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Boonacker CWB, Rovers MM, Browning GG, et al. Adenoidectomy with or without grommets for children with otitis media: an individual patient data meta-analysis. Southampton (UK): NIHR Journals Library; 2014 Jan. (Health Technology Assessment, No. 18.5.)

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Adenoidectomy with or without grommets for children with otitis media: an individual patient data meta-analysis.

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Appendix 11Significant interaction effects for adenoidectomy with or without grommets compared with non-surgical treatment or grommets only

n (%)Adenoidectomy with or without unilateral or bilateral grommets (n = 767)Non-surgical treatment or unilateral or bilateral grommets only (n = 994)RD (95% CI)aNNTaRR or mean difference (95% CI)aAdjusted RR or mean difference (95% CI)ap-value for interactiona
Secondary outcome: presence of effusion for ≥ 50% of the time, n/N (%)
< 2 years291 (25.8)0/99 (0.0)0/192 (0.0)––––
≥ 2 years836 (74.2)153/376 (40.7)254/460 (55.2)−14.5% (−21.3% to −7.8%)70.74 (0.64 to 0.85)0.78 (0.68 to 0.89)0.07
Secondary outcome: surgery during the first 12 months of follow-up, n/N (%)
< 4 years1016 (57.8)31/441 (7.0)94/575 (16.3)−9.3% (−13.2% to −5.5%)110.43 (0.29 to 0.63)0.45 (0.31 to 0.66)
≥ 4 years742 (42.2)7/323 (2.2)78/419 (18.6)−16.4% (−20.5% to −12.4%)60.12 (0.05 to 0.25)0.13 (0.06 to 0.27)< 0.01
Secondary outcome: time with effusion during the first 12 months of follow-up (weeks), mean (SD)
Indication recurrent AOM303 (26.9)0.7 (2.7)1.0 (2.6)––−0.3 (−0.9 to 0.4)−0.2 (−0.8 to 0.4)
Indication persistent OME824 (73.1)20.8 (15.8)28.5 (18.0)––−7.7 (−10.0 to −5.4)−6.0 (−8.0 to −4.0)< 0.01
< 2 years291 (25.8)0.75 (2.8)1.1 (2.6)––−0.3 (−0.9 to 0.4)−0.2 (−0.9 to 0.4)
≥ 2 years836 (74.2)20.5 (15.8)28.2 (18.1)––−7.6 (−10.0 to −5.3)−5.9 (−7.9 to −3.8)< 0.01
< 4 years446 (39.6)5.3 (11.6)5.6 (13.0)––−0.2 (−2.6 to 2.1)−1.2 (−2.3 to −0.1)
≥ 4 years681 (60.4)23.2 (14.9)30.1 (17.0)––−7.0 (−9.4 to −4.5)−6.6 (−9.0 to −4.3)< 0.01
a

Bold text indicates values are statistically significant.

Copyright © Queen’s Printer and Controller of HMSO 2014. This work was produced by Boonacker et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

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Bookshelf ID: NBK261507
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