List of abbreviations

Robert Howard; Olga Zubko; Richard Gray; Rosie Bradley; Emma Harper; Linda Kelly; Lynn Pank; John O’Brien; Chris Fox; Naji Tabet; Gill Livingston; Peter Bentham; Rupert McShane; Alistair Burns; Craig Ritchie; Suzanne Reeves; Simon Lovestone; Clive Ballard; Wendy Noble; Gordon Wilcock; Ramin Nilforooshan

List of abbreviations

Aβ: β-amyloid
AD: Alzheimer's disease
ALS: amyotrophic lateral sclerosis
BADLS: Bristol Activities of Daily Living Scale
DeNDRoN: Dementias and Neurodegenerative Diseases Research Network
GP: general practitioner
IMP: investigational medicinal product
MADE: Minocycline in Alzheimer's Disease Efficacy
MMSE: Mini Mental State Examination
MR: modified release
NDPH: Nuffield Department of Population Health
NIA–AA: National Institute on Aging–Alzheimer’s Association
NIHR: National Institute for Health Research
NRES: National Research Ethics Service
NSAID: non-steroidal anti-inflammatory drug
PI: principal investigator
QP: qualified person
REC: Research Ethics Committee
SAE: serious adverse event
SD: standard deviation
SLE: systemic lupus erythematosus
sMMSE: standardised Mini Mental State Examination
TSC: Trial Steering Committee

Publication Details

Copyright

Copyright © Queen’s Printer and Controller of HMSO 2020. This work was produced by Howard et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Publisher

NIHR Journals Library, Southampton (UK)

NLM Citation

Howard R, Zubko O, Gray R, et al. Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer’s disease: the MADE Phase II, three-arm RCT. Southampton (UK): NIHR Journals Library; 2020 Apr. (Efficacy and Mechanism Evaluation, No. 7.2.) List of abbreviations.