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Picot J, Cooper K, Bryant J, et al. The Clinical Effectiveness and Cost-Effectiveness of Bortezomib and Thalidomide in Combination Regimens with an Alkylating Agent and a Corticosteroid for the First-Line Treatment of Multiple Myeloma: A Systematic Review and Economic Evaluation. Southampton (UK): NIHR Journals Library; 2011 Dec. (Health Technology Assessment, No. 15.41.)
The Clinical Effectiveness and Cost-Effectiveness of Bortezomib and Thalidomide in Combination Regimens with an Alkylating Agent and a Corticosteroid for the First-Line Treatment of Multiple Myeloma: A Systematic Review and Economic Evaluation.
Show detailsThe quality of the cost-effectiveness studies was assessed using a critical appraisal checklist based on that by Drummond and Jefferson,118 Philips and colleagues,98 and the NICE reference case.
| Item | Celgene116 | Janssen–Cilag115 | |
|---|---|---|---|
| 1 | Is there a clear statement of the decision problem? | Y | Y |
| 2 | Is the comparator routinely used in UK NHS? | Y | Y |
| 3 | Is the patient group in the study similar to those of interest in UK NHS? | ? | Y |
| 4 | Is the health-care system or setting comparable to UK? | Y | Y |
| 5 | Is the perspective of the model clearly stated? | Y | Y |
| 6 | Is the study type and modelling methodology reasonable? | Y | Y |
| 7 | Is the model structure described and does it reflect the disease process? | ? | Y |
| 8 | Are assumptions about model structure listed and justified? | Y | Y |
| 9 | Are the data inputs for the model described and justified? | Y | Y |
| 10 | Is the effectiveness of the intervention established based on a systematic review? | Y | Y |
| 11 | Are health benefits measured in QALYs? | Y | Y |
| 12 | Are health benefits measured using a standardised and validated generic instrument? | Y | Y |
| 13 | Are the resource costs described and justified? | Y | Y |
| 14 | Have the costs and outcomes been discounted? | Y | Y |
| 15 | Has uncertainty been assessed? | Y | Y |
| 16 | Has the model been validated? | N | N |
Y, yes; N, no; ?, unclear/incomplete.
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