Additional Cost Comparators

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Pharmacoeconomic Review Report: tiotropium bromide monohydrate (Spiriva Respimat) for inhalation [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

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Pharmacoeconomic Review Report: tiotropium bromide monohydrate (Spiriva Respimat) for inhalation [Internet].

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APPENDIX 2Additional Cost Comparators

Table 5Costs of Additional Comparators for the Treatment of Chronic Obstructive Pulmonary Disease

Drug/Comparator	Strength	Dosage Form	Price ($)	Price/Dose ($)	Recommended Daily Use	Daily Drug Cost ($)	Average Annual Cost ($)
ICS
Budesonide (Pulmicort Turbuhaler)	100 mcg 200 mcg 400 mcg	Inhalant pwd (200 doses)	31.1600 63.7200 93.0000	0.16 0.32 0.46	200 mcg to 400 mcg twice daily	0.64 to 0.93	233 to 339
Fluticasone propionate (Flovent Diskus, Flovent)	50 mcg 100 mcg 250 mcg 500 mcg	Inhalant pwd (60 doses)	15.1300^a 23.9300^a 41.2800 82.5400	0.25 0.40 0.69 1.38	100 mcg to 500 mcg twice daily	0.80 to 2.75	291 to 1,004
Fluticasone propionate (Flovent Diskus, Flovent)	50 mcg 125 mcg 250 mcg	Aerosol MDI (120 doses)	23.9300 41.2800 82.5400	0.20 0.34 0.69	100 mcg to 500 mcg twice daily	0.80 to 2.75	291 to 1,004
Ciclesonide (Alvesco)	100 mcg 200 mcg	Solution aerosol (120 doses)	45.2160 74.7600	0.38 0.62	100 mcg to 800 mcg once daily	0.38 to 2.49	138 to 910
Short-acting muscarinic antagonist
Ipratropium Bromide (Atrovent)	20 mcg	MDI (200 doses)	18.9200	0.09	2 × 20 mcg 3 to 4 times daily	0.57 to 0.76	207 to 276
SABA
Salbutamol (Airomir)	100 mcg	Inhalant pwd (200 doses)	5.0000	0.02	100 mcg to 200 mcg up to 4 times daily	0.10 to 0.20	36 to 73
Salbutamol (Ventolin, generics)	100 mcg	Inhalant pwd (200 doses)	5.0000	0.02	100 mcg to 200 mcg up to 4 times daily	0.10 to 0.20	36 to 73
Terbutaline (Bricanyl Turbohaler)	0.5 mg	Inhalant pwd (200 doses)	15.2800	0.08	0.5 mg up to 6 times daily	0.08 to 0.46	28 to 167
Xanthine Bronchodilator
Theophylline (Uniphyl, generic)	100 mg 200 mg 300 mg 400 mg 600 mg	SR Tab SR Tab SR Tab SR Tab SR Tab	0.1300 0.1350 0.1750 0.5030 0.6090	0.13 0.14 0.18 0.50 0.61	Once daily, generally 400 mg to 800 mg (varies with patient’s lean muscle mass)	0.50 to 1.00	184 to 367

: ICS = inhaled corticosteroid; MDI = metered dose inhaler; pwd = powder; SABA = short-acting beta-2 agonist.
a: Saskatchewan Drug Plan (February 2015).
: Source: Alberta Health Formulary (February 2015), unless otherwise stated.

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Pharmacoeconomic Review Report: tiotropium bromide monohydrate (Spiriva Respimat) for inhalation [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul. APPENDIX 2, Additional Cost Comparators.
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