U.S. flag

An official website of the United States government

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Westwood M, Ramaekers B, Lang S, et al. ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis. Southampton (UK): NIHR Journals Library; 2016 Sep. (Health Technology Assessment, No. 20.67.)

Cover of ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis

ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis.

Show details

Appendix 3Table of excluded studies with rationale

Study detailsAllergy typeSecondary or tertiary care?InterventionReferenceOutcomeReason for exclusion and comments
Ackerbauer 201595FoodYesImmunoCAP ISAC 112OtherConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Acosta Rivera 201296FoodYesImmunoCAP ISAC 103SPTNo relevant outcomesInsufficient information for accuracy
Alessandri 201197FoodYesImmunoCAP ISAC 103OFCNo relevant outcomesInsufficient information for accuracy
Alonso 201498FoodImmunoCAP ISAC 112OtherNo relevant outcomesMethod of diagnosis not adequately reported; insufficient information for accuracy
Alvarado 201399FoodYesImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Antonicelli 2014100FoodUnclearOtherOtherNo relevant outcomesMicroarray and reference standard not specified and no relevant outcomes
Araujo 2012101PollenUnclearImmunoCAP ISAC otherOtherNo relevant outcomesUnspecified version ISAC, diagnosis according to Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines; insufficient information for accuracy
Asero 2014102PollenUnclearOtherNANo relevant outcomesNot ISAC or Microtest
Bauermeister 2009103FoodUnclearOtherNANo relevant outcomesImmunoCAP® 250 – not ISAC or Microtest
Berneder 2013104FoodUnclearImmunoCAP ISAC 112NAConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Blankestijn 2014105YesImmunoCAP ISAC otherNANo relevant outcomesUnspecified version ISAC, prevalence only
Bokanovic 2013106PollenYesImmunoCAP ISAC 103SPTAccuracy onlyComparative accuracy: whole panel ISAC vs. sIgE vs. inhaled challenge. Some patients tested with ISAC 112. However, sIgE were reported as measured with ImmunoCAP component assays and ISAC, and accuracy data appeared to relate to the component measured rather than the test (i.e. included participants could have been tested using either method)
Bonini 2010107OtherUnclearImmunoCAP ISAC 103SPTNo relevant outcomesInsufficient information for accuracy
Bonini 2010108OtherUnclearImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Bonini 2012109OtherYesImmunoCAP ISAC 103NAConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Brans 2012110FoodUnclearImmunoCAP ISAC otherNANo relevant outcomesConcordance only, FEIA vs. single IgE derived from ISAC
Comparison of levels of sIgE against omega-5-gliadin, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Cabrera-Freitag 2011111YesImmunoCAP ISAC 103NANo relevant outcomesTechnical reproducibility data only
Caimmi 2011112FoodImmunoCAP ISAC otherSPTNo relevant outcomesUnspecified version ISAC, insufficient information for accuracy or concordance
Caimmi 2011113OtherUnclearImmunoCAP ISAC otherNANo relevant outcomesUnspecified version ISAC, insufficient information for concordance or accuracy
Caimmi 2013114OtherUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Carter 2012115OtherYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Cavagni 2009116FoodUnclearImmunoCAP ISAC 89OFCNo relevant outcomesInsufficient information for accuracy
Cavagni 2010117FoodUnclearImmunoCAP ISAC 89OFCNo relevant outcomesInsufficient information for accuracy
Chambel 2011118PollenUnclearImmunoCAP ISAC otherNANo relevant outcomesUnspecified version ISAC; insufficient information for accuracy or concordance
Chambel 2012119PollenYesImmunoCAP ISAC 103SPTNo relevant outcomesInsufficient information for accuracy; includes only patients with a positive reference standard diagnosis
Charalambous 2014120OtherYesImmunoCAP ISAC otherNANo relevant outcomesExclude
‘Audit’ of clinical records information on patients previously tested with ISAC; no details of test results or their effects on decision-making
Chevallier 2013121FoodYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Chia 2013122FoodUnclearOtherOther challenge testNo relevant outcomesIntervention was unspecified version ISAC or ImmunoCAP; not enough detail for accuracy data
Cho 2014123PollenYesOtherNAConcordance onlyNo relevant outcomes
Comparison of positive rates between SPT, AdvanSure and ImmunoCAP sIgE
Choi 2014124OtherYesImmunoCAP ISAC otherSPTsNo relevant outcomesUnspecified version ISAC; insufficient information for patient level accuracy
Choi 2014125OtherUnclearImmunoCAP ISAC otherSPTsNo relevant outcomesUnspecified version ISAC; insufficient details for accuracy
De Amici 2014126OtherUnclearImmunoCAP ISAC 112NANo relevant outcomesComparison with ISAC 103, outcome was described as ‘diagnostic utility’ and ‘therapeutic utility’ scores, but no further details were reported
De Boer 2012127OtherUnclearImmunoCAP ISAC 103NANo relevant outcomesTechnical reproducibility and limit of detection only, using a single pooled QC sample. Intra-assay and inter-assay variation
De Boer 2013128OtherUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
De Boer 2013128FoodYesImmunoCAP ISAC 112NANo relevant outcomesNo relevant outcomes
De Knop 2011129FoodYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Doyen 2011130UnclearImmunoCAP ISAC 103NANo relevant outcomesInterference of omalizunab with ISAC and ImmunoCAP
Ebo 2010131LatexYesImmunoCAP ISAC 103SPTNo relevant outcomesInsufficient information for accuracy
Ebo 2010132PollenYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Eller 2013133FoodYesOtherSPTAccuracy onlyImmuoCAP sIgE only
Fernandez 2011134PollenUnclearImmunoCAP ISAC otherNANo relevant outcomesUnspecified version ISAC, insufficient information for concordance
Flores 2014135PollenYesImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Fung 2012136FoodUnclearImmunoCAP ISAC otherOtherNo relevant outcomesNo relevant outcomes
Gadisseur 2009137OtherUnclearImmunoCAP ISAC 103NANo relevant outcomesInsufficient information for concordance or accuracy
Gadisseur 2011138OtherUnclearImmunoCAP ISAC 103NAConcordance onlyNo relevant outcomes
Reports agreement on allergen source between specific serum IgE levels measured by single ImmunoCAP sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Gadisseur 2011138OtherYesImmunoCAP ISAC 103NAConcordance onlyNo relevant outcomes
Reports agreement between sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Gadisseur 2012139FoodUnclearImmunoCAP ISAC 112NANo relevant outcomesRefers to additional information provided by ISAC, but no details given
Garriga Baraut 2010140PollenUnclearImmunoCAP ISAC otherSPTNo relevant outcomesUnspecified version ISAC; insufficient information for accuracy
Goikoetxea 2013141NoOtherNANo relevant outcomesReview article
Goikoetxea 2015142YesImmunoCAP ISAC 112NANo relevant outcomesNo relevant outcomes
Hermansson 201260PollenImmunoCAP ISAC otherOtherEconomics onlyNo relevant outcomes
Hoffmann 2014143PollenUnclearOtherNANo relevant outcomesIntervention was SIT: use of ISAC and IgE/IgG4 to measure response to SIT
Hong 2011144FoodUnclearImmunoCAP ISAC 103OtherNo relevant outcomesInsufficient information for accuracy
Hong 2012145FoodYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Javaloyes 2012146FoodYesImmunoCAP ISAC 103OtherNo relevant outcomesNo relevant outcomes
Jung 2012147PollenUnclearImmunoCAP ISAC otherSPTNo relevant outcomesInsufficient information for accuracy or concordance and unspecified version of ISAC
Kattan 2013148FoodYesImmunoCAP ISAC 112OFCNo relevant outcomesInsufficient information for accuracy
Kattan 2014149FoodYesImmunoCAP ISAC 112OFCAccuracy onlyAccuracy of components of ISAC for peanut allergy only (no comparative data)
Kim 2015150PollenUnclearImmunoCAP ISAC otherSPTNo relevant outcomesInsufficient detail on accuracy data
Klemans 2013151FoodYesImmunoCAP ISAC 103SPTNo relevant outcomesNo relevant outcomes, incomplete accuracy data
Klemans 2014152FoodYesImmunoCAP ISAC 112OFCAccuracy onlyISAC only, no comparative accuracy data
Konradsen 2015153OtherUnclearMicrotestNAConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by Microtest, single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the three methods
Lee 2013154FoodUnclearImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Liso 2011155UnclearImmunoCAP ISAC otherNANo relevant outcomesExperimental ISAC with omalizumab added and no relevant outcomes
Liu 2011156FoodUnclearImmunoCAP ISAC otherOFCAccuracy onlyAccuracy reported for the allergen component (measured by a variety of methods). Data reported only for ISAC; no comparative accuracy data
Lizaso 2011157PollenYesImmunoCAP ISAC 89NAConcordance onlyNo relevant outcomes
Reports percentage agreement between single ImmunoCAP sIgE, ImmunoCAP ISAC 89, and an Avida-Centaur component resolved assay, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Lohman 2013158OtherNANo relevant outcomesNot ISAC, development of a microarray
Luengo 2011159FoodUnclearImmunoCAP ISAC 103NANo relevant outcomesInsufficient outcome information
Mailhol 2013160UnclearImmunoCAP ISAC 112NANo relevant outcomesNo relevant outcomes
Martinez-Aranguren 2013161UnclearImmunoCAP ISAC 112NANo relevant outcomesTechnical reproducibility only, wrong comparator
Martinez-Aranguren 2014162OtherUnclearImmunoCAP ISAC 112NAConcordance onlyNo relevant outcomes
Reports agreement on sensitisations between single ImmunoCAP sIgE, ImmunoCAP ISAC112 and SPT, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Martinez-Aranguren 2014163FoodYesImmunoCAP ISAC 112SPTAccuracy onlyISAC only, no comparative accuracy
Martinez-Aranguren 2014164OtherYesImmunoCAP ISAC 112NANo relevant outcomesTechnical data, assay reproducibility only
Mascialino 201359PollenYesImmunoCAP ISAC otherNAEconomics onlyNo relevant outcomes
Mascialino 201358PollenEconomics onlyNo relevant outcomes
Melioli 2011165PollenYesImmunoCAP ISAC 103NAConcordance onlyNo relevant outcomes
Reports percentage positive agreement between single ImmunoCAP sIgE and ImmunoCAP ISAC 103, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Microtest DX 2014166OtherUnclearMicrotestNAConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by Microtest, single ImmunoCAP sIgE and ImmunoCAP ISAC 112, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the three methods
Murng 2011167OtherUnclearImmunoCAP ISAC otherNANo relevant outcomesInsufficient details of outcomes reported, unspecified version ISAC
Murng 2011168FoodUnclearImmunoCAP ISAC otherNANo relevant outcomesInsufficient outcome information
Nanda 2015169FoodUnclearOtherNAConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and an unspecified version of ImmunoCAP ISAC, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Nicaise-Rolland 2010170UnclearImmunoCAP ISAC 103OtherNo relevant outcomesInsufficient information for accuracy
Nicolaou 2010171FoodOtherNANo relevant outcomesNot ISAC or Microtest
Nicolaou 2010171FoodYesOtherNANo relevant outcomesNot ISAC or Microtest
Nystrand 2012172UnclearImmunoCAP ISAC 112NANo relevant outcomesTechnical reproducibility and limit of detection only
Olivieri 2010 173FoodUnclearImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Olivieri 2013174FoodYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Onell 2012175YesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Ott 2010176OtherUnclearOtherNANo relevant outcomesNo relevant outcomes, unspecified microarray
Paes 2010177FoodUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Palomba 2013178OtherUnclearMicrotestNAConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by Microtest and single ImmunoCAP sIgE, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Palomba 2014179OtherUnclearMicrotestNANo relevant outcomesConcordance between Microtest and an unspecified commercially available system, insufficient detail reported
Pascal 201693FoodYesImmunoCAP ISAC 112SPT, sIgEAccuracy onlyNo comparison results for sIgE or SPT
Passalacqua 201352OtherUnclearOtherNATreatment changeInsufficient outcome details, but abstract refers to treatment change
Patelis 2012180PollenUnclearImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Pedrosa 201292FoodYesImmunoCAP ISAC 103OtherAccuracy onlyAccuracy of various components on ISAC only (no comparison with other index tests, e.g. sIgE or SPT)
Pomponi 2013181YesImmunoCAP ISAC 103NANo relevant outcomesAutoimmune disease
Raulf 2014182NoOtherNANo relevant outcomesReview article
Röckmann 2014183FoodYesImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Rodriguez-Ferran 201161UnclearOtherNANo relevant outcomesReview article
Romano 2012184FoodUnclearOtherOtherNo relevant outcomesNo relevant outcomes
Sanchez-Lopez 2013185UnclearImmunoCAP ISAC otherNANo relevant outcomesUnclear whether results were derived from an unspecified version of ISAC or UniCAP sIgE
Santos 2011186PollenUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Santosa 2015187OtherYesImmunoCAP ISAC 112NANo relevant outcomesNo relevant outcomes
Sanz 201094PollenUnclearImmunoCAP ISAC 103SPTAccuracy onlyAccuracy of various components on ISAC only (no comparison with other index tests, e.g. sIgE or SPT)
Sastre 2014188PollenYesImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Scala 2011189FoodUnclearImmunoCAP ISAC 103OtherNo relevant outcomesMethod of diagnosis not specified, insufficient information for accuracy
Scala 2011190OtherUnclearImmunoCAP ISAC 103NANo relevant outcomesNo relevant outcomes
Schuler 2013191LatexYesOtherSPTNo relevant outcomesIntervention either ImmunoCAP sIgE or ISAC
Seyfarth 2011192LatexUnclearImmunoCAP ISAC 103OtherNo relevant outcomesPartial accuracy only, no reference standard defined, non-clinical spiked sample
Seyfarth 2011192LatexUnclearImmunoCAP ISAC otherOtherNo relevant outcomesPartial accuracy only, no reference standard defined, non-clinical spiked sample
Seyfarth 2011193LatexUnclearImmunoCAP ISAC 103OtherNo relevant outcomesPartial accuracy only, no reference standard defined, non-clinical spiked sample
Seyfarth 2014194LatexYesImmunoCAP ISAC 103SPTNo relevant outcomesPartial accuracy only, non-clinical spiked sample
Shibata 2014195FoodUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Sousa 2009196PollenUnclearImmunoCAP ISAC otherSPTAccuracy onlyISAC only, no comparative accuracy
Stringari 201451PollenYesOtherNAClinicalNot ISAC or Microtest, ImmunoCAP FEIA
Tolkki 2013197FoodUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Tolkki 2013198FoodYesImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Tripathi 2012199UnclearImmunoCAP ISAC otherNANo relevant outcomesEosinophilic esophagitis and no relevant outcomes
Tripathi 2014200FoodUnclearImmunoCAP ISAC 112NANo relevant outcomesEosinophilic esophagitis and no relevant outcomes
Tripathi 2014201FoodImmunoCAP ISAC 112NANo relevant outcomesMixed population
Uriarte 2013202OtherUnclearOtherNANo relevant outcomesIntervention was sIgE ImmunoCAP or ISAC
Vitte 2014203OtherUnclearImmunoCAP ISAC otherNANo relevant outcomesNo relevant outcomes
Weimann 2011204UnclearImmunoCAP ISAC otherOtherConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by single ImmunoCAP sIgE and an unspecified version of ImmunoCAP ISAC, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Williams205OtherYesMicrotestOtherConcordance onlyNo relevant outcomes
Correlation of specific serum IgE levels measured by Microtest and single ImmunoCAP sIgE, but insufficient data to compare diagnostic performance (e.g. sensitivity and specificity) of the two methods
Yadzir 2014206OtherYesImmunoCAP ISAC 112SPTNo relevant outcomesInsufficient information for accuracy
Young 2012207OtherYesImmunoCAP ISAC 112NANo relevant outcomesNo data

ARIA, Allergic Rhinitis and its Impact on Asthma; FEIA, fluoroenzyme immunoassay; NA, not applicable; QC, quality control.

Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Westwood et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK384700
Contents

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (1.4M)

Other titles in this collection

Recent Activity

ClearTurn OffTurn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...