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OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jul.

Cover of OnabotulinumtoxinA for Injection (Botox)

OnabotulinumtoxinA for Injection (Botox): For the Prophylaxis of Headaches in Adults With Chronic Migraine (≥ 15 Days per Month With Headache Lasting 4 Hours a Day or Longer) [Internet].

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ABBREVIATIONS

AE

adverse event

ANCOVA

analysis of covariance

BSC

best supportive care

CDR

CADTH Common Drug Review

CI

confidence interval

CM

chronic migraines

DB

double-blind

EF

emotional function

EM

episodic migraine

ER

emergency room

EQ-VAS

Euro-Qol Visual Analog Scale

HC

Health Canada

HDPM

headache days per month

HIT

Headache Impact Test

HNC

Headache Network Canada

HRQoL

health-related quality of life

ICHD-2

International Classification of Headache Disorders, 2nd edition

ICHD-3

International Classification of Headache Disorders, 3rd edition

IM

intramuscularly

ITT

intention-to-treat

MCID

minimally clinically important difference

MIDAS

Migraine Disability Assessment Scale

mLOCF

modified last observation carried forward

MOH

medication-overuse headache

MSQ

Migraine-Specific Quality of Life Questionnaire

OLE

open-label extension

PGIC

physician’s global impression of change

RP

role function – preventive

RR

role function – restrictive

SAE

serious adverse event

SD

standard deviation

SGIC

subject’s global impression of change

U

unit

WDAE

withdrawal due to adverse event

Copyright © CADTH 2015.

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Please contact CADTH’s Vice-President of Corporate Services at ac.htdac@secivresetaroproc with any inquiries about this notice or other legal matters relating to CADTH’s services.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

Bookshelf ID: NBK344289

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