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Westwood M, Ramaekers B, Lang S, et al. ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis. Southampton (UK): NIHR Journals Library; 2016 Sep. (Health Technology Assessment, No. 20.67.)
ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis.
Show detailsStudy details | Allergy type | Secondary or tertiary care? | Intervention | Reference | Outcome | Reason for exclusion and comments |
---|---|---|---|---|---|---|
Ackerbauer 201595 | Food | Yes | ImmunoCAP ISAC 112 | Other | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Acosta Rivera 201296 | Food | Yes | ImmunoCAP ISAC 103 | SPT | No relevant outcomes | Insufficient information for accuracy |
Alessandri 201197 | Food | Yes | ImmunoCAP ISAC 103 | OFC | No relevant outcomes | Insufficient information for accuracy |
Alonso 201498 | Food | ImmunoCAP ISAC 112 | Other | No relevant outcomes | Method of diagnosis not adequately reported; insufficient information for accuracy | |
Alvarado 201399 | Food | Yes | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Antonicelli 2014100 | Food | Unclear | Other | Other | No relevant outcomes | Microarray and reference standard not specified and no relevant outcomes |
Araujo 2012101 | Pollen | Unclear | ImmunoCAP ISAC other | Other | No relevant outcomes | Unspecified version ISAC, diagnosis according to Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines; insufficient information for accuracy |
Asero 2014102 | Pollen | Unclear | Other | NA | No relevant outcomes | Not ISAC or Microtest |
Bauermeister 2009103 | Food | Unclear | Other | NA | No relevant outcomes | ImmunoCAP® 250 – not ISAC or Microtest |
Berneder 2013104 | Food | Unclear | ImmunoCAP ISAC 112 | NA | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Blankestijn 2014105 | Yes | ImmunoCAP ISAC other | NA | No relevant outcomes | Unspecified version ISAC, prevalence only | |
Bokanovic 2013106 | Pollen | Yes | ImmunoCAP ISAC 103 | SPT | Accuracy only | Comparative accuracy: whole panel ISAC vs. sIgE vs. inhaled challenge. Some patients tested with ISAC 112. However, sIgE were reported as measured with ImmunoCAP component assays and ISAC, and accuracy data appeared to relate to the component measured rather than the test (i.e. included participants could have been tested using either method) |
Bonini 2010107 | Other | Unclear | ImmunoCAP ISAC 103 | SPT | No relevant outcomes | Insufficient information for accuracy |
Bonini 2010108 | Other | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Bonini 2012109 | Other | Yes | ImmunoCAP ISAC 103 | NA | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Brans 2012110 | Food | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Concordance only, FEIA vs. single IgE derived from ISAC Comparison of levels of sIgE against omega-5-gliadin, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Cabrera-Freitag 2011111 | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | Technical reproducibility data only | |
Caimmi 2011112 | Food | ImmunoCAP ISAC other | SPT | No relevant outcomes | Unspecified version ISAC, insufficient information for accuracy or concordance | |
Caimmi 2011113 | Other | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Unspecified version ISAC, insufficient information for concordance or accuracy |
Caimmi 2013114 | Other | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Carter 2012115 | Other | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Cavagni 2009116 | Food | Unclear | ImmunoCAP ISAC 89 | OFC | No relevant outcomes | Insufficient information for accuracy |
Cavagni 2010117 | Food | Unclear | ImmunoCAP ISAC 89 | OFC | No relevant outcomes | Insufficient information for accuracy |
Chambel 2011118 | Pollen | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Unspecified version ISAC; insufficient information for accuracy or concordance |
Chambel 2012119 | Pollen | Yes | ImmunoCAP ISAC 103 | SPT | No relevant outcomes | Insufficient information for accuracy; includes only patients with a positive reference standard diagnosis |
Charalambous 2014120 | Other | Yes | ImmunoCAP ISAC other | NA | No relevant outcomes | Exclude ‘Audit’ of clinical records information on patients previously tested with ISAC; no details of test results or their effects on decision-making |
Chevallier 2013121 | Food | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Chia 2013122 | Food | Unclear | Other | Other challenge test | No relevant outcomes | Intervention was unspecified version ISAC or ImmunoCAP; not enough detail for accuracy data |
Cho 2014123 | Pollen | Yes | Other | NA | Concordance only | No relevant outcomes Comparison of positive rates between SPT, AdvanSure and ImmunoCAP sIgE |
Choi 2014124 | Other | Yes | ImmunoCAP ISAC other | SPTs | No relevant outcomes | Unspecified version ISAC; insufficient information for patient level accuracy |
Choi 2014125 | Other | Unclear | ImmunoCAP ISAC other | SPTs | No relevant outcomes | Unspecified version ISAC; insufficient details for accuracy |
De Amici 2014126 | Other | Unclear | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Comparison with ISAC 103, outcome was described as ‘diagnostic utility’ and ‘therapeutic utility’ scores, but no further details were reported |
De Boer 2012127 | Other | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | Technical reproducibility and limit of detection only, using a single pooled QC sample. Intra-assay and inter-assay variation |
De Boer 2013128 | Other | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
De Boer 2013128 | Food | Yes | ImmunoCAP ISAC 112 | NA | No relevant outcomes | No relevant outcomes |
De Knop 2011129 | Food | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Doyen 2011130 | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | Interference of omalizunab with ISAC and ImmunoCAP | |
Ebo 2010131 | Latex | Yes | ImmunoCAP ISAC 103 | SPT | No relevant outcomes | Insufficient information for accuracy |
Ebo 2010132 | Pollen | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Eller 2013133 | Food | Yes | Other | SPT | Accuracy only | ImmuoCAP sIgE only |
Fernandez 2011134 | Pollen | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Unspecified version ISAC, insufficient information for concordance |
Flores 2014135 | Pollen | Yes | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Fung 2012136 | Food | Unclear | ImmunoCAP ISAC other | Other | No relevant outcomes | No relevant outcomes |
Gadisseur 2009137 | Other | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | Insufficient information for concordance or accuracy |
Gadisseur 2011138 | Other | Unclear | ImmunoCAP ISAC 103 | NA | Concordance only | No relevant outcomes Reports agreement on allergen source between specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Gadisseur 2011138 | Other | Yes | ImmunoCAP ISAC 103 | NA | Concordance only | No relevant outcomes Reports agreement between sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Gadisseur 2012139 | Food | Unclear | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Refers to additional information provided by ISAC, but no details given |
Garriga Baraut 2010140 | Pollen | Unclear | ImmunoCAP ISAC other | SPT | No relevant outcomes | Unspecified version ISAC; insufficient information for accuracy |
Goikoetxea 2013141 | No | Other | NA | No relevant outcomes | Review article | |
Goikoetxea 2015142 | Yes | ImmunoCAP ISAC 112 | NA | No relevant outcomes | No relevant outcomes | |
Hermansson 201260 | Pollen | ImmunoCAP ISAC other | Other | Economics only | No relevant outcomes | |
Hoffmann 2014143 | Pollen | Unclear | Other | NA | No relevant outcomes | Intervention was SIT: use of ISAC and IgE/IgG4 to measure response to SIT |
Hong 2011144 | Food | Unclear | ImmunoCAP ISAC 103 | Other | No relevant outcomes | Insufficient information for accuracy |
Hong 2012145 | Food | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Javaloyes 2012146 | Food | Yes | ImmunoCAP ISAC 103 | Other | No relevant outcomes | No relevant outcomes |
Jung 2012147 | Pollen | Unclear | ImmunoCAP ISAC other | SPT | No relevant outcomes | Insufficient information for accuracy or concordance and unspecified version of ISAC |
Kattan 2013148 | Food | Yes | ImmunoCAP ISAC 112 | OFC | No relevant outcomes | Insufficient information for accuracy |
Kattan 2014149 | Food | Yes | ImmunoCAP ISAC 112 | OFC | Accuracy only | Accuracy of components of ISAC for peanut allergy only (no comparative data) |
Kim 2015150 | Pollen | Unclear | ImmunoCAP ISAC other | SPT | No relevant outcomes | Insufficient detail on accuracy data |
Klemans 2013151 | Food | Yes | ImmunoCAP ISAC 103 | SPT | No relevant outcomes | No relevant outcomes, incomplete accuracy data |
Klemans 2014152 | Food | Yes | ImmunoCAP ISAC 112 | OFC | Accuracy only | ISAC only, no comparative accuracy data |
Konradsen 2015153 | Other | Unclear | Microtest | NA | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by Microtest, single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the three methods |
Lee 2013154 | Food | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Liso 2011155 | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Experimental ISAC with omalizumab added and no relevant outcomes | |
Liu 2011156 | Food | Unclear | ImmunoCAP ISAC other | OFC | Accuracy only | Accuracy reported for the allergen component (measured by a variety of methods). Data reported only for ISAC; no comparative accuracy data |
Lizaso 2011157 | Pollen | Yes | ImmunoCAP ISAC 89 | NA | Concordance only | No relevant outcomes Reports percentage agreement between single ImmunoCAP sIgE, ImmunoCAP ISAC 89, and an Avida-Centaur component resolved assay, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Lohman 2013158 | Other | NA | No relevant outcomes | Not ISAC, development of a microarray | ||
Luengo 2011159 | Food | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | Insufficient outcome information |
Mailhol 2013160 | Unclear | ImmunoCAP ISAC 112 | NA | No relevant outcomes | No relevant outcomes | |
Martinez-Aranguren 2013161 | Unclear | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Technical reproducibility only, wrong comparator | |
Martinez-Aranguren 2014162 | Other | Unclear | ImmunoCAP ISAC 112 | NA | Concordance only | No relevant outcomes Reports agreement on sensitisations between single ImmunoCAP sIgE, ImmunoCAP ISAC112 and SPT, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Martinez-Aranguren 2014163 | Food | Yes | ImmunoCAP ISAC 112 | SPT | Accuracy only | ISAC only, no comparative accuracy |
Martinez-Aranguren 2014164 | Other | Yes | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Technical data, assay reproducibility only |
Mascialino 201359 | Pollen | Yes | ImmunoCAP ISAC other | NA | Economics only | No relevant outcomes |
Mascialino 201358 | Pollen | Economics only | No relevant outcomes | |||
Melioli 2011165 | Pollen | Yes | ImmunoCAP ISAC 103 | NA | Concordance only | No relevant outcomes Reports percentage positive agreement between single ImmunoCAP sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Microtest DX 2014166 | Other | Unclear | Microtest | NA | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by Microtest, single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the three methods |
Murng 2011167 | Other | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Insufficient details of outcomes reported, unspecified version ISAC |
Murng 2011168 | Food | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Insufficient outcome information |
Nanda 2015169 | Food | Unclear | Other | NA | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and an unspecified version of ImmunoCAP ISAC, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Nicaise-Rolland 2010170 | Unclear | ImmunoCAP ISAC 103 | Other | No relevant outcomes | Insufficient information for accuracy | |
Nicolaou 2010171 | Food | Other | NA | No relevant outcomes | Not ISAC or Microtest | |
Nicolaou 2010171 | Food | Yes | Other | NA | No relevant outcomes | Not ISAC or Microtest |
Nystrand 2012172 | Unclear | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Technical reproducibility and limit of detection only | |
Olivieri 2010 173 | Food | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Olivieri 2013174 | Food | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Onell 2012175 | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes | |
Ott 2010176 | Other | Unclear | Other | NA | No relevant outcomes | No relevant outcomes, unspecified microarray |
Paes 2010177 | Food | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Palomba 2013178 | Other | Unclear | Microtest | NA | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by Microtest and single ImmunoCAP sIgE, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Palomba 2014179 | Other | Unclear | Microtest | NA | No relevant outcomes | Concordance between Microtest and an unspecified commercially available system, insufficient detail reported |
Pascal 201693 | Food | Yes | ImmunoCAP ISAC 112 | SPT, sIgE | Accuracy only | No comparison results for sIgE or SPT |
Passalacqua 201352 | Other | Unclear | Other | NA | Treatment change | Insufficient outcome details, but abstract refers to treatment change |
Patelis 2012180 | Pollen | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Pedrosa 201292 | Food | Yes | ImmunoCAP ISAC 103 | Other | Accuracy only | Accuracy of various components on ISAC only (no comparison with other index tests, e.g. sIgE or SPT) |
Pomponi 2013181 | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | Autoimmune disease | |
Raulf 2014182 | No | Other | NA | No relevant outcomes | Review article | |
Röckmann 2014183 | Food | Yes | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Rodriguez-Ferran 201161 | Unclear | Other | NA | No relevant outcomes | Review article | |
Romano 2012184 | Food | Unclear | Other | Other | No relevant outcomes | No relevant outcomes |
Sanchez-Lopez 2013185 | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Unclear whether results were derived from an unspecified version of ISAC or UniCAP sIgE | |
Santos 2011186 | Pollen | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Santosa 2015187 | Other | Yes | ImmunoCAP ISAC 112 | NA | No relevant outcomes | No relevant outcomes |
Sanz 201094 | Pollen | Unclear | ImmunoCAP ISAC 103 | SPT | Accuracy only | Accuracy of various components on ISAC only (no comparison with other index tests, e.g. sIgE or SPT) |
Sastre 2014188 | Pollen | Yes | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Scala 2011189 | Food | Unclear | ImmunoCAP ISAC 103 | Other | No relevant outcomes | Method of diagnosis not specified, insufficient information for accuracy |
Scala 2011190 | Other | Unclear | ImmunoCAP ISAC 103 | NA | No relevant outcomes | No relevant outcomes |
Schuler 2013191 | Latex | Yes | Other | SPT | No relevant outcomes | Intervention either ImmunoCAP sIgE or ISAC |
Seyfarth 2011192 | Latex | Unclear | ImmunoCAP ISAC 103 | Other | No relevant outcomes | Partial accuracy only, no reference standard defined, non-clinical spiked sample |
Seyfarth 2011192 | Latex | Unclear | ImmunoCAP ISAC other | Other | No relevant outcomes | Partial accuracy only, no reference standard defined, non-clinical spiked sample |
Seyfarth 2011193 | Latex | Unclear | ImmunoCAP ISAC 103 | Other | No relevant outcomes | Partial accuracy only, no reference standard defined, non-clinical spiked sample |
Seyfarth 2014194 | Latex | Yes | ImmunoCAP ISAC 103 | SPT | No relevant outcomes | Partial accuracy only, non-clinical spiked sample |
Shibata 2014195 | Food | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Sousa 2009196 | Pollen | Unclear | ImmunoCAP ISAC other | SPT | Accuracy only | ISAC only, no comparative accuracy |
Stringari 201451 | Pollen | Yes | Other | NA | Clinical | Not ISAC or Microtest, ImmunoCAP FEIA |
Tolkki 2013197 | Food | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Tolkki 2013198 | Food | Yes | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Tripathi 2012199 | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | Eosinophilic esophagitis and no relevant outcomes | |
Tripathi 2014200 | Food | Unclear | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Eosinophilic esophagitis and no relevant outcomes |
Tripathi 2014201 | Food | ImmunoCAP ISAC 112 | NA | No relevant outcomes | Mixed population | |
Uriarte 2013202 | Other | Unclear | Other | NA | No relevant outcomes | Intervention was sIgE ImmunoCAP or ISAC |
Vitte 2014203 | Other | Unclear | ImmunoCAP ISAC other | NA | No relevant outcomes | No relevant outcomes |
Weimann 2011204 | Unclear | ImmunoCAP ISAC other | Other | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and an unspecified version of ImmunoCAP ISAC, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods | |
Williams205 | Other | Yes | Microtest | Other | Concordance only | No relevant outcomes Correlation of specific serum IgE levels measured by Microtest and single ImmunoCAP sIgE, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods |
Yadzir 2014206 | Other | Yes | ImmunoCAP ISAC 112 | SPT | No relevant outcomes | Insufficient information for accuracy |
Young 2012207 | Other | Yes | ImmunoCAP ISAC 112 | NA | No relevant outcomes | No data |
ARIA, Allergic Rhinitis and its Impact on Asthma; FEIA, fluoroenzyme immunoassay; NA, not applicable; QC, quality control.
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