2004456 | Not a SR or primary prospective study |
| Lladó et al. 2005457 | Not dermatology study: sympathectomy |
| Loureiro et al. 2008246 | Not dermatology study: sympathectomy |
| Lupin and Hong 2012209 | Duplicate report Lupin et al. 2011175 |
| Malmivaara et al. 2007458 | Not dermatology study: sympathectomy |
| Malone et al. 1986459 | Not dermatology study: sympathectomy |
| Marcella et al. 2011221 | Not a SR or primary prospective study |
| Masters and Rennie 1992460 | Not a SR or primary prospective study |
| McAleer et al. 2009265 | Not a SR or primary prospective study |
| Mehrotra et al. 2014229 | Not a SR or primary prospective study |
| Menna et al. 2012461 | Not dermatology study: sympathectomy |
| Micali et al. 2013266 | Not relevant intervention (aluminium chloride) |
| Misiak et al. 2012462 | Not dermatology study: sympathectomy |
| Montaser-Kouhsari et al. 2014463 | Not relevant intervention (BTX iontophoresis) |
| Mordant et al. 2010464 | Not a SR or primary prospective study |
| Moya et al. 2006465 | Not dermatology study: sympathectomy |
| Muhammad and Allam 2014466 | Not dermatology study: sympathectomy |
| Muller and Augustin 2013340 | Not dermatology study: quality of life/economics only |
| Munia et al. 2007328 | Not dermatology study: sympathectomy |
| Munia et al. 2008327 | Not dermatology study: sympathectomy |
| Nakamura et al. 2008467 | Not a SR or primary prospective study |
| Naumann and Hamm 2002468 | Not a SR or primary prospective study |
| Neidhardt et al. 2010469 | Not a SR or primary prospective study |
| Neumayer et al. 2003470 | Not dermatology study: sympathectomy |
| Neumayer et al. 2005471 | Not dermatology study: sympathectomy |
| Neumayer et al. 2005257 | Not dermatology study: sympathectomy |
| Neves et al. 2012247 | Not dermatology study: sympathectomy |
| Nicholson et al. 1994472 | Not dermatology study: sympathectomy |
| Nieuwenhuis 2015473 | Not a SR or primary prospective study |
| Odderson 1998474 | Not a SR or primary prospective study |
| Ojimba and Cameron 2004475 | Not a SR or primary prospective study |
| Oncel et al. 2012476 | Not dermatology study: sympathectomy |
| Panhofer et al. 2005233 | Not a SR or primary prospective study |
| Panhofer et al. 2006248 | Not dermatology study: sympathectomy |
| Panhofer et al. 2011242 | Not dermatology study: sympathectomy |
| Panhofer et al. 2013249 | Not dermatology study: sympathectomy |
| Panhofer et al. 2013241 | Not dermatology study: sympathectomy |
| Panhofer et al. 2014240 | Not dermatology study: sympathectomy |
| Pastorelli and Plasmati 2013214 | Not relevant intervention (comparison of BTX brands) |
| Pastorelli et al. 2014223 | Not relevant intervention (comparison of BTX brands) |
| Paul et al. 2010273 | Not relevant intervention (effect of laser hair removal on effectiveness of BTX) |
| Penna et al. 2007477 | No effectiveness or quality-of-life outcome |
| Phadke et al. 1995478 | Not relevant comparator (topical methenamide and glutaraldehyde) |
| Ponce-Olivera et al. 2014479 | Not a SR or primary prospective study |
| Prasad et al. 2010250 | Not dermatology study: sympathectomy |
| Purtuloglu et al. 2013480 | Not a SR or primary prospective study |
| Purtuloglu et al. 2013481 | Not a SR or primary prospective study |
| Raja and Campbell 2000482 | Not a SR or primary prospective study |
| Rameshkannan et al. 2010269 | Not relevant intervention (clonidine vs. propranolol) |
| Ramos et al. 2006483 | Not dermatology study: sympathectomy |
| Ramos et al. 2007484 | Not a SR or primary prospective study |
| Ramos et al. 2009485 | Not dermatology study: sympathectomy |
| Ramos et al. 2012486 | Not dermatology study: sympathectomy |
| Ramsaroop et al. 2004487 | Not dermatology study: sympathectomy |
| Rantanen and Telaranta 2013313 | Not dermatology study: sympathectomy |
| Rathinam et al. 2008329 | Not a SR or primary prospective study |
| Rayner et al. 1980488 | Not relevant intervention (aluminium chloride) |
| Rezai 2009489 | Not a SR or primary prospective study |
| Rezende and Luz 2014490 | Not a SR or primary prospective study |
| Rieger and Pedevilla 2007491 | Not dermatology study: sympathectomy |
| Rieger et al. 200917 | Not dermatology study: sympathectomy |
| Rieger et al. 2011492 | Not a SR or primary prospective study |
| Rieger et al. 2015251 | Not dermatology study: sympathectomy |
| Roddy 2012493 | Not a SR or primary prospective study |
| Rodriguez et al. 2008300 | Not dermatology study: sympathectomy |
| Rodriguez-Lopez et al. 2010494 | Not dermatology study: sympathectomy |
| Rzany et al. 2012227 | Not a dermatology study: quality of life/economics only |
| Saadia et al. 2001495 | Not relevant intervention (comparison of BTX doses) |
| Salek et al. 2015260 | Not primary hyperhidrosis |
| Sanli et al. 2010216 | Not a SR or primary prospective study |
| Scheer et al. 2014271 | Not a SR or primary prospective study |
| Scheer et al. 2014270 | Not dermatology study: sympathectomy |
| Schestatsky et al. 2009496 | Not dermatology study: sympathectomy |
| Scholes et al. 1978497 | Not relevant intervention (aluminium chloride) |
| Sciuchetti et al. 2008498 | Not dermatology study: sympathectomy |
| Shalaby et al. 2012330 | Not dermatology study: sympathectomy |
| Sharpe et al. 2013222 | Not a SR or primary prospective study |
| Shen et al. 1990499 | Not relevant intervention (aluminium chloride iontophoresis vs. tap water) |
| Shi et al. 2015331 | Not dermatology study: sympathectomy |
| Simonyi et al. 2010500 | Not primary hyperhidrosis |
| Simonyi et al. 2010303 | Not a SR or primary prospective study |
| Simonyi et al. 2011304 | Not a SR or primary prospective study |
| Solish et al. 200712 | Not a SR or primary prospective study |
| Solish 2008501 | Not a SR or primary prospective study |
| Stefaniak et al. 2009502 | Not dermatology study: sympathectomy |
| Stefaniak and Ćwigoń 2013503 | Not dermatology study: sympathectomy |
| Stefaniak and Ćwigoń 2013504 | Not dermatology study: sympathectomy |
| Steiner et al. 2007332 | Not dermatology study: sympathectomy |
| Streker et al. 2010505 | Not relevant intervention (aluminium chloride) |
| Streker et al. 2012506 | Not relevant intervention (aluminium chloride) |
| Strutton et al. 2004226 | No intervention |
| Suh et al. 2014507 | Not a SR or primary prospective study |
| Swaile et al. 2012508 | Not primary hyperhidrosis |
| Swinehart 2000509 | Not a SR or primary prospective study |
| Tan and Solish 2002263 | Not a SR or primary prospective study |
| Tang et al. 2013510 | Not dermatology study: sympathectomy |
| Teivelis et al. 2014253 | Not a SR or primary prospective study |
| Toolabi et al. 2015511 | Not dermatology study: sympathectomy |
| Umezawa et al. 2011512 | Not dermatology study: sympathectomy |
| Ureña et al. 2009513 | Not a SR or primary prospective study |
| Van Schil 2005514 | Not dermatology study: sympathectomy |
| Vazquez et al. 2011305 | Not dermatology study: sympathectomy |
| Vorkamp et al. 2010515 | Not a SR or primary prospective study |
| Wein et al. 2010516 | Not primary hyperhidrosis |
| Weiss et al. 2010517 | Not dermatology study: sympathectomy |
| Wollina et al. 2002146 | Not relevant intervention (comparing different doses of BTX) |
| Wollina and Konrad 2004518 | Not a SR or primary prospective study |
| Wollina et al. 200820 | Not a SR or primary prospective study |
| Wolosker et al. 2007519 | Not dermatology study: sympathectomy |
| Wolosker et al. 2010244 | Not dermatology study: sympathectomy |
| Wolosker et al. 2010234 | Not dermatology study: sympathectomy |
| Wolosker et al. 2012252 | Not dermatology study: sympathectomy |
| Wolosker et al. 2013254 | Not a SR or primary prospective study |
| Wolosker et al. 2013243 | Not dermatology study: sympathectomy |
| Wolosker et al. 2014237 | Not a SR or primary prospective study |
| Wolosker et al. 2015255 | Duplicate report of Wolosker et al. 201567 |
| Woolery-Lloyd and Valins 2009520 | Not a SR or primary prospective study |
| Woolery-Lloyd and Valins 2009521 | Not a SR or primary prospective study |
| Wörle et al. 2007522 | Not a SR or primary prospective study |
| Xiao et al. 2015333 | Not dermatology study: sympathectomy |
| Yanagishita et al. 2012523 | Not relevant intervention (aluminium chloride) |
| Yazbek et al. 2005235 | Not dermatology study: sympathectomy |
| Yazbek et al. 2009236 | Not dermatology study: sympathectomy |
| Young et al. 2003298 | Not dermatology study: sympathectomy |
| Youssef and Soliman 2015524 | Not dermatology study: sympathectomy |
| Yuncu et al. 2013212 | Not dermatology study: sympathectomy |
| Zaba et al. 2013525 | Not relevant comparator (aluminium chloride and sodium chloride) |
| Zackrisson et al. 2008526 | Not relevant intervention (comparing different doses of BTX) |
