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Tran K, Coyle K, Jabr MF, et al. Drugs for Pulmonary Arterial Hypertension: Comparative Efficacy, Safety, and Cost-Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Mar.
See Section 5.1 Literature Search Strategy for more details on literature search methods.
| OVERVIEW | |
|---|---|
| Interface: | Ovid |
| Databases: | Embase 1974 to present MEDLINE Daily and MEDLINE 1946 to present MEDLINE In-Process & Other Non-Indexed Citations Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid. |
| Date of Search: | September 12, 2013 |
| Alerts: | Weekly search updates until finalization of project |
| Study Types: | HTA/SR/MA, all clinical trials, observational studies |
| Limits: | Date limit: None Language limit: None Conference abstracts: excluded |
| SYNTAX GUIDE | |
| / | At the end of a phrase, searches the phrase as a subject heading |
| .sh | At the end of a phrase, searches the phrase as a subject heading |
| * | Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings |
| adj | Requires words are adjacent to each other (in any order) |
| .ti | Title |
| .ab | Abstract |
| .hw | Heading Word; usually includes subject headings and controlled vocabulary |
| .nm | Name of Substance Word |
| .ot | Original title |
| .pt | Publication type |
| .rn | CAS registry number |
| pmez | Ovid database code; MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE Daily and Ovid MEDLINE 1946 to Present |
| oemezd | Ovid database code; Embase 1974 to present, updated daily |
| # | Searches |
|---|---|
| 1 | exp hypertension, pulmonary/ use pmez |
| 2 | pulmonary veno-occlusive disease/ use pmez |
| 3 | exp pulmonary hypertension/ use oemezd |
| 4 | ((pulmonary$ adj4 hypertens$) or (ayerza$ adj2 syndrome)).ti,ab. |
| 5 | (Lung hypertens* or lung arterial hypertens* or lung artery hypertens* or PAH or iPAH or hPAH).ti,ab. |
| 6 | ((hemangiomatosis adj3 pulmonary$) or (pulmonary$ adj2 "veno occlusive")).ti,ab. |
| 7 | 1 or 2 or 3 or 4 or 5 or 6 |
| 8 | (epoprostenol or Flolan or Caripul or Veletri or treprostinil or Remodulin or Tyvaso or bosentan or Tracleer or Usenta or ambrisentan or Volibris or Letairis or sildenafil or Viagra or Revatio or Adonix or Andros or Aphrodil or Edegra or Ejertol or Elonza or Emposil or Erectol or Erilin or Eroton or Eroxim or "Neo Up" or Patrex or Penegra or Rigix or Ripol or Sildefil or Supra or Tigerfil or Vimax or Xex or Zilden or Zwagra or tadalafil or Adcirca or Cialis or "36 Horas" or Forzest or Pasport or Xpandyl or Zydalis or macitentan or Opsumit or riociguat or Adempas).ti,ot,ab,sh,hw,nm. |
| 9 | (35121-78-9 or 81846-19-7 or 147536-97-8 or 157212-55-0 or 177036-94-1 or 139755-83-2 or 171596-29-5 or 625115-55-1 or 441798-33-0).rn,nm. |
| 10 | 8 or 9 |
| 11 | 7 and 10 |
| 12 | 11 use pmez |
| 13 | *treprostinil/ or *bosentan/ or *ambrisentan/ or *sildenafil/ or *tadalafil/ or *riociguat/ or *macitentan/ |
| 14 | (epoprostenol or Flolan or Caripul or Veletri or treprostinil or Remodulin or Tyvaso or bosentan or Tracleer or Usenta or ambrisentan or Volibris or Letairis or sildenafil or Viagra or Revatio or Adonix or Andros or Aphrodil or Edegra or Ejertol or Elonza or Emposil or Erectol or Erilin or Eroton or Eroxim or "Neo Up" or Patrex or Penegra or Rigix or Ripol or Sildefil or Supra or Tigerfil or Vimax or Xex or Zilden or Zwagra or tadalafil or Adcirca or Cialis or "36 Horas" or Forzest or Pasport or Xpandyl or Zydalis or macitentan or Opsumit or riociguat or Adempas).ti,ab. |
| 15 | 13 or 14 |
| 16 | 7 and 15 |
| 17 | 16 not conference abstract.pt. |
| 18 | 17 use oemezd |
| 19 | 12 or 18 |
| 20 | meta-analysis.pt. |
| 21 | meta-analysis/ or systematic review/ or meta-analysis as topic/ or "meta analysis (topic)"/ or "systematic review (topic)"/ or exp technology assessment, biomedical/ |
| 22 | ((systematic* adj3 (review* or overview*)) or (methodologic* adj3 (review* or overview*))).ti,ab. |
| 23 | ((quantitative adj3 (review* or overview* or synthes*)) or (research adj3 (integrati* or overview*))).ti,ab. |
| 24 | ((integrative adj3 (review* or overview*)) or (collaborative adj3 (review* or overview*)) or (pool* adj3 analy*)).ti,ab. |
| 25 | (data synthes* or data extraction* or data abstraction*).ti,ab. |
| 26 | (handsearch* or hand search*).ti,ab. |
| 27 | (mantel haenszel or peto or der simonian or dersimonian or fixed effect* or latin square*).ti,ab. |
| 28 | (met analy* or metanaly* or technology assessment* or HTA or HTAs or technology overview* or technology appraisal*).ti,ab. |
| 29 | (meta regression* or metaregression*).ti,ab. |
| 30 | (meta-analy* or metaanaly* or systematic review* or biomedical technology assessment* or bio-medical technology assessment*).mp,hw. |
| 31 | (medline or cochrane or pubmed or medlars or embase or cinahl).ti,ab,hw. |
| 32 | (cochrane or (health adj2 technology assessment) or evidence report).jw. |
| 33 | (meta-analysis or systematic review).md. |
| 34 | (comparative adj3 (efficacy or effectiveness)).ti,ab. |
| 35 | (outcomes research or relative effectiveness).ti,ab. |
| 36 | ((indirect or indirect treatment or mixed-treatment) adj comparison*).ti,ab. |
| 37 | or/20–36 |
| 38 | (Randomized Controlled Trial or Controlled Clinical Trial).pt. |
| 39 | (Clinical Trial or Clinical Trial, Phase II or Clinical Trial, Phase III or Clinical Trial, Phase IV).pt. |
| 40 | Multicenter Study.pt. |
| 41 | Randomized Controlled Trial/ |
| 42 | Randomized Controlled Trials as Topic/ |
| 43 | "Randomized Controlled Trial (topic)"/ |
| 44 | Controlled Clinical Trial/ |
| 45 | Controlled Clinical Trials as Topic/ |
| 46 | "Controlled Clinical Trial (topic)"/ |
| 47 | Clinical Trial/ or Phase 2 Clinical Trial/ or Phase 3 Clinical Trial/ or Phase 4 Clinical Trial/ |
| 48 | Clinical Trials as Topic/ or Clinical Trials, Phase II as Topic/ or Clinical Trials, Phase III as Topic/ or Clinical Trials, Phase IV as Topic/ |
| 49 | "Clinical Trial (topic)"/ or "Phase 2 Clinical Trial (topic)"/ or "Phase 3 Clinical Trial (topic)"/ or "Phase 4 Clinical Trial (topic)"/ |
| 50 | Multicenter Study/ or Multicenter Study as Topic/ or "Multicenter Study (topic)"/ |
| 51 | Randomization/ |
| 52 | Random Allocation/ |
| 53 | Double-Blind Method/ |
| 54 | Double Blind Procedure/ |
| 55 | Double-Blind Studies/ |
| 56 | Single-Blind Method/ |
| 57 | Single Blind Procedure/ |
| 58 | Single-Blind Studies/ |
| 59 | Placebos/ |
| 60 | Placebo/ |
| 61 | Control Groups/ |
| 62 | Control Group/ |
| 63 | Cross-Over Studies/ or Crossover Procedure/ |
| 64 | (random* or sham or placebo*).ti,ab,hw. |
| 65 | ((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw. |
| 66 | ((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw. |
| 67 | (control* adj3 (study or studies or trial*)).ti,ab,hw. |
| 68 | (clinical adj3 (study or studies or trial*)).ti,ab,hw. |
| 69 | (Nonrandom* or non random* or non-random* or quasi-random* or quasirandom*).ti,ab,hw. |
| 70 | (phase adj3 (study or studies or trial*)).ti,ab,hw. |
| 71 | ((crossover or cross-over) adj3 (study or studies or trial*)).ti,ab,hw. |
| 72 | ((multicent* or multi-cent*) adj3 (study or studies or trial*)).ti,ab,hw. |
| 73 | allocated.ti,ab,hw. |
| 74 | ((open label or open-label) adj5 (study or studies or trial*)).ti,ab,hw. |
| 75 | trial.ti. |
| 76 | or/38–75 |
| 77 | exp animals/ |
| 78 | exp animal experimentation/ |
| 79 | exp models animal/ |
| 80 | exp animal experiment/ |
| 81 | nonhuman/ |
| 82 | exp vertebrate/ |
| 83 | animal.po. |
| 84 | or/77–83 |
| 85 | exp humans/ |
| 86 | exp human experiment/ |
| 87 | human.po. |
| 88 | or/85–87 |
| 89 | 84 not 88 |
| 90 | 76 not 89 |
| 91 | epidemiologic methods.sh. |
| 92 | epidemiologic studies.sh. |
| 93 | cohort studies/ |
| 94 | cohort analysis/ |
| 95 | longitudinal studies/ |
| 96 | longitudinal study/ |
| 97 | prospective studies/ |
| 98 | prospective study/ |
| 99 | follow-up studies/ |
| 100 | follow up/ |
| 101 | followup studies/ |
| 102 | retrospective studies/ |
| 103 | retrospective study/ |
| 104 | case-control studies/ |
| 105 | exp case control study/ |
| 106 | cross-sectional study/ |
| 107 | observational study/ |
| 108 | quasi experimental methods/ |
| 109 | quasi experimental study/ |
| 110 | validation studies.pt. |
| 111 | (observational adj3 (study or studies or design or analysis or analyses)).ti,ab. |
| 112 | cohort*.ti,ab. |
| 113 | (prospective adj7 (study or studies or design or analysis or analyses or cohort)).ti,ab. |
| 114 | ((follow up or followup) adj7 (study or studies or design or analysis or analyses)).ti,ab. |
| 115 | ((longitudinal or longterm or (long adj term)) adj7 (study or studies or design or analysis or analyses or data or cohort)).ti,ab. |
| 116 | (retrospective adj7 (study or studies or design or analysis or analyses or cohort or data or review)).ti,ab. |
| 117 | ((case adj control) or (case adj comparison) or (case adj controlled)).ti,ab. |
| 118 | (case-referent adj3 (study or studies or design or analysis or analyses)).ti,ab. |
| 119 | (population adj3 (study or studies or analysis or analyses)).ti,ab. |
| 120 | (descriptive adj3 (study or studies or design or analysis or analyses)).ti,ab. |
| 121 | ((multidimensional or (multi adj dimensional)) adj3 (study or studies or design or analysis or analyses)).ti,ab. |
| 122 | (cross adj sectional adj7 (study or studies or design or research or analysis or analyses or survey or findings)).ti,ab. |
| 123 | ((natural adj experiment) or (natural adj experiments)).ti,ab. |
| 124 | (quasi adj (experiment or experiments or experimental)).ti,ab. |
| 125 | ((non experiment or nonexperiment or non experimental or nonexperimental) adj3 (study or studies or design or analysis or analyses)).ti,ab. |
| 126 | (prevalence adj3 (study or studies or analysis or analyses)).ti,ab. |
| 127 | or/91–126 |
| 128 | 37 or 90 or 127 |
| 129 | 19 and 128 |
| 130 | ((endothelin adj3 antagonist*) or ERA* or prostaglandin* or prostanoid* or Phosphodiesterase* Enzyme Inhibitor* or PDE5 inhibitor* or PDE 5 Inhibitor* or Phosphodiesterase Type 5 Inhibitor*).ti. |
| 131 | ((soluble guanylate cyclase or SGC) adj3 (stimulator* or activator*)).ti. |
| 132 | exp Prostaglandins/ use pmez |
| 133 | Phosphodiesterase 5 Inhibitors/ use pmez |
| 134 | exp *prostanoid/ use oemezd |
| 135 | exp *endothelin receptor antagonist/ use oemezd |
| 136 | exp *phosphodiesterase V inhibitor/ use oemezd |
| 137 | 130 or 131 or 132 or 133 or 134 or 135 or 136 |
| 138 | 7 and 137 |
| 139 | 138 and 37 |
| 140 | 129 or 139 |
| 141 | exp animals/ |
| 142 | exp animal experimentation/ or exp animal experiment/ |
| 143 | exp models animal/ |
| 144 | nonhuman/ |
| 145 | exp vertebrate/ or exp vertebrates/ |
| 146 | animal.po. |
| 147 | or/141–146 |
| 148 | exp humans/ |
| 149 | exp human experimentation/ or exp human experiment/ |
| 150 | human.po. |
| 151 | or/148–150 |
| 152 | 147 not 151 |
| 153 | 140 not 152 |
| 154 | 153 not conference abstract.pt. |
| 155 | limit 154 to english language |
| 156 | remove duplicates from 155 |
| OTHER DATABASES | |
|---|---|
| PubMed | Same MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used. |
| Trial registries (Clinicaltrials | Same keywords, limits used as per MEDLINE search. |
| Date of Search: | October, 2013 |
| Keywords: | pulmonary arterial hypertension and riociguat, macitentan, epoprostenol, treprostinil, bosentan, ambrisentan, sildenafil, and tadalafil. |
| Limits: | no date limit, English only |
Relevant websites from the following sections of the CADTH grey literature checklist, “Grey matters: a practical tool for evidence-based searching” (http://www.cadth.ca/en/resources/finding-evidence-is/grey-matters) were searched:
Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/
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