The objective of this report is to perform a systematic review of the beneficial and harmful effects of abobotulinumtoxinA (aboBoNTA) for the symptomatic treatment of lower-limb spasticity in pediatric patients two years of age and older.

Contents

• Abbreviations
• Executive Summary
  • Introduction
  • Results and Interpretation
  • Potential Place in Therapy
  • Conclusions
• Introduction
  • Disease Prevalence and Incidence
  • Standards of Therapy
  • Drug
• Objectives and Methods
  • Objectives
  • Methods
• Results
  • Findings From the Literature
  • Included Studies
  • Exposure to Study Treatments
  • Critical Appraisal
  • Efficacy
  • Harms
• Discussion
  • Summary of Available Evidence
  • Interpretation of Results
• Conclusions
• Appendix 1. Patient Input Summary
• Appendix 2. Literature Search Strategy
• Appendix 3. Excluded Studies
• Appendix 4. Detailed Outcome Data
• Appendix 5. Validity of Outcome Measures
• Appendix 6. Summary of Study 147 (Extension Study)
• Appendix 7. Summary of Indirect Comparisons
• References

Version: Final with Redactions

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