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Helfand M, Peterson K. Drug Class Review: Triptans: Final Report Update 4 [Internet]. Portland (OR): Oregon Health & Science University; 2009 Jun.
This publication is provided for historical reference only and the information may be out of date.
| Triptan dose | Triptan n/N (%) | Placebo n/N (%) | Relative risk (95% CI) NNT | Cochrane Q (degrees of freedom), P value |
|---|---|---|---|---|
| 2-hour pain-free | ||||
| Frovatriptan 2.5 mg | 67/241 (28%) | 48/241 (20%) | 1.40 (1.11, 1.76) NNT=12 | N/A |
| Almotriptan 12.5 mg | 110/265 (41%) | 64/262 (24%) | 1.71 (1.32, 2.21) NNT=6 | 0.67 (df=1) P=0.41 |
| Rizatriptan 10 mg | 395/682 (60%) | 107/334 (31%) | 1.86 (1.57, 2.21) NNT=3 | 0.03 (df=1) P=0.86 |
| Zolmitriptan 5 mg | 58/136 (43%) | 25/141 (18%) | 2.41 (1.81, 3.20) NNT=4 | N/A |
| Eletriptan 40 mg | 37/55 (68%) | 14/57 (25%) | 2.72 (1.92, 3.84) NNT=2 | N/A |
| Treximet 85 mg/500 mg | 400/826 (48%) | 131/820 (16%) | 3.12 (2.64, 3.69) NNT=3 | 1.12 (df=3) P=0.77 |
| S-RT 100 mg | 94/142 (66%) | 30/153 (20%) | 3.38 (2.65, 4.30) NNT=2 | N/A |
| 24-hour sustained pain-free | ||||
| Almotriptan 12.5 mg | 87/265 (33%) | 42/262 (16%) | 2.08 (1.12, 3.86) NNT=6 | 3.49 (df=1) P=0.06 |
| Treximet 85 mg/500 mg | 313/826 (38%) | 92/820 (11%) | 3.21 (2.63, 3.91) NNT=4 | 1.18 (df=3) P=0.76 |
| Eletriptan 40 mg | 34/55 (56%) | 10/57 (18%) | 3.21 (2.09, 4.94) NNT=3 | N/A |
| Rizatriptan 10 mg | 310/682 (45%) | 83/344 (24%) | 3.52 (1.67, 7.42) NNT=5 | 7.39 (df=1) P=0.01 |
| S-RT 100 mg | 57/142 (40%) | 15/153 (10%) | 4.09 (2.83, 5.92) NNT=3 | N/A |
- Appendix E. Pooled relative risks (95% confidence interval) for pain-free outcom...Appendix E. Pooled relative risks (95% confidence interval) for pain-free outcomes in placebo-controlled trials of early treatment with triptans - Drug Class Review: Triptans
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