We thank all the patients who agreed to enter the study, the investigators who contributed to the trial and the Dementia and Neurodegenerative Disease (DeNDRoN) Clinical Research Network for their support with recruitment. We also thank the Service Users Group for their help in designing the trial. The PDQ-39 questionnaire was developed by Crispin Jenkinson, Ray Fitzpatrick and Viv Peto in 1993, who have asserted their moral rights in it, and the copyright, which is owned by Isis Innovation Limited. The questionnaire was first published in 1995 in the journal Quality of Life Research. No part of this questionnaire may be reproduced without the prior written consent of Isis Innovation Limited.
Participating centres and PD REHAB collaborative group members
* indicates current principal investigator at that centre.
Aberdeen Royal Infirmary, Aberdeen (5)
S Armour, C Counsell,* C Harris, C Knight, V Leslie and M Ord.
Central Middlesex Hospital, London (24)
R Bharmal, N Idris, A Lacey, S Molloy,* C Mummery, M Patel, C Sequeira, G Sharma and E White.
City Hospital, Birmingham (38)
A Billingham, K Blachford, C Clarke,* C Coley, T Doxsey, C Holdsworth, C Kanakaratna, F Kinney, D Nicholl, S Purkis, F Siddiqui and C Street.
Cumberland Infirmary, Carlisle (13)
B Bishop, J Bowyer, J George,* A Hampson and V Marshall.
Darlington Memorial Hospital, Darlington (21)
L Alderton, S Ayirookuzhi, S Carney, P Carr, L Cochrane, M Corr, L Curran, C Deacon, S Hilton, A Martin, M Omole, R Prescott,* A Rose and H Watson.
Dorset County Hospital, Dorchester (21)
M Baker, S Breakspear, B Burgess, S Caddy, S Carr, S Chaplin, C Coleman, R Gregory,* A Jones, L O’Shea, H Read, S Richardson and L Villanueva.
Eryri Hospital, Caernarfon (9)
J Hindle, P Ohri,* A Owen, C Pritchard, E Roberts and F Williams.
Fairfield General Hospital, Bury (24)
A Ansari, K Birtwell, J Brooke, L Craven, A Drogan, E Hill, E Johnson, E Oughton, J Raw,* C Thistlewaite and T Wijethunge.
Gloucestershire Royal Hospital, Gloucester (27)
K Bird, P Brown, F Clayton-Smith, F Davis, H Dix, P Fletcher,* E Folkes, V Hardwick, K Harrison, K Keene, P Medcalf, P Morrish, M Silva, G Thistlewood and H Wilson.
Lincolnshire Hospitals, Lincoln and Grantham (52)
D Boyer, L Crisp, A Kirjazovas, H Lister, A Macedonska, E Munyonga, R Norton, C Rees, B Sharrack, J Sharma,* K Shelbourn, S Strickland and E Ward.
Harrogate District Hospital, Harrogate (11)
P Bagot, G Burton, A Gillespie, E Jackson, S Smith, G Wihl,* R Worton and J Young.
Hereford County Hospital, Hereford (4)
M Cottrell, J Dalziel, C Evans, D Kent, P Matheson and E Wales.*
Hull Royal Infirmary, Hull (5)
J Cook, J Curran, A Ming* and D Parker.
Leicester General Hospital, Leicester (9)
D Bovington, C Brownson, K Castle, N Clague, S Forrest, N Lavin, J Lindsay, N Lo,* J Lokat, R MacDonald, K MacSwiney, S Seaman and J Taylor.
Macclesfield District General Hospital, Macclesfield (25)
K Bullivant, A Crosby, R Graba, E Oughton, S Raybould, D Rowarth, H Rooney, M Silverdale,* C Vandor, H Vanek and T Wright.
Mount Gould Hospital, Plymouth (19)
H Brookes, S Edwards, B Dingle, M Holme, K Jones, G Kendall, S Mahadik,* F Murphy, K Stocker, M-J Trimmer and M Visick.
Musgrove Park Hospital, Taunton (31)
R Chorley, S Cooper,* A Dawton, C Henley, J Homan, D Sharratt and J Vassalli.
Newmarket Community Hospital, Newmarket (8)
G Calderon, L Canovas, M Glass, S Hooley, W Houghton, A Jackson, G Lennox,* A South and T Ward.
Norfolk & Norwich University Hospital, Norwich (30)
A Clark, P Crosby, C Herrington, A Hursey, C Garrett, K Goddard, L Reynolds, J Taylor, J West and P Worth.*
North Devon District Hospital, Barnstaple (10)
G Harper,* S Hilsdon, T Harrower, S Pike and N Vernon.
Peterborough City Hospital, Peterborough (6)
G Calderon, L Canovas, E Davies, C Farrar, S Guptha,* A Jackson, C Noble and J Sheldrake.
Poole General Hospital, Poole (15)
L Chohra, C Cooper, M Goddard, R Gregory,* G King and V Stone.
Princess of Wales Hospital, Bridgend (20)
L Ebenezer, R Gdesis, C Muller, S Raha,* P Sloan, S Thomson and R Turner.
Queen Alexandra Hospital, Portsmouth (23)
M Chawner, C Delves, C Edwards, C Francis, W Gibb, Z Hemsley,* J Hewitt, E Hoysted, K Lapicki, T Jepp, S Marsh, A McBride, E McNaughton, S Pearce, C Rayner, C Saunders, A Stephenson, B Uwe, J Walker and L Wimshurst.
Royal Blackburn Hospital, Blackburn (24)
J Birt, S Crane, M Hare, C Kenyon, L McToal, P Tidswell,* N Verstraelen and K Ward.
Royal Bournemouth General Hospital, Bournemouth (40)
K Amar,* S Atkins, C Cooper, L du Preez, G Hodges, G King, K Kuhr, T Senyard, C Thompson and B Utting.
Royal Devon & Exeter Hospital, Exeter (65)
C Askham, B Bailey, W Blour, L Butler, F Chanton, C Davies, R Elliott, G Fenwick, D Gladman, K Gormley, F Havlin, T Harrower, J Holman, S Irvine, R James, A-M Jones, D Kendrick, R Lane, T Malone,* V Matthews, T Morris, L Morley, V Pearce, A Potter, K Priestner, A Quthue-Jones, F Robotham, R Sheridan, C Smith, K Smith, A Souster, V Wilkins and A Woodger.
Royal Hampshire County Hospital, Winchester (9)
C Barlow, E Carroll, E Ghazaros, C Gordon,* T McElwaine and H Slater.
Royal Preston Hospital, Preston (24)
J Bimson, J Birt, S Cornall, M Hare, T Majeed,* J Pearson, D Stephenson, R Turner, N Verstraelen and K Ward.
St Helens and Knowsley Hospitals, St Helen (25)
J Abrams,* C Andrew, S Ashley, D Dufay, D Gandecha, A Howman, L Molloy, E Oughton, H Rayner and N Smith.
Salisbury District Hospital, Salisbury (3)
K Grainger, J Lee and J Marigold.*
Southampton General Hospital, Southampton (26)
V Agarwal, L Ashdown, C Carden-Noad, C Dean, C Edwards, G Howard and H Roberts.*
Torbay District General Hospital, Torbay (10)
L Halfhide, A Hall, G Kendall,* P McConkey, P Mercer and K Roberts.
Walton Centre for Neurology & Neurosurgery, Liverpool (41)
S Burns, D Davies, A Deaves, N Hallissey, L Hughes, H McGuinn, AP Moore,* I O’Brien, H O’Heary, N Porter, M Steiger, D Watling, L Webb and L Wyatt.
Weston General Hospital, Weston-super-Mare (18)
S Barber, S Bedford, H Dymond, P Easton, F Henchie, K Powell, R Roberts,* G Saunders, D Simmons and S Whitford.
William Harvey Hospital, Ashford (11)
J Hawkins, A Heller, L Hills, M Jenkinson, M McHenry, N Munro, M Sakel, M Samuel,* N Scoble, K Turner, R Vahid and A Vincent.
Yeovil District Hospital, Yeovil (17)
K Baker, H Brunt, C Buckley, M Jones, K Randall, C Redman, R Rowland-Axe, R Sophia* and R Tonkin.
Contributions of authors
Carl E Clarke (Chief Investigator), Catherine M Sackley, Marion F Walker, Natalie Ives and Keith Wheatley designed the trial.
Carl E Clarke, Catherine M Sackley, Natalie Ives, Keith Wheatley, Smitaa Patel and Caroline E Rick ran the trial and Carl E Clarke recruited patients.
Natalie Ives, Smitaa Patel and Rebecca Woolley performed the interim and final data analyses.
Shihua Zhu, Rebecca Kandiyali and Guiqing Yao performed the health economics analysis.
Carl E Clarke, Catherine M Sackley, Marion F Walker, Natalie Ives, Smitaa Patel, Caroline E Rick, Keith Wheatley and Guiqing Yao interpreted the data and wrote the paper. The authors assume responsibility for the accuracy and completeness of the data and for the overall content and integrity of the paper.
Data Monitoring Committee
Professor G Kwakkel (Chairperson), Professor J Gladman, Dr N Bajaj and Dr L Hiller.
Trial Steering Committee
Professor D Burn (Chairperson), Dr K Breen, Mr H Bridge, Professor H Dawes, Dr D MacMahon, Dr P Ohri, Dr H Roberts and Mrs E Wolstenholme.
Therapy experts group
A Aragon, A Birleson, P Chapman, V Goodwin, A Keene, V Kelly, F Lindop, E Morgan, B Ramaswamy and L Rochester.
Service users group
H Bridge, R Coelho, K Gordon, S Herron-Marx, J Morgan, D Muir Wood, R Norton, R Patel, A Peet, C Sanders, S Shah, J Taylor, G Thorpe and EWK Young,
Publications from PD REHAB
Clarke CE, Patel S, Ives N, Rick CE, Dowling F, Woolley R, et al. Physiotherapy and occupational therapy vs no therapy in mild to moderate Parkinson disease: a randomized clinical trial. JAMA Neurol 2016;73:291–9.
Clarke CE, Patel S, Woolley R, Ives N, Rick CE, Wheatley K, Walker MF, Sackley CM, on behalf of the PD REHAB Collaborative Group. PD REHAB RCT of physio- and occupational therapy in Parkinson’s disease. Association of British Neurologists Annual Conference, Cardiff, UK, May 2014.
Clarke CE, Patel S, Woolley R, Ives N, Rick CE, Wheatley K, Walker MF, Sackley CM, on behalf of the PD REHAB Collaborative Group. PD REHAB: A large pragmatic randomised controlled trial of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease. 18th International Congress of Parkinson’s Disease and Movement Disorders, Stockholm, Sweden, 8–12 June 2014.
Dowling FP, Rick C, Sackley C, Walker M, Ives N, Patel S, et al. Parkinson’s disease REHAB: Randomised controlled trial to study the effectiveness and cost-effectiveness of physiotherapy and occupational therapy for people with PD. 16th International Congress of Parkinson’s Disease and Movement Disorders, Dublin, Ireland, 17–21 June 2012. Mov Disord 2012;27:S115, meeting abstract: 360.
Rick C, Clarke C, Sackley C, Walker M, Ives N, Patel S, et al. on behalf of the PD REHAB Collaborative Group. PD REHAB: randomised controlled trial to study the effectiveness and cost-effectiveness of physiotherapy and occupational therapy for people with PD. Mov Disord 2010;25:S717.
Dowling FP, Rick CE, Clarke CE, Walker M, Ives N, Patel S, et al. PD REHAB: randomised controlled trial to study the effectiveness and cost-effectiveness of physiotherapy and occupational therapy for people with PD. Parkinson’s UK conference, York, 2010.
