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Efficacy and Mechanism Evaluation (EME) publishes 'science driven' studies that are expected to provide substantial health gain with an ultimate view to improving health or patient care.
Contents
Volume 11 (2024)
- 11.17. Infliximab versus alpha interferon in the treatment of Behçet’s disease: the BIO BEHÇET’S RCTRobert J Moots, Farida Fortune, Richard Jackson, Tony Thornburn, Ann W Morgan, Dan Carr, Philip Ian Murray, Graham Robert Wallace, and Deva Situnayake.Southampton (UK): National Institute for Health and Care Research; October 2024.
- 11.16. Efficacy and safety of ketogenic diet in infants with epilepsy: KIWE RCTNatasha E Schoeler, Louise Marston, Laura Lyons, Sally Halsall, Ruchika Jain, Siobhan Titre-Johnson, Maryam Balogun, Simon J R Heales, Simon Eaton, Michael Orford, Elizabeth Neal, Christin Eltze, Elma Stephen, Andrew A Mallick, Finbar O’Callaghan, Shakti Agrawal, Alasdair Parker, Martin Kirkpatrick, Andreas Brunklaus, Ailsa McLellan, Helen McCullagh, Rajib Samanta, Rachel Kneen, Hui Jeen Tan, Anita Devlin, Manish Prasad, Rohini Rattihalli, Helen Basu, Archana Desurkar, Ruth Williams, Penny Fallon, Irwin Nazareth, Nicholas Freemantle, and J Helen Cross.Southampton (UK): National Institute for Health and Care Research; October 2024.
- 11.15. Development and evaluation of machine-learning methods in whole-body magnetic resonance imaging with diffusion weighted imaging for staging of patients with cancer: the MALIBO diagnostic test accuracy studyAndrea Rockall, Xingfeng Li, Nicholas Johnson, Ioannis Lavdas, Shalini Santhakumaran, A Toby Prevost, Dow-Mu Koh, Shonit Punwani, Vicky Goh, Nishat Bharwani, Amandeep Sandhu, Harbir Sidhu, Andrew Plumb, James Burn, Aisling Fagan, Alf Oliver, Georg J Wengert, Daniel Rueckert, Eric Aboagye, Stuart A Taylor, Ben Glocker; The MALIBO Investigators.Southampton (UK): National Institute for Health and Care Research; October 2024.
- 11.14. Determining the optimal route of faecal microbiota transplant in patients with ulcerative colitis: the STOP-Colitis pilot RCTMohammed N Quraishi, Catherine A Moakes, Mehmet Yalchin, Jonathan Segal, Natalie J Ives, Laura Magill, Susan E Manzoor, Konstantinos Gerasimidis, Shrushma Loi, Christel McMullan, Jonathan Mathers, Christopher Quince, Manjinder Kaur, Nicholas J Loman, Naveen Sharma, Peter Hawkey, Victoria McCune, Ben Nichols, Vaios Svolos, Caroline Kerbiriou, Claire McMurray, Andrew Beggs, Richard Hansen, Ailsa L Hart, Daniel R Gaya, and Tariq H Iqbal.Southampton (UK): National Institute for Health and Care Research; August 2024.
- 11.13. Bezafibrate as treatment in males for Barth syndrome: CARDIOMAN, a double-blind, placebo-controlled crossover RCTGuido Pieles, Colin Steward, Lucy Dabner, Laura Collet, Lucy Culliford, Karen Sheehan, Lucy Ellis, Michaela Damin, Eva Sammut, Nuno Duarte, Owen Burgess, Curtis Wadey, Craig Williams, John Crosby, Sarah Groves, Aidan Searle, Borko Amulic, Chris Rice, Chiara Bucciarelli-Ducci, Andrew Ness, Julian Hamilton-Shield, Chris A Rogers, and Barnaby C Reeves.Southampton (UK): National Institute for Health and Care Research; August 2024.
- 11.12. High-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent anthracycline cardiotoxicity: the Cardiac CARE RCTPeter Henriksen, Morag MacLean, Marek Atter, Steff Lewis, and Aryelly Rodriguez.Southampton (UK): National Institute for Health and Care Research; August 2024.
- 11.11. Efficacy and safety of eculizumab in children with Shiga-toxin-producing
Escherichia coli
haemolytic uraemic syndrome: the ECUSTEC RCTNatalie Ives, Rebecca Woolley, Moin A Saleem, Catherine A Moakes, Aoife Waters, Rodney D Gilbert, Hugh Jarrett, Elizabeth Brettell, Steve Nash, Louise K Farmer, Khadija Ourradi, and Sally A Johnson.Southampton (UK): National Institute for Health and Care Research; July 2024.
- 11.10. Prophylactic zoledronic acid therapy to prevent or modify Paget’s disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCTJonathan Phillips, Deepak Subedi, Steff C Lewis, Catriona Keerie, and Stuart H Ralston.Southampton (UK): National Institute for Health and Care Research; June 2024.
- 11.09. Gene therapy for choroideremia using an adeno-associated viral vector encoding Rab escort protein 1: the REGENERATE open-label trialJasmina Cehajic-Kapetanovic, Marco P Bellini, Laura J Taylor, Imran H Yusuf, Taha Soomro, Lyndon da Cruz, Robert E MacLaren; REGENERATE Study Group.Southampton (UK): National Institute for Health and Care Research; May 2024.
- 11.8. The effect of closed-loop glucose control on C-peptide secretion in youth with newly diagnosed type 1 diabetes: the CLOuD RCTCharlotte K Boughton, Janet M Allen, Julia Ware, Malgorzata E Wilinska, Sara Hartnell, Ajay Thankamony, Tabitha Randell, Atrayee Ghatak, Rachel EJ Besser, Daniela Elleri, Nicola Trevelyan, Fiona M Campbell, David Rankin, Barbara Kimbell, Julia Lawton, Judy Sibayan, Peter Calhoun, Ryan Bailey, Gareth Dunseath, and Roman Hovorka.Southampton (UK): National Institute for Health and Care Research; May 2024.
- 11.07. Automated closed-loop insulin delivery for the management of type 1 diabetes during pregnancy: the AiDAPT RCTTara TM Lee, Corinne Collett, Simon Bergford, Sara Hartnell, Eleanor M Scott, Robert S Lindsay, Katharine F Hunt, David R McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Rebecca M Reynolds, Emma Flanagan, Matthew Hammond, Lee Shepstone, Malgorzata E Wilinska, Judy Sibayan, Craig Kollman, Roy Beck, Roman Hovorka, and Helen R Murphy.Southampton (UK): National Institute for Health and Care Research; April 2024.
- 11.06. Intravenous immunoglobulin treatment for encephalitis in children aged 6 months to 16 years: the IgNiTE RCTMildred A Iro, Manish Sadarangani, Michael Absoud, Liberty Cantrell, Wui K Chong, Christopher Clark, Ava Easton, Victoria Gray, Matilda Hill, Rachel Kneen, Ming Lim, Xinxue Liu, Mike Pike, Tom Solomon, Angela Vincent, Louise Willis, Ly-Mee Yu, Andrew J Pollard; IgNiTE Study Team.Southampton (UK): National Institute for Health and Care Research; April 2024.
- 11.05. Withdrawal of renin-angiotensin system inhibitors’ effect on estimated glomerular filtration rate in adults with advanced kidney disease: the STOP-ACEi RCTSunil Bhandari, Samir Mehta, Arif Khwaja, John Cleland, Natalie Ives, Elizabeth Brettell, Marie Chadburn, Paul Cockwell; for the STOP-ACEi Trial Investigators.Southampton (UK): National Institute for Health and Care Research; March 2024.
- 11.04. Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCTToby M Maher, Veronica A Tudor, Peter Saunders, Fernando Zanghelini, Carlota Grossi Sampedro, Georgios Xydopoulos, Michael Gibbons, Sophie V Fletcher, Christopher P Denton, Maria Kokosi, Rachel K Hoyles, Helen Parfrey, Elisabetta A Renzoni, Athol U Wells, Deborah Ashby, Richard J Fordham, Matyas Szigeti, and Philip L Molyneaux.Southampton (UK): National Institute for Health and Care Research; February 2024.
- 11.03. Autologous stem cell transplantation with low-dose cyclophosphamide to improve mucosal healing in adults with refractory Crohn’s disease: the ASTIClite RCTJames O Lindsay, Daniel Hind, Lizzie Swaby, Hannah Berntsson, Mike Bradburn, Uday Bannur C, Jennifer Byrne, Christopher Clarke, Lauren Desoysa, Shahida Din, Richard Emsley, Gemma A Foulds, John Gribben, Christopher Hawkey, Peter M Irving, Peter Johnson, Majid Kazmi, Ellen Lee, Amanda Loban, Alan Lobo, Yashwant Mahida, Gordon Moran, Diana Papaioannou, Miles Parkes, Andrew Peniket, A Graham Pockley, Jack Satsangi, Sreedhar Subramanian, Simon Travis, Emily Turton, Ben Uttenthal, Sergio Rutella, and John A Snowden.Southampton (UK): National Institute for Health and Care Research; January 2024.
- 11.02. Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCTNicholas Crombie, Heidi A Doughty, Jonathan RB Bishop, Amisha Desai, Emily F Dixon, James M Hancox, Mike J Herbert, Caroline Leech, Simon J Lewis, Mark R Nash, David N Naumann, Karen Piper, Gemma Slinn, Hazel Smith, Iain M Smith, Rebekah K Wale, Alastair Wilson, Aisling Crombie, Mark Midwinter, Natalie Ives, and Gavin D Perkins.Southampton (UK): National Institute for Health and Care Research; January 2024.
- 11.01. Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCTHeather Lambert, Shaun Hiu, Malcolm Coulthard, John N S Matthews, Ruth Wood, Jean Crosier, Rachel Agbeko, Thomas Brick, Heather Duncan, David Grant, Quen Mok, Andrew Gustaf Nyman, John Pappachan, Paul Wellman, Chris Boucher, Joe Bulmer, Denise Chisholm, Kirsten Cromie, Victoria Emmet, Richard Feltbower, Michael Grayling, Rebecca Harrison, Eva-Maria Holstein, Ciara A Kennedy, Elaine McColl, Kevin Morris, Lee Norman, Julie Office, Roger Parslow, Christine Pattinson, Shriya Sharma, Jonathan Smith, Alison Steel, Rachel Steel, Jayne Straker, Lamprini Vrana, Jenn Walker, Mike Whitaker, Jim Wightman, Nina Wilson, and Lucy Wirz.Southampton (UK): National Institute for Health and Care Research; January 2024.
Volume 10 (2023)
- 10.09. Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trialDavid Gunn, Rabia Topan, Ron Fried, Ivana Holloway, Richard Brindle, Suzanne Hartley, Lorna Barnard, Maura Corsetti, S Mark Scott, Adam Farmer, Ayesha Akbar, Maria Eugenicos, Nigel Trudgill, Kapil Kapur, John McLaughlin, David S Sanders, Arvind Ramadas, Peter Whorwell, Lesley Houghton, Phil G Dinning, Qasim Aziz, Alexander C Ford, Amanda Farrin, and Robin Spiller.Southampton (UK): National Institute for Health and Care Research; October 2023.
- 10.08. Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding: the UCON randomised controlled trial and mechanism of action studyLucy HR Whitaker, Lee J Middleton, Lee Priest, Smita Odedra, Versha Cheed, Elaine P Nicholls, Alistair RW Williams, Neil Roberts, Clive E Stubbs, Konstantios Tryposkiadis, Hannah Bensoussane, Rohan Chodankar, Alison A Murray, Moira Nicol, Aleksandra O Tsolova, Kaiming Yin, Marcos Cruz, Hui Wei Leow, Lucy E Kershaw, Suzanne L McLenachan, Graham McKillop, Jane Walker, Scott I Semple, T Justin Clark, Mary Ann Lumsden, Dharani K Hapangama, Lucky Saraswat, Siladitya Bhattacharya, Paul Smith, Jane Daniels, and Hilary OD Critchley.Southampton (UK): National Institute for Health and Care Research; October 2023.
- 10.07. Bilateral versus single internal thoracic coronary artery bypass grafting: the ART RCTMarcus Flather, Arnaldo Dimagli, Umberto Benedetto, Belinda Lees, Alastair Gray, Stephen Gerry, Ajita Naik, Jo Cook, Mario Gaudino, Matthew Little, and David P Taggart.Southampton (UK): National Institute for Health and Care Research; October 2023.
- 10.06. Virtual reality supported therapy for the negative symptoms of schizophrenia: the V-NeST feasibility RCTMatteo Cella, Paul Tomlin, Daniel Robotham, Patrick Green, Helena Griffiths, Daniel Stahl, and Lucia Valmaggia.Southampton (UK): National Institute for Health and Care Research; September 2023.
- 10.05. Preventing kidney transplant failure by screening for antibodies against human leucocyte antigens followed by optimised immunosuppression: OuTSMART RCTDominic Stringer, Leanne Gardner, Olivia Shaw, Brendan Clarke, David Briggs, Judith Worthington, Matthew Buckland, Rachel Hilton, Michael Picton, Raj Thuraisingham, Richard Borrows, Richard Baker, Rose Tinch-Taylor, Robert Horne, Paul McCrone, Joanna Kelly, Caroline Murphy, Janet Peacock, and Anthony Dorling.Southampton (UK): National Institute for Health and Care Research; September 2023.
- 10.04. The impact of the Speech Systems Approach on intelligibility for children with cerebral palsy: a secondary analysisLindsay Pennington, Stuart Cunningham, Shaun Hiu, Ghada Khattab, and Vicky Ryan.Southampton (UK): National Institute for Health and Care Research; September 2023.
- 10.03. Subacromial spacers for adults with symptomatic, irreparable rotator cuff tears: the START:REACTS novel group sequential adaptive RCTAndrew Metcalfe, Susanne Arnold, Helen Parsons, Nicholas Parsons, Gev Bhabra, Jaclyn Brown, Howard Bush, Michael Diokno, Mark Elliott, Josephine Fox, Simon Gates, Elke Gemperlé Mannion, Aminul Haque, Charles Hutchinson, Rebecca Kearney, Iftekhar Khan, Tom Lawrence, James Mason, Usama Rahman, Nigel Stallard, Sumayyah Ul-Rahman, Aparna Viswanath, Sarah Wayte, Stephen Drew, and Martin Underwood.Southampton (UK): National Institute for Health and Care Research; August 2023.
- 10.02. Neuromuscular electrical stimulation as an adjunct to standard care in improving walking distances in intermittent claudication patients: the NESIC RCTLaura Burgess, Sasha Smith, Adarsh Babber, Joseph Shalhoub, Francesca Fiorentino, Consuelo Nohpal de la Rosa, Natalia Klimowska-Nassar, David M Epstein, Daniel Pérez Troncoso, Bruce Braithwaite, Ian Chetter, James Coulston, Manjit Gohel, Robert Hinchliffe, Gerard Stansby, and Alun H Davies.Southampton (UK): National Institute for Health and Care Research; July 2023.
- 10.01. Gefitinib and methotrexate to resolve tubal ectopic pregnancy: the GEM3 RCTCatherine A Moakes, Stephen Tong, Lee J Middleton, W Colin Duncan, Ben W Mol, Lucy H R Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Lauren C Sutherland, Ann M Doust, Jane P Daniels, and Andrew W Horne.Southampton (UK): National Institute for Health and Care Research; June 2023.
Volume 9 (2022)
- 9.9. Molecular selection of therapy in metastatic colorectal cancer: the FOCUS4 molecularly stratified RCTLouise C Brown, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Susan D Richman, Philip Quirke, Rachel Butler, Helen Roberts, Janet Graham, Richard H Wilson, and Timothy S Maughan.Southampton (UK): National Institute for Health and Care Research; December 2022.
- 9.8. Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia: the LACE factorial RCTMiles D Witham, Simon Adamson, Alison Avenell, Margaret M Band, Tufail Bashir, Peter T Donnan, Jacob George, Adrian Hapca, Cheryl Hume, Paul Kemp, Emma McKenzie, Kristina Pilvinyte, Christos Rossios, Karen Smith, Allan D Struthers, and Deepa Sumukadas.Southampton (UK): National Institute for Health and Care Research; August 2022.
- 9.7. Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA
RCTFrances Humby, Patrick Durez, Maya H Buch, Myles J Lewis, Michele Bombardieri, Christopher John, Hasan Rizvi, Louise Warren, Joanna Peel, Liliane Fossati-Jimack, Rebecca E Hands, Giovanni Giorli, Felice Rivellese, Juan D Cañete, Peter C Taylor, Peter Sasieni, João E Fonseca, Ernest Choy, and Costantino Pitzalis.Southampton (UK): National Institute for Health and Care Research; August 2022.
- 9.6. OROS-methylphenidate to reduce ADHD symptoms in male prisoners aged 16–25 years: a RCTPhilip Asherson, Lena Johansson, Rachel Holland, Megan Bedding, Andrew Forrester, Laura Giannulli, Ylva Ginsberg, Sheila Howitt, Imogen Kretzschmar, Stephen Lawrie, Craig Marsh, Caroline Kelly, Megan Mansfield, Clare McCafferty, Khuram Khan, Ulrich Müller-Sedgwick, John Strang, Grace Williamson, Lauren Wilson, Susan Young, Sabine Landau, and Lindsay Thomson.Southampton (UK): National Institute for Health and Care Research; June 2022.
- 9.5. Omalizumab for severe atopic dermatitis in 4- to 19-year-olds: the ADAPT RCTSusan MH Chan, Suzie Cro, Victoria Cornelius, Rahi Jahan, Suzana Radulovic, and Gideon Lack.Southampton (UK): National Institute for Health and Care Research; May 2022.
- 9.4. Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCTSteve Turner, Seonaidh Cotton, Jessica Wood, Victoria Bell, Edwin-Amalraj Raja, Neil W Scott, Heather Morgan, Louisa Lawrie, David Emele, Charlotte Kennedy, Graham Scotland, Shona Fielding, Graeme MacLennan, John Norrie, Mark Forrest, Erol Gaillard, Johan de Jongeste, Marielle Pijnenburg, Mike Thomas, and David Price.Southampton (UK): National Institute for Health and Care Research; May 2022.
- 9.3. An adapted social communication intervention at home and education to promote social communication change in children with severe autism: the PACT-G RCTJonathan Green, Kathy Leadbitter, Ceri Ellis, Lauren Taylor, Heather L Moore, Sophie Carruthers, Kirsty James, Carol Taylor, Matea Balabanovska, Sophie Langhorne, Catherine Aldred, Vicky Slonims, Victoria Grahame, Jeremy Parr, Neil Humphrey, Patricia Howlin, Helen McConachie, Ann Le Couteur, Tony Charman, Richard Emsley, and Andrew Pickles.Southampton (UK): National Institute for Health and Care Research; May 2022.
- 9.2. The interleukin 1 receptor antagonist anakinra to reduce disease severity of palmoplantar pustulosis in adults: APRICOT RCT and PLUM mechanistic studySuzie Cro, Victoria Cornelius, Francesca Capon, Jonathan Barker, David Burden, Christopher Griffiths, Helen Jane Lachmann, Helen McAteer, Prakash Patel, Andrew Pink, Nick Reynolds, Richard Warren, and Catherine Smith.Southampton (UK): NIHR Journals Library; March 2022.
- 9.1. Monoclonal antibody BTT1023 targeting vascular adhesion protein 1 for treating primary sclerosing cholangitis: BUTEO single-arm Phase II trialKatherine Arndtz, Yung-Yi Chen, Anna Rowe, Victoria Homer, Amanda Kirkham, Jessica Douglas-Pugh, Daniel Slade, Douglas Thorburn, Eleanor Barnes, Guruprasad Aithal, Philip Newsome, David Smith, David Adams, Christopher Weston, and Gideon Hirschfield.Southampton (UK): NIHR Journals Library; March 2022.
Volume 8 (2021)
- 8.20. A 10-year impact assessment of the Efficacy and Mechanism Evaluation (EME) programme: an independent mixed-method evaluation studyMaike C Rentel, Kelly Simpson, Anoushka Davé, Scott Carter, Margaret Blake, Jan Franke, Chris Hale, and Peter Varnai.Southampton (UK): NIHR Journals Library; November 2021.
- 8.19. Losartan to slow the progression of mild-to-moderate Alzheimer’s disease through angiotensin targeting: the RADAR RCTPatrick G Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyt, Shona L Clegg, Ian B Malone, Josephine Barnes, Casper Nielsen, Carole H Sudre, Aileen Wilson, N Jade Thai, Peter S Blair, Elizabeth J Coulthard, J Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David L Thomas, Nick C Fox, Ian Wilkinson, and Yoav Ben-Shlomo.Southampton (UK): NIHR Journals Library; November 2021.
- 8.18. Thoracoscopic surgical ablation versus catheter ablation as first-line treatment for long-standing persistent atrial fibrillation: the CASA-AF RCTShouvik Haldar, Habib R Khan, Vennela Boyalla, Ines Kralj-Hans, Simon Jones, Joanne Lord, Oluchukwu Onyimadu, Anitha Sathishkumar, Toufan Bahrami, Jonathan Clague, Anthony De Souza, Darrel Francis, Wajid Hussain, Julian Jarman, David G Jones, Zhong Chen, Neeraj Mediratta, Jonathan Hyde, Michael Lewis, Raad Mohiaddin, Tushar Salukhe, Caroline Murphy, Joanna Kelly, Rajdeep Khattar, William D Toff, Vias Markides, James McCready, Dhiraj Gupta, and Tom Wong.Southampton (UK): NIHR Journals Library; October 2021.
- 8.17. Variable short duration treatment versus standard treatment, with and without adjunctive ribavirin, for chronic hepatitis C: the STOP-HCV-1 non-inferiority, factorial RCTGraham S Cooke, Sarah Pett, Leanne McCabe, Christopher Jones, Richard Gilson, Sumita Verma, Stephen D Ryder, Jane D Collier, Stephen T Barclay, Aftab Ala, Sanjay Bhagani, Mark Nelson, Chin Lye Ch’Ng, Benjamin Stone, Martin Wiselka, Daniel Forton, Stuart McPherson, Rachel Halford, Dung Nguyen, David Smith, M Azim Ansari, Helen Ainscough, Emily Dennis, Fleur Hudson, Eleanor J Barnes, Ann Sarah Walker; the STOP-HCV trial team.Southampton (UK): NIHR Journals Library; October 2021.
- 8.16. Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of ‘closed-loop’ technologyKathryn Beardsall, Lynn Thomson, Catherine Guy, Simon Bond, Annabel Allison, Beatrice Pantaleo, Stavros Petrou, Sungwook Kim, David Dunger, and Roman Hovorka.Southampton (UK): NIHR Journals Library; October 2021.
- 8.15. Epithelium-off corneal cross-linking surgery compared with standard care in 10- to 16-year-olds with progressive keratoconus: the KERALINK RCTDaniel FP Larkin, Kashfia Chowdhury, Caroline J Doré, Catey Bunce, Jennifer M Burr, Emilia Caverly, Lisa French, Dimitra Kopsini, Anne Klepacz, Mathew Raynor, Matthew Edwards, and Stephen J Tuft.Southampton (UK): NIHR Journals Library; October 2021.
- 8.14. Lactoferrin impact on gut microbiota in preterm infants with late-onset sepsis or necrotising enterocolitis: the MAGPIE mechanisms of action studyNicholas Embleton, Janet Berrington, Stephen Cummings, Jon Dorling, Andrew Ewer, Alessandra Frau, Edmund Juszczak, John Kirby, Christopher Lamb, Clare Lanyon, Lauren Lett, William McGuire, Christopher Probert, Stephen Rushton, Mark Shirley, Christopher Stewart, and Gregory R Young.Southampton (UK): NIHR Journals Library; September 2021.
- 8.13. Paclitaxel-assisted balloon angioplasty of venous stenosis in haemodialysis access: PAVE RCTNarayan Karunanithy, Emily J Robinson, Francis Calder, Anthony Dorling, Janet L Peacock, Yanzhong Wang, Leanne M Gardner, and Michael G Robson.Southampton (UK): NIHR Journals Library; September 2021.
- 8.12. Planned delivery to improve postpartum cardiac function in women with preterm pre-eclampsia: the PHOEBE mechanisms of action study within the PHOENIX RCTFergus P McCarthy, Jamie O’Driscoll, Paul Seed, Anna Brockbank, Alice Cox, Carolyn Gill, Marcus Green, Mike Marber, Lucilla Poston, Anna Placzek, Andrew Shennan, Jenie Sparkes, Paul Leeson, Basky Thilaganathan, and Lucy C Chappell.Southampton (UK): NIHR Journals Library; September 2021.
- 8.11. Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCTPhilippa Garety, Thomas Ward, Richard Emsley, Kathryn Greenwood, Daniel Freeman, David Fowler, Elizabeth Kuipers, Paul Bebbington, Graham Dunn, and Amy Hardy.Southampton (UK): NIHR Journals Library; August 2021.
- 8.10. Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTsManu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane, and Daniel F McAuley.Southampton (UK): NIHR Journals Library; July 2021.
- 8.9. Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCTAndrew M Wilson, Allan B Clark, Anthony Cahn, Edwin R Chilvers, William Fraser, Matthew Hammond, David M Livermore, Toby M Maher, Helen Parfrey, Ann Marie Swart, Susan Stirling, David Thickett, and Moira Whyte.Southampton (UK): NIHR Journals Library; July 2021.
- 8.8. Emergent aneurysm treatment compared with treatment on neurological improvement in patients with ruptured poor-grade aneurysmal subarachnoid haemorrhage: the TOPSAT2 RCTPhilip White, Barbara Gregson, Elaine McColl, Paul Brennan, Alison Steel, Philippa Watts, Ruth Wood, Clare Bowes, Mohsen Javadpour, Amanda Weston, and Dipayan Mitra.Southampton (UK): NIHR Journals Library; July 2021.
- 8.7. Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCTChristopher C Butler, Eleri Owen-Jones, Mandy Lau, David Gillespie, Mark Lown, Philip C Calder, Helen Stanton, Mandy Wootton, Vivian Castro Herrera, Antony Bayer, Jane Davies, Alison Edwards, Mina Davoudianfar, Heather Rutter, Kerenza Hood, Michael Moore, Paul Little, Victoria Shepherd, Rachel Lowe, Elizabeth A Miles, Julia Townson, FD Richard Hobbs, and Nick A Francis.Southampton (UK): NIHR Journals Library; April 2021.
- 8.6. Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCTJennifer S Walsh, Richard Jacques, Lutz Schomburg, Tom Hill, John Mathers, Graham Williams, and Richard Eastell.Southampton (UK): NIHR Journals Library; April 2021.
- 8.5. New technologies for diagnosing active TB: the VANTDET diagnostic accuracy studyAlice Halliday, Pooja Jain, Long Hoang, Robert Parker, Mica Tolosa-Wright, Tereza Masonou, Nathan Green, Aime Boakye, Yemisi Takwoingi, Shea Hamilton, Vinay Mandagere, Anastasia Fries, Lachlan Coin, Jon Deeks, Peter J White, Michael Levin, Peter Beverley, Onn Min Kon, and Ajit Lalvani.Southampton (UK): NIHR Journals Library; April 2021.
- 8.4. Using cardiovascular magnetic resonance to define mechanisms of comorbidity and to measure the effect of biological therapy: the CADERA observational studySven Plein, Bara Erhayiem, Graham Fent, Jacqueline Andrews, John Greenwood, Paul Baxter, Elizabeth M Hensor, Sue Pavitt, and Maya H Buch.Southampton (UK): NIHR Journals Library; March 2021.
- 8.3. Long limb compared with standard limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCTAlexander Dimitri Miras, Anna Kamocka, Tricia Tan, Belén Pérez-Pevida, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Ameet Patel, Anne Margot Umpleby, Gary Frost, Stephen Robert Bloom, Ahmed Rashid Ahmed, and Francesco Rubino.Southampton (UK): NIHR Journals Library; February 2021.
- 8.2. Eplerenone versus placebo for chronic central serous chorioretinopathy: the VICI RCTAndrew Lotery, Sobha Sivaprasad, Abby O’Connell, Rosie A Harris, Lucy Culliford, Angela Cree, Savita Madhusudhan, Helen Griffiths, Lucy Ellis, Usha Chakravarthy, Tunde Peto, Chris A Rogers, and Barnaby C Reeves.Southampton (UK): NIHR Journals Library; January 2021.
- 8.1. Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy studyAshish Awasthi, Jamie Barbour, Andrew Beggs, Pradeep Bhandari, Daniel Blakeway, Matthew Brookes, James Brown, Matthew Brown, Germaine Caldwell, Samuel Clokie, Ben Colleypriest, Abby Conlin, Shanika de Silva, John de Caestecker, Jonathan Deeks, Anjan Dhar, Mark Dilworth, Edward Fogden, Stephen Foley, Deb Ghosh, Leonie Grellier, Ailsa Hart, Syed Samiul Hoque, Marietta Iacucci, Tariq Iqbal, Jonathan James, Mark Jarvis, Anthoor Jayaprakash, Satish Keshav, Laura Magill, Glenn Matthews, Joel Mawdsley, Simon McLaughlin, Samir Mehta, Kevin Monahan, Dion Morton, Senthil Murugesan, Miles Parkes, Valerie Pestinger, Chris Probert, Arvind Ramadas, Alessandro Rettino, Shaji Sebastian, Naveen Sharma, Michael Griffiths, Joanne Stockton, Venkat Subramanian, Nigel Suggett, Philippe Taniere, Julian Teare, Ajay M Verma, and Yvonne Wallis.Southampton (UK): NIHR Journals Library; January 2021.
Volume 7 (2020)
- 7.10. Stratifying risk of infection and response to therapy in patients with myeloma: a prognostic studyIlaria J Chicca, Jennifer LJ Heaney, Gulnaz Iqbal, Janet A Dunn, Stella Bowcock, Tim Planche, Guy Pratt, Kwee Yong, Eric Low, Jill Wood, Kerry Raynes, Helen Higgins, and Mark T Drayson.Southampton (UK): NIHR Journals Library; December 2020.
- 7.9. Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCTLucy C Chappell, Jennifer L Bell, Anne Smith, Catherine Rounding, Ursula Bowler, Louise Linsell, Edmund Juszczak, Sue Tohill, Amanda Redford, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, and Jim G Thornton.Southampton (UK): NIHR Journals Library; December 2020.
- 7.8. Mini-combined test compared with NICE guidelines for early risk-assessment for pre-eclampsia: the SPREE diagnostic accuracy studyLiona C Poon, David Wright, Steve Thornton, Ranjit Akolekar, Peter Brocklehurst, and Kypros H Nicolaides.Southampton (UK): NIHR Journals Library; November 2020.
- 7.7. Gabapentin to reduce pain in women aged between 18 and 50 years with chronic pelvic pain: the GaPP2 RCTCatherine A Hewitt, Katy Vincent, Lee J Middleton, Liana Romaniuk, Magda Koscielniak, Ann M Doust, Judy Birch, Heather Whalley, Jane P Daniels, and Andrew W Horne.Southampton (UK): NIHR Journals Library; November 2020.
- 7.6. A duodenal sleeve bypass device added to intensive medical therapy for obesity with type 2 diabetes: a RCTAruchuna Ruban, Michael A Glaysher, Alexander D Miras, Anthony P Goldstone, Christina G Prechtl, Nicholas Johnson, Jia Li, Madhawi Aldhwayan, Ghadah Aldubaikhi, Ben Glover, Joanne Lord, Olu Onyimadu, Emmanuela Falaschetti, Natalia Klimowska-Nassar, Hutan Ashrafian, James Byrne, and Julian P Teare.Southampton (UK): NIHR Journals Library; November 2020.
- 7.5. Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCTPeter J McCartney, Hany Eteiba, Annette M Maznyczka, Margaret McEntegart, John P Greenwood, Douglas F Muir, Saqib Chowdhary, Anthony H Gershlick, Clare Appleby, James M Cotton, Andrew Wragg, Nick Curzen, Keith G Oldroyd, Mitchell Lindsay, J Paul Rocchiccioli, Aadil Shaukat, Richard Good, Stuart Watkins, Keith Robertson, Christopher Malkin, Lynn Martin, Lynsey Gillespie, Thomas J Ford, Mark C Petrie, Peter W Macfarlane, R Campbell Tait, Paul Welsh, Naveed Sattar, Robin A Weir, Keith A Fox, Ian Ford, Alex McConnachie, and Colin Berry.Southampton (UK): NIHR Journals Library; November 2020.
- 7.4. Spironolactone to improve exercise tolerance in people with permanent atrial fibrillation and preserved ejection fraction: the IMPRESS-AF RCTEduard Shantsila, Farhan Shahid, Yongzhong Sun, Jonathan J Deeks, Ronnie Haynes, Melanie Calvert, James P Fisher, Paulus Kirchhof, Paramjit S Gill, and Gregory YH Lip.Southampton (UK): NIHR Journals Library; July 2020.
- 7.3. Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCTFloriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados, Ian Marshall, Bhavana Solanky, Rebecca S Samson, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Sharmilee Gnanapavan, Gavin Giovannoni, Claudia AM Gandini Wheeler-Kingshott, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J Weir, Nigel Stallard, Siddharthan Chandran, and Jeremy Chataway.Southampton (UK): NIHR Journals Library; May 2020.
- 7.2. Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer’s disease: the MADE Phase II, three-arm RCTRobert Howard, Olga Zubko, Richard Gray, Rosie Bradley, Emma Harper, Linda Kelly, Lynn Pank, John O’Brien, Chris Fox, Naji Tabet, Gill Livingston, Peter Bentham, Rupert McShane, Alistair Burns, Craig Ritchie, Suzanne Reeves, Simon Lovestone, Clive Ballard, Wendy Noble, Gordon Wilcock, and Ramin Nilforooshan.Southampton (UK): NIHR Journals Library; April 2020.
- 7.1. Positron emission tomography to image cerebral neuroinflammation in ischaemic stroke: a pilot studyEszter Visi, Rainer Hinz, Martin Punter, Arshad Majid, Alexander Gerhard, and Karl Herholz.Southampton (UK): NIHR Journals Library; February 2020.
Volume 6 (2019)
- 6.13. Identifying and treating high blood pressure in men under 55 years with grade 1 hypertension: the TREAT CASP study and RCTBryan Williams, Ewan McFarlane, Dawid Jedrzejewski, and Peter S Lacy.Southampton (UK): NIHR Journals Library; December 2019.
- 6.12. Platelet-rich plasma injection for adults with acute Achilles tendon rupture: the PATH-2 RCTJoseph Alsousou, David J Keene, Paul Harrison, Philippa Hulley, Susan Wagland, Jacqueline Y Thompson, Scott R Parsons, Christopher Byrne, Michael M Schlüssel, Heather M O’Connor, Susan J Dutton, Sarah E Lamb, and Keith Willett.Southampton (UK): NIHR Journals Library; November 2019.
- 6.11. Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCTRima K Dhillon-Smith, Lee J Middleton, Kirandeep K Sunner, Versha Cheed, Krys Baker, Samantha Farrell-Carver, Ruth Bender-Atik, Rina Agrawal, Kalsang Bhatia, Edmond Edi-Osagie, Tarek Ghobara, Pratima Gupta, Davor Jurkovic, Yacoub Khalaf, Marjory MacLean, Chris McCabe, Khashia Mulbagal, Natalie Nunes, Caroline Overton, Siobhan Quenby, Rajendra Rai, Nick Raine-Fenning, Lynne Robinson, Jackie Ross, Andrew Sizer, Rachel Small, Alex Tan, Martyn Underwood, Mark D Kilby, Kristien Boelaert, Jane Daniels, Shakila Thangaratinam, Shiao-Yng Chan, and Arri Coomarasamy.Southampton (UK): NIHR Journals Library; October 2019.
- 6.10. Robotic-assisted surgery compared with laparoscopic resection surgery for rectal cancer: the ROLARR RCTDavid Jayne, Alessio Pigazzi, Helen Marshall, Julie Croft, Neil Corrigan, Joanne Copeland, Philip Quirke, Nicholas West, Richard Edlin, Claire Hulme, and Julia Brown.Southampton (UK): NIHR Journals Library; September 2019.
- 6.9. Oral morphine analgesia for preventing pain during invasive procedures in non-ventilated premature infants in hospital: the Poppi RCTVaneesha Monk, Fiona Moultrie, Caroline Hartley, Amy Hoskin, Gabrielle Green, Jennifer L Bell, Caz Stokes, Ed Juszczak, Jane Norman, Richard Rogers, Chetan Patel, Eleri Adams, and Rebeccah Slater.Southampton (UK): NIHR Journals Library; August 2019.
- 6.8. Very low-dose dexamethasone to facilitate extubation of preterm babies at risk of bronchopulmonary dysplasia: the MINIDEX feasibility RCTHelen Yates, Virginia Chiocchia, Louise Linsell, Nicolas Orsi, Edmund Juszczak, Kathryn Johnson, Philip Chetcuti, Claire Illingworth, Pollyanna Hardy, Vaneesha Monk, Simon Newell, and Mark Turner.Southampton (UK): NIHR Journals Library; August 2019.
- 6.7. Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCTBill Deakin, John Suckling, Paola Dazzan, Eileen Joyce, Stephen M Lawrie, Rachel Upthegrove, Nusrat Husain, Imran B Chaudhry, Graham Dunn, Peter B Jones, Danuta Lisiecka-Ford, Shôn Lewis, Thomas RE Barnes, Steven CR Williams, Carmine M Pariante, Emma Knox, Richard J Drake, Richard Smallman, and Nicholas M Barnes.Southampton (UK): NIHR Journals Library; August 2019.
- 6.6. Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCTSudeep Pushpakom, Ruwanthi Kolamunnage-Dona, Claire Taylor, Terry Foster, Catherine Spowart, Marta Garcia-Finana, Graham J Kemp, Thomas Jaki, Saye Khoo, Paula Williamson, and Munir Pirmohamed.Southampton (UK): NIHR Journals Library; July 2019.
- 6.5. Dopamine Augmented Rehabilitation in Stroke (DARS): a multicentre double-blind, randomised controlled trial of co-careldopa compared with placebo, in addition to routine NHS occupational and physical therapy, delivered early after stroke on functional recoveryGary A Ford, Bipin B Bhakta, Alastair Cozens, Bonnie Cundill, Suzanne Hartley, Ivana Holloway, David Meads, John Pearn, Sharon Ruddock, Catherine M Sackley, Eirini-Christina Saloniki, Gillian Santorelli, Marion F Walker, and Amanda J Farrin.Southampton (UK): NIHR Journals Library; July 2019.
- 6.4. Eicosapentaenoic acid and/or aspirin for preventing colorectal adenomas during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: the seAFOod RCTMark A Hull, Kirsty Sprange, Trish Hepburn, Wei Tan, Aisha Shafayat, Colin J Rees, Gayle Clifford, Richard F Logan, Paul M Loadman, Elizabeth A Williams, Diane Whitham, and Alan A Montgomery.Southampton (UK): NIHR Journals Library; June 2019.
- 6.3. Developing and applying a framework to understand mechanisms of action in group-based, behaviour change interventions: the MAGI mixed-methods studyAleksandra J Borek, Jane R Smith, Colin J Greaves, Fiona Gillison, Mark Tarrant, Sarah Morgan-Trimmer, Rose McCabe, and Charles Abraham.Southampton (UK): NIHR Journals Library; June 2019.
- 6.2. Lightmasks that prevent dark adaptation for non-central diabetic macular oedema: the CLEOPATRA RCTSobha Sivaprasad, Joana Vasconcelos, Helen Holmes, Caroline Murphy, Joanna Kelly, Philip Hykin, and Andrew Toby Prevost.Southampton (UK): NIHR Journals Library; February 2019.
- 6.1. Sperm selection for assisted reproduction by prior hyaluronan binding: the HABSelect RCTJackson Kirkman-Brown, Sue Pavitt, Yacoub Khalaf, Sheena Lewis, Richard Hooper, Siladitya Bhattacharya, Arri Coomarasamy, Vinay Sharma, Daniel Brison, Gordon Forbes, Robert West, Allan Pacey, Kate Brian, Rachel Cutting, Virginia Bolton, and David Miller.Southampton (UK): NIHR Journals Library; February 2019.
Volume 5 (2018)
- 5.7. Radically open dialectical behaviour therapy for refractory depression: the RefraMED RCTThomas R Lynch, Roelie J Hempel, Ben Whalley, Sarah Byford, Rampaul Chamba, Paul Clarke, Susan Clarke, David Kingdon, Heather O’Mahen, Bob Remington, Sophie C Rushbrook, James Shearer, Maggie Stanton, Michaela Swales, Alan Watkins, and Ian T Russell.Southampton (UK): NIHR Journals Library; December 2018.
- 5.6. Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCTAnthony C Gordon, Shalini Santhakumaran, Farah Al-Beidh, Robert ML Orme, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Josie K Ward, Kieran P O’Dea, Timothy Felton, Mary Cross, Janis Best-Lane, Jonas Lexow, Ashley Campbell, and Deborah Ashby.Southampton (UK): NIHR Journals Library; November 2018.
- 5.5. Intravitreal aflibercept compared with panretinal photocoagulation for proliferative diabetic retinopathy: the CLARITY non-inferiority RCTSobha Sivaprasad, Philip Hykin, A Toby Prevost, Joana Vasconcelos, Amy Riddell, Jayashree Ramu, Caroline Murphy, Joanna Kelly, Rhiannon Tudor Edwards, Seow Tien Yeo, James Bainbridge, David Hopkins, and Beverley White-Alao.Southampton (UK): NIHR Journals Library; October 2018.
- 5.4. Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide for abdominal aortic aneurysm: a risk prediction studyRachael Forsythe, Olivia McBride, Jennifer Robson, Catriona Graham, Noel Conlisk, Peter Hoskins, Fiona Wee, and David Newby.Southampton (UK): NIHR Journals Library; September 2018.
- 5.3. Functional strength training versus movement performance therapy for upper limb motor recovery early after stroke: a RCTValerie M Pomeroy, Susan M Hunter, Heidi Johansen-Berg, Nick S Ward, Niamh Kennedy, Elizabeth Chandler, Christopher J Weir, John Rothwell, Alan Wing, Michael Grey, Garry Barton, and Nick Leavey.Southampton (UK): NIHR Journals Library; June 2018.
- 5.2. Rituximab for the treatment of fatigue in primary biliary cholangitis (formerly primary biliary cirrhosis): a randomised controlled trialAmardeep Khanna, Laura Jopson, Denise Howel, Andrew Bryant, Andrew Blamire, Julia L Newton, Jennifer Wilkinson, Alison J Steel, Jennifer Bainbridge, Renae Stefanetti, Sophie Cassidy, David Houghton, and David E Jones.Southampton (UK): NIHR Journals Library; April 2018.
- 5.1. Simvastatin to reduce pulmonary dysfunction in patients with acute respiratory distress syndrome: the HARP-2 RCTDaniel F McAuley, John G Laffey, Cecilia M O’Kane, Gavin D Perkins, Brian Mullan, Thomas J Trinder, Paul Johnston, Phillip A Hopkins, Andrew J Johnston, Lynn Murphy, Christine McNally, Ashley M Agus, Clíona McDowell, and Colette Jackson.Southampton (UK): NIHR Journals Library; January 2018.
Volume 4 (2017)
- 4.5. A randomised placebo-controlled Phase III multicentre trial: low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome (LIPS trial)Andreas Goebel, Jatinder Bisla, Roy Carganillo, Claire Cole, Bernhard Frank, Rima Gupta, Mairi James, Joanna Kelly, Candy McCabe, Holly Milligan, Caroline Murphy, Nick Padfield, Ceri Phillips, Helen Poole, Mark Saunders, Mick Serpell, Nick Shenker, Karim Shoukrey, Lynne Wyatt, and Gareth Ambler.Southampton (UK): NIHR Journals Library; November 2017.
- 4.4. A randomised, double-blind, parallel-group trial to assess mercaptopurine versus placebo to prevent or delay recurrence of Crohn’s disease following surgical resection (TOPPIC)Jack Satsangi, Nicholas A Kennedy, Craig Mowat, Ian Arnott, Catriona Keerie, Steff Lewis, and Holly Ennis.Southampton (UK): NIHR Journals Library; September 2017.
- 4.3. The REFER (REFer for EchocaRdiogram) study: a prospective validation and health economic analysis of a clinical decision rule, NT-proBNP or their combination in the diagnosis of heart failure in primary careClare J Taylor, Mark Monahan, Andrea K Roalfe, Pelham Barton, Rachel Iles, and FD Richard Hobbs.Southampton (UK): NIHR Journals Library; April 2017.
- 4.2. Randomised controlled trial of ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT study)Ian M Anderson, Andrew Blamire, Tim Branton, Sabrina Brigadoi, Ross Clark, Darragh Downey, Graham Dunn, Andrew Easton, Rebecca Elliott, Clare Elwell, Katherine Hayden, Fiona Holland, Salman Karim, Jo Lowe, Colleen Loo, Rajesh Nair, Timothy Oakley, Antony Prakash, Parveen K Sharma, Stephen R Williams, and R Hamish McAllister-Williams.Southampton (UK): NIHR Journals Library; March 2017.
- 4.1. Evaluation of Array Comparative genomic Hybridisation in prenatal diagnosis of fetal anomalies: a multicentre cohort study with cost analysis and assessment of patient, health professional and commissioner preferences for array comparative genomic hybridisationStephen C Robson, Lyn S Chitty, Stephen Morris, Talitha Verhoef, Gareth Ambler, Diana G Wellesley, Ruth Graham, Claire Leader, Jane Fisher, and John A Crolla.Southampton (UK): NIHR Journals Library; February 2017.
Volume 3 (2016)
- 3.10. A randomised placebo-controlled trial investigating efficacy and mechanisms of low-dose intradermal allergen immunotherapy in treatment of seasonal allergic rhinitisAnna Slovick, Abdel Douiri, Rachel Muir, Andrea Guerra, Konstantinos Tsioulos, Evie Haye, Emily PS Lam, Joanna Kelly, Janet L Peacock, Sun Ying, Mohamed H Shamji, David J Cousins, Stephen R Durham, and Stephen J Till.Southampton (UK): NIHR Journals Library; December 2016.
- 3.9. The REFLO-STEMI (REperfusion Facilitated by LOcal adjunctive therapy in ST-Elevation Myocardial Infarction) trial: a randomised controlled trial comparing intracoronary administration of adenosine or sodium nitroprusside with control for attenuation of microvascular obstruction during primary percutaneous coronary interventionSheraz A Nazir, Jamal N Khan, Islam Z Mahmoud, John P Greenwood, Daniel J Blackman, Vijay Kunadian, Martin Been, Keith R Abrams, Robert Wilcox, AA Jennifer Adgey, Gerry P McCann, and Anthony H Gershlick.Southampton (UK): NIHR Journals Library; December 2016.
- 3.8. A randomised, double-blind, placebo-controlled study to evaluate the efficacy of oral azithromycin as a supplement to standard care for adult patients with acute exacerbations of asthma (the AZALEA trial)Sebastian L Johnston, Matyas Szigeti, Mary Cross, Christopher Brightling, Rekha Chaudhuri, Timothy Harrison, Adel Mansur, Laura Robison, Zahid Sattar, David Jackson, Patrick Mallia, Ernie Wong, Christopher Corrigan, Bernard Higgins, Philip Ind, Dave Singh, Neil Thomson, Deborah Ashby, and Anoop Chauhan.Southampton (UK): NIHR Journals Library; October 2016.
- 3.7. Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complicationsCarolyn A Chiswick, Rebecca M Reynolds, Fiona C Denison, Amanda J Drake, Shareen Forbes, David E Newby, Brian R Walker, Siobhan Quenby, Susan Wray, Andrew Weeks, Hany Lashen, Aryelly Rodriguez, Gordon D Murray, Sonia Whyte, Ruth Andrew, Natalie Homer, Scott Semple, Calum Gray, Marian C Aldhous, Karen Noble, Sarah Cunningham-Burley, Alice Keely, and Jane E Norman.Southampton (UK): NIHR Journals Library; August 2016.
- 3.6. Next Generation intraoperative Lymph node staging for Stratified colon cancer surgery (GLiSten): a multicentre, multinational feasibility study of fluorescence in predicting lymph node-positive diseaseHelen Andrew, Gemma Gossedge, Julie Croft, Neil Corrigan, Julia M Brown, Nicholas West, Philip Quirke, Damian Tolan, Ronan Cahill, and David G Jayne.Southampton (UK): NIHR Journals Library; August 2016.
- 3.5. A randomised, double-blind, placebo-controlled trial of repeated
nebulisation of non-viral cystic fibrosis transmembrane conductance regulator
(CFTR) gene therapy in patients with cystic
fibrosisEric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg; on behalf of the UK Cystic Fibrosis Gene Therapy Consortium.Southampton (UK): NIHR Journals Library; July 2016.
- 3.4. Effect of Remote Ischaemic preconditioning on Clinical outcomes in patients undergoing Coronary Artery bypass graft surgery (ERICCA study): a multicentre double-blind randomised controlled clinical trialDerek J Hausenloy, Luciano Candilio, Richard Evans, Cono Ariti, David P Jenkins, Shyamsunder Kolvekar, Rosemary Knight, Gudrun Kunst, Christopher Laing, Jennifer M Nicholas, John Pepper, Steven Robertson, Maria Xenou, Timothy Clayton, and Derek M Yellon.Southampton (UK): NIHR Journals Library; June 2016.
- 3.3. Wilms’ tumour antigen 1 Immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation: a Phase II non-randomised clinical trial (WIN)Christian Ottensmeier, Megan Bowers, Debbie Hamid, Tom Maishman, Scott Regan, Wendy Wood, Angelica Cazaly, and Louise Stanton.Southampton (UK): NIHR Journals Library; April 2016.
- 3.2. Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trialSabita Uthaya, Xinxue Liu, Daphne Babalis, Caroline Dore, Jane Warwick, Jimmy Bell, Louise Thomas, Deborah Ashby, Giuliana Durighel, Ash Ederies, Monica Yanez-Lopez, and Neena Modi.Southampton (UK): NIHR Journals Library; March 2016.
- 3.1. The randomised Complete versus Lesion-only PRimary percutaneous coronary Intervention Trial: Cardiovascular Magnetic Resonance imaging substudy (CvLPRIT-CMR)Gerry P McCann, Jamal N Khan, John P Greenwood, Sheraz A Nazir, Miles Dalby, Nick Curzen, Simon Hetherington, Damian J Kelly, Daniel J Blackman, Arne Ring, Charles Peebles, Joyce Wong, Thiagarajah Sasikaran, Marcus Flather, Howard Swanton, and Anthony H Gershlick.Southampton (UK): NIHR Journals Library; January 2016.
Volume 2 (2015)
- 2.6. Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate 5-lipoxygenase (ALOX5) promoter genotype: a multicentre, randomised, placebo-controlled trialChinedu Nwokoro, Hitesh Pandya, Stephen Turner, Sandra Eldridge, Christopher J Griffiths, Tom Vulliamy, David Price, Marek Sanak, John W Holloway, Rossa Brugha, Lee Koh, Iain Dickson, Clare Rutterford, and Jonathan Grigg.Southampton (UK): NIHR Journals Library; November 2015.
- 2.5. A randomised controlled study of Bronchoscopic Lung Volume Reduction with endobronchial valves for patients with Heterogeneous emphysema and Intact interlobar Fissures: the BeLieVeR-HIFi studyZaid Zoumot, Claire Davey, Simon Jordan, William H McNulty, Denis H Carr, Matthew D Hind, David M Hansell, Michael B Rubens, Winston Banya, Michael I Polkey, Pallav L Shah, and Nicholas S Hopkinson.Southampton (UK): NIHR Journals Library; September 2015.
- 2.4. Randomised controlled trial of Antiglucocorticoid augmentation (metyrapone) of antiDepressants in Depression (ADD Study)I Nicol Ferrier, Ian M Anderson, Jane Barnes, Peter Gallagher, Heinz CR Grunze, Peter M Haddad, Allan O House, Tom Hughes, Adrian J Lloyd, Chrysovalanto Mamasoula, Elaine McColl, Simon Pearce, Najma Siddiqi, Baxi Sinha, Chris Speed, Nick Steen, June Wainwright, Stuart Watson, Fiona H Winter, R Hamish McAllister-Williams; the ADD Study Team.Southampton (UK): NIHR Journals Library; June 2015.
- 2.3. REmote preconditioning for Protection Against Ischaemia–Reperfusion in renal transplantation (REPAIR): a multicentre, multinational, double-blind, factorial designed randomised controlled trialRaymond MacAllister, Tim Clayton, Rosemary Knight, Steven Robertson, Jennifer Nicholas, Madhur Motwani, and Kristin Veighey.Southampton (UK): NIHR Journals Library; May 2015.
- 2.2. Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trialChing Lam, Wei Tan, Matthew Leighton, Margaret Hastings, Melanie Lingaya, Yirga Falcone, Xiaoying Zhou, Luting Xu, Peter Whorwell, Andrew F Walls, Abed Zaitoun, Alan Montgomery, and Robin C Spiller.Southampton (UK): NIHR Journals Library; March 2015.
- 2.1. An explanatory randomised controlled trial testing the effects of targeting worry in patients with persistent persecutory delusions: the Worry Intervention Trial (WIT)Daniel Freeman, Graham Dunn, Helen Startup, and David Kingdon.Southampton (UK): NIHR Journals Library; March 2015.
Volume 1 (2014)
- 1.4. Study of induction of Tolerance to Oral Peanut: a randomised controlled trial of desensitisation using peanut oral immunotherapy in children (STOP II)Katherine Anagnostou, Sabita Islam, Yvonne King, Loraine Foley, Laura Pasea, Chris Palmer, Simon Bond, Pamela Ewan, and Andrew Clark.Southampton (UK): NIHR Journals Library; December 2014.
- 1.3. A multicentre observational study evaluating image-guided radiotherapy for more accurate partial-breast intensity-modulated radiotherapy: comparison with standard imaging techniqueEmma J Harris, Mukesh Mukesh, Rajesh Jena, Angela Baker, Harry Bartelink, Corrinne Brooks, June Dean, Ellen M Donovan, Sandra Collette, Sally Eagle, John D Fenwick, Peter H Graham, Jo S Haviland, Anna M Kirby, Helen Mayles, Robert A Mitchell, Rosalind Perry, Philip Poortmans, Andrew Poynter, Glyn Shentall, Jenny Titley, Alistair Thompson, John R Yarnold, Charlotte E Coles, Philip M Evans; on behalf of the IMPORT Trials Management Group.Southampton (UK): NIHR Journals Library; November 2014.
- 1.2. Alexander technique and Supervised Physiotherapy Exercises in back paiN (ASPEN): a four-group randomised feasibility trialPaul Little, Beth Stuart, Maria Stokes, Carolyn Nicholls, Lisa Roberts, Stephen Preece, Tim Cacciatore, Simon Brown, George Lewith, Adam Geraghty, Lucy Yardley, Gilly O’Reilly, Caroline Chalk, Debbie Sharp, and Peter Smith.Southampton (UK): NIHR Journals Library; October 2014.
- 1.1. Imaging perfusion deficits, arterial patency and thrombolysis safety and efficacy in acute ischaemic stroke. An observational study of the effect of advanced imaging methods in The Third International Stroke Trial (IST-3), a randomised controlled trialJoanna M Wardlaw, Trevor Carpenter, Eleni Sakka, Grant Mair, Geoff Cohen, Kirsten Shuler, Jeb M Palmer, Karen Innes, and Peter A Sandercock.Southampton (UK): NIHR Journals Library; July 2014.
- NLM CatalogRelated NLM Catalog Entries
- Efficacy and Mechanism EvaluationEfficacy and Mechanism Evaluation
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform 1 [Homo sap...NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform 1 [Homo sapiens]gi|7657369|ref|NP_055037.1|Protein
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